Features of Retinal Neurogenesis as a Key Factor of Age-Related Neurodegeneration: Myth or Reality?

Telegina, Darya V.; Kozhevnikova, Oyuna S.; Antonenko, Anna K.; Kolosova, N. G.

doi:10.3390/ijms22147373

Cited by 7 publications

(5 citation statements)

References 132 publications

(207 reference statements)

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“…Refer to panel A or table S1 for specific timing differences). Data sourced from the translating time database, as well as others: [16‒19, 26, 28, 30‒81]. A detailed list of the references that pertain to each feature, timepoint, and species can be found in online supplementary Table S1, as well as more detailed somite numbers, and developmental staging (Theiler staging for mouse, Witchi staging for rat, and McCrady staging for opossum).…”

Section: Resultsmentioning

confidence: 99%

Translating the Timing of Developmental Benchmarks in Short-Tailed Opossums (Monodelphisdomestica) to Facilitate Comparisons with Commonly Used Rodent Models

Bresee,

Litman-Cleper,

Clayton

et al. 2024

Brain Behav Evol

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Introduction: The gray short-tailed opossum, Monodelhis domestica (M. domestica) is a widely used marsupial model species that presents unique advantages for neurodevelopmental studies. Notably their extremely altricial birth allows manipulation of postnatal pups at timepoints equivalent to embryonic stages of placental mammals. A robust literature exists on the development of short-tailed opossums, but many researchers working in the more conventional model species of mice and rats may find it daunting to identify the appropriate age at which to conduct experiments. Methods: Here we present detailed staging diagrams taken from photographic observations of 40 individual pups, in 6 litters, over 25 time points across postnatal development. We also present a comparative neurodevelopmental timeline of short-tailed opossums, the house mouse (Mus musculus), and the laboratory rat (Rattus norvegicus) during embryonic as well as postnatal development, using time points taken from this study and a review of existing literature, and use this dataset to present statistical models comparing the opossum to the rat and mouse. Results: One aim of this research is to aid in testing the generalizability of results found in rodents to other mammalian brains, such as the more distantly related metatherians. However, this broad dataset also allows the identification of potential heterochronies in opossum development compared to rats and mice. In contrast to previous work, we found broad similarity between the pace of opossum neural development with that of rats and mice. We also found that development of some systems was accelerated in the opossum, such as the forelimb motor plant, oral motor control, and some aspects of the olfactory system, while the development of the cortex, some aspects of the retina, and other aspects of the olfactory system are delayed compared to the rat and mouse. Discussion: The pace of opossum development is broadly similar to that of mice and rats, which underscores the usefulness of this species as a compliment to the more commonly used rodents. Many features that differ the most between opossums and rats and mice were either clustered around the day of birth and were features that have functional importance for the pup immediately after or during birth, or were features that have reduced functional importance for the pup until later in postnatal development, given that it is initially attached to the mother.

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Section: Resultsmentioning

confidence: 99%

Translating the Timing of Developmental Benchmarks in Short-Tailed Opossums (Monodelphisdomestica) to Facilitate Comparisons with Commonly Used Rodent Models

Bresee,

Litman-Cleper,

Clayton

et al. 2024

Brain Behav Evol

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“… 40 It occurs in the context of progressive alterations in cellular metabolism, stress responses, apoptosis, and protein aggregation and continues as cellular senescence ensues. 40 , 41 The features of retinal remodeling include photoreceptor degeneration, glial responses, neural reprogramming, and widespread rewiring, and there is an increase in the activity of these pathways before the eventual cell death seen in end-stage disease. 40 We found a relative decrease in pathways associated with retinal remodeling in the N-AMD group compared with the early or intermediate NN-AMD group in our study, including those involved in neuron projections and synapses.…”

Section: Discussionmentioning

confidence: 99%

Aqueous Fluid Transcriptome Profiling Differentiates Between Non-Neovascular and Neovascular AMD

Kaidonis

Lamy

et al. 2023

Invest. Ophthalmol. Vis. Sci.

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Purpose Early and intermediate non-neovascular AMD (NN-AMD) has the potential to progress to either advanced NN-AMD with geographic atrophy, or to neovascular AMD (N-AMD) with CNV. This exploratory study performed an unbiased analysis of aqueous humor transcriptome in patients with early or intermediate NN-AMD vs. treatment-naïve N-AMD to determine the feasibility of using this method in future studies investigating pathways and triggers for conversion from one form to another. Methods Aqueous humor samples were obtained from 20 patients with early or intermediate NN-AMD and 20 patients with untreated N-AMD, graded on clinical examination and optical coherence tomography. Transcriptome profiles were generated using next-generation sequencing methods optimized for ocular samples. Top-ranked transcripts were compared between groups, and pathway enrichment analysis was performed. Results Seventy-eight differentially expressed transcripts were identified. Unsupervised clustering of differentially expressed transcripts was able to successfully differentiate between the two groups based on aqueous transcriptome alone. Pathway analysis highlighted changes in expression of genes associated with mitochondrial respiration, oxidative stress, ubiquitination, and neurogenesis between the two groups. Conclusions This pilot study compared the aqueous fluid transcriptome of patients with early or intermediate NN-AMD and untreated N-AMD. Differences in transcripts and transcriptome pathways identified in the aqueous of patients with early or intermediate NN-AMD compared with patients with N-AMD are consistent with those previously implicated in the pathogenesis of these distinct AMD subtypes. The findings from this exploratory study warrant further investigation using a larger, prospective study design, with the inclusion of a control group of eyes without AMD.

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“…They are later detected in the aorta–gonads–mesonephros (E10.5), fetal liver (E11.5) and then the bone marrow (E14–16.5), which becomes the dominant hematopoietic site in the adult state. Concurrently, retina development begins around E10 and matures postnatally [ 17 , 18 ]. Multiple studies have shown that some resident immune cells in the retina, typically microglia, are seeded in the eye from hematopoietic cells in the embryonic yolk sac, which migrate and proliferate in the retina [ 19 , 20 ].…”

Section: Introductionmentioning

confidence: 99%

Hematopoietic Cells Influence Vascular Development in the Retina

Asare-Bediako

Adu-Agyeiwaah

Abad

et al. 2022

Cells

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Hematopoietic cells play a crucial role in the adult retina in health and disease. Monocytes, macrophages, microglia and myeloid angiogenic cells (MACs) have all been implicated in retinal pathology. However, the role that hematopoietic cells play in retinal development is understudied. The temporal changes in recruitment of hematopoietic cells into the developing retina and the phenotype of the recruited cells are not well understood. In this study, we used the hematopoietic cell-specific protein Vav1 to track and investigate hematopoietic cells in the developing retina. By flow cytometry and immunohistochemistry, we show that hematopoietic cells are present in the retina as early as P0, and include microglia, monocytes and MACs. Even before the formation of retinal blood vessels, hematopoietic cells localize to the inner retina where they eventually form networks that intimately associate with the developing vasculature. Loss of Vav1 lead to a reduction in the density of medium-sized vessels and an increased inflammatory response in retinal astrocytes. When pups were subjected to oxygen-induced retinopathy, hematopoietic cells maintained a close association with the vasculature and occasionally formed ‘frameworks’ for the generation of new vessels. Our study provides further evidence for the underappreciated role of hematopoietic cells in retinal vasculogenesis and the formation of a healthy retina.

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Features of Retinal Neurogenesis as a Key Factor of Age-Related Neurodegeneration: Myth or Reality?

Cited by 7 publications

References 132 publications

Translating the Timing of Developmental Benchmarks in Short-Tailed Opossums (<i>Monodelphis</i><i>domestica</i>) to Facilitate Comparisons with Commonly Used Rodent Models

Translating the Timing of Developmental Benchmarks in Short-Tailed Opossums (<i>Monodelphis</i><i>domestica</i>) to Facilitate Comparisons with Commonly Used Rodent Models

Aqueous Fluid Transcriptome Profiling Differentiates Between Non-Neovascular and Neovascular AMD

Hematopoietic Cells Influence Vascular Development in the Retina

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