Features of Second Primary Cancer in Patients with Gastric Cancer

Abstract

Background: In order to improve the prognosis of gastric cancer patients, the timely identification of second primary cancers is considered to be a crucial clinical problem. Methods: We analyzed the clinicopathological data of 2,250 patients with gastric cancer with regard to both synchronous and metachronous second primary cancers. Results: Of 2,250 patients, 95 (4.2%) had a second primary cancer. Both colorectal and lung cancer were frequently detected, followed by cancer in the liver, esophagus and breast. Regarding the time of detection for such second cancers, 65% of colorectal cancers were detected synchronously, while more than 80% of lung cancers were detected metachronously. The prognosis of gastric cancer patients with a second primary cancer was more negatively influenced by a second primary cancer than by a primary gastric cancer. Conclusion: Since gastric cancer patients may develop synchronous and metachronous second cancers in other organs, effective preoperative and postoperative diagnostic modalities both for second primary cancers, as well as for the recurrence of gastric cancer, need to be developed.

Duodenal stump cancer after Billroth-II distal gastrectomy for gastric cancer

“…Recently, some studies have reported that the risk of metachronous cancer associated with gastric cancer is elevated with increasing age, and this would negatively infl uence the prognosis of gastric cancer patients [1][2][3]. In published reports, the incidence of metachronous cancer occurring after gastric cancer is 1.4%-4.2%, and it tends to occur more frequently in patients with EGC [1][2][3]. The colorectum is the most common site, followed by the lung and liver [1,2].…”

“…In published reports, the incidence of metachronous cancer occurring after gastric cancer is 1.4%-4.2%, and it tends to occur more frequently in patients with EGC [1][2][3]. The colorectum is the most common site, followed by the lung and liver [1,2]. However, a signifi cant correlation between metachronous duodenal cancer and gastric cancer has not yet been established, even though synchronous duodenal cancer associated with gastric cancer has been reported [11].…”

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EGC have a risk of developing a second primary (metachronous) cancer, such as colorectal, lung, or liver cancer [1][2][3].The duodenal stump after Billroth II (B-II) distal gastrectomy is a rare site for cancer recurrence unless a tumor-free margin has not been achieved. Moreover, to our knowledge, there are no previously published studies regarding the occurrence of recurrent or metachronous cancer at the duodenal stump.

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“…EGC have a risk of developing a second primary (metachronous) cancer, such as colorectal, lung, or liver cancer [1][2][3].…”

Clinicopathologic features of gastric cancer with synchronous and metachronous colorectal cancer in Korea: are microsatellite instability and p53 overexpression useful markers for predicting colorectal cancer in gastric cancer patients?

“…Previous studies have demonstrated that 3.4-5.9 % of patients with GC have a secondary primary cancer, and colorectal cancer (CRC) is the most commonly diagnosed secondary primary cancer in patients with GC [1][2][3][4]. In previous studies of synchronous CRC that was screened for using colonoscopy in GC patients, 2-5 % of patients were found to have second primary CRCs, depending on the patient's election criteria and the time of colonoscopy [5][6][7][8][9].…”