Features of iron homeostasis in patients with steatohepatitis of alcoholic and non-alcoholic etiology and its correlation with the intensity of oxidative stress and apoptosis

Abstract

Topicality. Comorbid course of alcoholic steatohepatitis (ASH) and non alcoholic steatohepatitis (NASH) with dysmetabolic iron overload syndrome (DIOS) is caused by the cascade of interload reactions, which may contribute to the progression of the disease. DIOS is a pathological condition characterized by a quantitative increase in the content of elemental iron in the body, which leads to the damage of organs and tissues due to the toxic effects of excess iron. DIOS formation is associated with congenital or acquired insufficiency of mechanisms of the regulation of iron excretion, accumulation in the population of gene mutations of proteins-regulators of iron metabolism; inefficient erythropoiesis and insufficient utilization of iron in the bone marrow, with the changes in the quality of nutrition (predominant consumption of meat products); increasing life expectancy, living in geozones

Health-Related Quality of Life Assessment for Liver Cirrhosis Patients at a Tertiary Care Hospital in Karachi, Pakistan

“…In addition to the seriousness and implications of liver cirrhosis, certain symptoms specific to the disease, such as itching, muscle cramps, sleep problems, sexual dysfunction, exhaustion, and gastrointestinal symptoms, are significant in assessing the quality of life in this group of patients [8]. The prognosis for individuals with cirrhosis can be affected by several factors, including Child-Turcotte-Pugh and Model for End-Stage Liver Disease scores, non-alcoholic etiology, and the patient's body mass index [9,10].…”