In the clinic of coronavirus infection (SARS-CoV-2), inflammatory symptoms of the upper respiratory tract and pulmonary parenchyma prevail, and intestinal damage and the appearance of digestive symptoms are more characteristic of long-term pathology. The aim of the study was to retrospective analyze fatal cases of intestinal lesions in a new Covid-19 infection. In total, 9 patients with fatal intestinal lesions were identified out of a total of 2,781 deaths during the three years of operation of the Nikolaevskaya Hospital hospital in St. Petersburg, which was repurposed to provide medical care to patients with the new coronavirus infection Covid-19 (SARS-Cov-2). The described pathoanatomical manifestations in the form of mesenteric vascular thrombosis and wall necrosis, corresponding to the clinical definition of «fatal intestinal lesion», are recognized as conditions incompatible with life and unavoidable at the stage of qualified and specialized therapeutic care.