Features of Microsurgical Anatomy of the Small Intestine in Experimental Widespread Purulent Peritonitis

Esipov, V. K.; Kagan, I. I.; Yashnikov, S. V.

doi:10.18499/2225-7357-2019-8-2-43-46

Cited by 1 publication

(1 citation statement)

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“…Inflammation of the abdominal cavity causes a decrease in the depth of intestinal crypts by 10%. According to the authors, the intestinal crypts are responsible for the renewal of the epithelial lining of the intestine for body balance control [25], it can be concluded that a decrease in the depth of the crypts is a morphological sign of a decrease in the regenerative activity of the epithelium of the small intestine [26]. The authors have shown that the absence of peristalsis leads to the loss of intestinal colonization resistance, translocation of pathogenic and opportunistic microflora to unusual habitats, bacteremia, the development of abdominal sepsis, and multiple organ failure [27,28].…”

Section: Resultsmentioning

confidence: 99%

Morphofunctional and morphometric features of the small intestine in experimental rats with inflammation of the abdominal cavity

Abdreshov,

Yessenova,

Yeshmukhanbet

et al. 2024

IJBCh

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The article presents studies of the effect of fecal suspension by introducing into the abdominal cavity at the rate of 0.5 ml of a 10% solution per 100 g of animal body weight. The morpho-functional state and morphometric analyzes of the small intestine were studied in normal conditions and with inflammation of the abdominal organs by introducing fecal suspension. The results showed that inflammation of the abdominal organs led to significant changes in the wall of the small intestine, multiple hemorrhages and fibrin clots were found. In the intestine, there is a change and violation of the structures of the small intestine, the total thickness of the mucous membrane increases. Violation of goblet cells, villus height and crypt depth occur. Analysis of the study showed that the walls of the small intestine, revealed structural changes, mainly in the mucosa, submucosa and muscle membranes. The mean value of the mucosal thickness in the control group was 526.17±17.11 micrometer; submucous layer – 47.21±1.63 micrometer. Phenomena of edema, inflammatory infiltration, and separation of muscle fibers were noted in both layers of the muscular membrane. The average layer of thickness of the muscular membrane was 145.67±6.92 µm. Changes in the mucous membrane of the small intestine, at one time reflected in the structural changes in the villi-crypt of the small intestine. A violation of microcirculation in the tissues of the small intestine after the inflammatory process was revealed, which leads to aggravation of dystrophic and necrobiotic lesions of the overall state of the small intestine and is combined with the severity of the clinical picture in experimental animals.

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Section: Resultsmentioning

confidence: 99%