Features of the Course of Chronic Bronchitis in Patients With Concomitant Gastroesophageal Reflux Disease

Makarova, G. V.; Rekalova, E.M.

doi:10.31655/2307-3373-2019-4-37-42

Cited by 2 publications

(3 citation statements)

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“…These diseases are combined in 25 -60% of cases (Shevchuk-Budz,2018, Lin et al 2019. According to numerous studies, the presence of GERD is associated with a deterioration in the quality of life in this cohort of patients, worsening of symptoms, deterioration of external respiration, which leads to more frequent exacerbations of COPD (Makarova et al 2019, Francis,2016. Occurrence of GERD in patients with COPD can be both primary-independent diseases (due to combined lesions of the mucous membranes of the respiratory and digestive systems, associated with unidirectional metabolic and allergic changes and dysregulation of the nervous, immune and endocrine systems) and as primary-dependent pathological processes (when lung obstruction with the appearance of GERD may be exacerbated by microaspiration of gastric contents into the trachea and bronchi, as well as in the process of stimulation of nervus vagus receptors of the distal part of the esophagus.…”

Section: Introductionmentioning

confidence: 99%

The Role of Pepsinogens in the Formation of Gerd in Patients With Copd

Лях

Tovt-Korshynska

2022

SJPU

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The article presents data on the role of pepsinogen-1 and -2 and bilirubin in the formation of gastroesophageal reflux disease (GERD) in patients with chronic obstructive pulmonary disease (COPD). Clinical, biochemical, immunological research methods were used in the work. The activity of pepsinogens 1 and 2 and bilirubin in saliva was determined in all patients with combined pathology. It has been established that the presence of concomitant GERD in patients is an independent aggravating factor for the function of external respiration. In patients with concomitant GERD, a significant increase in acute phase parameters in the serum, indicating active systemic inflammation. Increased activity of the cytokine IL-6 and IFNγ indicates the activation of the cellular immune system, with an unregulated immune response that supports chronic inflammation in the bronchi even in remission. Increased levels of IL-4 are compensatory in nature, as IL-4 inhibits the production of macrophages of proinflammatory cytokines, including IL-6. Detection of correlations between the concentration of total bilirubin in saliva with a decrease in external respiration, namely FVC, FEV-1, as well as the presence of shortness of breath allows us to consider bilirubin as a possible marker of reflux and respiratory inflammation in the bronchi, until obstruction. The positive correlation of pepsinogen-1 in saliva with an allergic history, and pepsinogen-2 in saliva with cough, shortness of breath and smoking, and a negative correlation of pepsinogen-1 with the value of FEV1 / FVC, allows to consider pepsinogen-1 and pepsinogen-2 as markers of non-acid reflux and respiratory inflammation with bronchoobstruction

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Section: Introductionmentioning

confidence: 99%

The Role of Pepsinogens in the Formation of Gerd in Patients With Copd

Лях

Tovt-Korshynska

2022

SJPU

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“…Особливу актуальність має проблема ведення хворих з поєднанням гастроезофагеальної рефлюксної хвороби (ГЕРХ) та хронічного обструктивного захворювання легень (ХОЗЛ) [4,5,6]. Адже таке поєднання ускладнює діагностику та перебіг захворювань, знижує ефективність лікування та сприяє погіршенню прогнозу [7].…”

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“…Отже, оцінюючи показники функції зовнішнього дихання у хворих усіх груп виявлено достовірне зниження показників МОШ 25, 50,75. У групі з супутньою і без супутньої ГЕРХ -значне зниження, ознака обструкції на рівні дрібних і середніх бронхів, що є характерна особливість ХОЗЛ згідно даних багатьох досліджень [2,4,6,7].…”

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Clinical Characteristics of the Combined Course of Chronic Obstructive Pulmonary Disease and Gastroesophagal Reflux Disease

Лях¹,

Tovt-Korshynska²,

Derbak³

2021

Ukr. ž. med. bìol. sportu

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The comorbid diseases can occur at any stage of bronchial obstruction, and, regardless of the severity or phase of chronic obstructive pulmonary disease, significantly affect disability, increase the frequency of hospitalizations, and increase the cost of medical care. The presence of concomitant gastroesophageal reflux disease in patients with chronic obstructive pulmonary disease is an independent aggravating risk factor for exacerbations and is associated with health deterioration of this group of patients. The purpose of the study was to study the features of the clinical course of chronic obstructive pulmonary disease in combination with gastroesophageal reflux disease. Materials and methods. Retrospective analysis of 138 patients who were treated in the pulmonology department for exacerbation of the disease and outpatient treatment by a gastroenterologist was carried out. 3 groups of patients were formed: 1 group (n=60) – patients with chronic obstructive pulmonary disease in combination with gastroesophageal reflux disease, 2 group (n=42) – patients with chronic obstructive pulmonary disease without signs of gastroesophageal reflux disease, who were treated in the pulmonology department for exacerbation of the disease and 3 group (n=36) – patients with gastroesophageal reflux disease who were treated on an outpatient basis. The patients were similar in age, stage of disease and duration of illness. The average age of the patients was 55±1.64. It should be noted, regarding the gender characteristics of the groups, that among the examined patients by gender, men predominated – 78.4% (80 out of 102). Results and discussion. The main clinical and anamnestic features of the combined pathology were studied. The significance of the assessment of functional changes in spirometry indexes in this category of patients is described. A significant decrease in external respiration function was revealed in the indicators of the external respiration function in patients of all groups. In the patients with chronic obstructive pulmonary disease in combination with gastroesophageal reflux disease the frequency of exacerbations increases. These exacerbations were associated with the presence and severity of gastrointestinal symptoms, namely increased heartburn, acid regurgitation causes worsening of respiratory symptoms, until the exacerbation of the disease with subsequent hospitalization. Also the length of stay in the hospital of the patients in this group increased by 1.5±0.4 days, which is associated with a severe exacerbation of chronic obstructive pulmonary disease and the need to use a double dose of glucocorticoids to control the symptoms of respiratory failure. Among the complaints of patients with combined pathology, extraesophageal manifestations of gastroesophageal reflux disease prevailed. Conclusion. The presence of concomitant gastroesophageal reflux disease in patients with chronic obstructive pulmonary disease expands and aggravates the clinical manifestations of the underlying disease

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Features of the Course of Chronic Bronchitis in Patients With Concomitant Gastroesophageal Reflux Disease

Cited by 2 publications

References 1 publication

The Role of Pepsinogens in the Formation of Gerd in Patients With Copd

The Role of Pepsinogens in the Formation of Gerd in Patients With Copd

Clinical Characteristics of the Combined Course of Chronic Obstructive Pulmonary Disease and Gastroesophagal Reflux Disease

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