Features of Redox Regulation in Tumor Cells

doi:10.15372/ssmj20190202

Cited by 6 publications

(3 citation statements)

References 65 publications

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“…Vitamin E supplementation stimulated tumor progression and reduced survival in in vivo experiments (mice) on lung cancer models caused by BRAF and KRAS gene expression. Antioxidants reduce the amount of reactive oxygen species and DNA damage, but they also reduce the expression of p53 (Teplova et al 2018;Zenkov et al 2019). In our opinion, the nonlinear dose-dependent therapeutic and toxic effect may be associated with a change in the pro/antioxidant status of the cell.…”

Section: Stage II Administration Of the Studied Compounds In Metronom...mentioning

confidence: 81%

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Evaluation of the pharmacological activity of hybrid organotin compounds in a B16 melanoma model in the classical and metronomic administration modes

Додохова¹,

Сафроненко²,

Котиева³

et al. 2022

RRP

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Introduction: In modern medical chemistry, much attention is paid to the search for new antimetastatic agents based on metal compounds. Organotin compounds promise to be good candidates as the treatment of malignant neoplasms. In order to reduce a possible nonspecific toxic effect of tin compounds and to expand the intended therapeutic use, the paper presents hybrid tin (IV) complexes with Sn-S bond containing a fragment of 2,6-di-tert-butylphenol. The aim of the study was to evaluate the antitumor and antimetastatic effects of bis (3,5-di-tert-butyl-4-hydroxyphenylthiolate) dimethylolol (Me3) and (3,5-di-tert-butyl-4-hydroxyphenylthiolate) triphenylolol (Me5) in a model of transplanted melanoma tumor in B16 mice in classical and metronomic administration mode. Materials and methods: The efficacy of organotin compounds was studied in a model of a transplanted tumor with spontaneous metastasis of C57Bl/6 (female) melanoma B16 mice using the following indicators: average life expectancy, inhibition of tumor growth by weight, tumor mass, and metastasis inhibition index. Results and discussion: The most pronounced antimetastatic effect (54% and 36%) is achieved with a five-fold intraperitoneal injection of Me3 and Me5 at the total doses of 375 mg/kg and 250 mg/kg. The comparable results of the efficacy were obtained in the classical and metronomic modes of the injection of hybrid organotin compounds. With an increase in the injected dose, there is an effect of activating the tumor process with the generalized metastasis. Conclusion: Bis dimethylolol (Me3) and triphenylolol (Me5) compounds demonstrate both a pronounced antimetastatic activity and a multidirectional effect on the growth of the primary focus and the metastasis in lungs, depending on an injected dose.

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Section: Stage II Administration Of the Studied Compounds In Metronom...mentioning

confidence: 81%

“…The research results by other authors can be cited as confirmation of our hypothesis. The efficacy of antioxidants from the class of spatially hindered phenols in terms of protecting the liver with toxic hepatopathy from metastasis was established in (Menshchikova et al 2019).…”

Section: Stage II Administration Of the Studied Compounds In Metronom...mentioning

confidence: 99%

Evaluation of the pharmacological activity of hybrid organotin compounds in a B16 melanoma model in the classical and metronomic administration modes

Додохова¹,

Сафроненко²,

Котиева³

et al. 2022

RRP

View full text Add to dashboard Cite

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“…As a result, more than 100 different chemical compounds are formed in the aqueous phase, some of which have significant biological activity and a significant lifetime [10]. Some of these products are called reactive oxygen species [11], whereas some are classified as reactive nitrogen species [12]. Reactive oxygen species at high concentrations can cause oxidative stress and at low concentrations have a significant stimulating effect on living systems [13].…”

Section: Introductionmentioning

confidence: 99%

Portable Technology for Obtaining Plasma-Activated Water to Stimulate the Growth of Spruce and Strawberry Plants

Danileyko,

Belov,

Egorov

et al. 2023

Horticulturae

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A method for stimulating the growth of spruce and strawberry in the early phases of development is proposed. A technology for obtaining plasma-activated water (PAW) with the help of a glow discharge plasma generator was developed. The method is proposed for increasing the shelf life of PAW by adding an aqueous colloid of polyvinylpyrralidone (PVP) polymer. It is shown that after treatment with a PAW + PVP mixture, the seeds have a higher percentage of germination, the plants develop faster in the early stages, and they are more viable. At the physicochemical level, after seed treatment with PAW + PVP, higher rates of metabolite outflow from seeds are observed. At the biological level, seed treatment with PAW + PVP leads to a slight decrease in the activity of antioxidant enzymes and a higher content of chlorophylls in the leaves, and a slightly higher assimilation rate is observed. In the leaves, there is higher content of the growth hormone indole-3-acetic acid (IAA), whereas the content of the growth-inhibiting hormone abscisic acid decreases. The use of a stimulating drug based on the composition of an aqueous solution activated by plasma and polyvinylpyrrolidone (PAW + PVP) polymer can be an effective means of a single pre-sowing treatment of spruce seeds in solving the problem of reforestation and strawberry during plant propagation.

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Molecular-genetic and cytogenetic characteristics of sporadic kidney cancer: literature review

Popov¹,

Guseynov

Skryabin³

et al. 2022

Onkourologiâ

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To compile this literature review, we studied at least 100 publications devoted to the genetic basis of clear cell, papillary, and chromophobic sporadic kidney cancer pathogenesis. Each of them considered the role of somatic gene and chromosomal mutations in the initiation, promotion, and tumor progression of sporadic renal cell carcinoma, emphasized the importance of determining the mutagenic profile of renal cell carcinoma for the future fate of patients.

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Features of Redox Regulation in Tumor Cells

Cited by 6 publications

References 65 publications

Evaluation of the pharmacological activity of hybrid organotin compounds in a B16 melanoma model in the classical and metronomic administration modes

Evaluation of the pharmacological activity of hybrid organotin compounds in a B16 melanoma model in the classical and metronomic administration modes

Portable Technology for Obtaining Plasma-Activated Water to Stimulate the Growth of Spruce and Strawberry Plants

Molecular-genetic and cytogenetic characteristics of sporadic kidney cancer: literature review

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