Features of the development of latent autoimmune diabetes in adults (LADA)

Timakova, A.A.; Saltykov, B B

doi:10.17116/patol20198104178

Arkh. patol.

2019

DOI: 10.17116/patol20198104178

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Features of the development of latent autoimmune diabetes in adults (LADA)

A.A. Timakova¹,

B B Saltykov²

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Cited by 2 publications

References 24 publications

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Prognosis and outcome of latent autoimmune diabetes in adults: T1DM or T2DM?

Zhou,

Xu,

Xiong

et al. 2024

Diabetol Metab Syndr

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Latent Autoimmune Diabetes in Adults (LADA) is a type of diabetes mellitus often overlooked in clinical practice for its dual resemblance to Type 1 Diabetes Mellitus (T1DM) in pathogenesis and to Type 2 Diabetes Mellitus (T2DM) in clinical presentation. To better understand LADA’s distinctiveness from T1DM and T2DM, we conducted a comprehensive review encompassing etiology, pathology, clinical features, treatment modalities, and prognostic outcomes. With this comparative lens, we propose that LADA defies simple classification as either T1DM or T2DM. The specific treatments for the disease are limited and should be based on the therapies of T1DM or T2DM that address specific clinical issues at different stages of the disease. It is crucial to identify LADA cases potentially misdiagnosed as T2DM, warranting prompt screening for poor blood sugar control, short-term blood sugar deterioration, and other conditions. If the prognosis for LADA is similar to T2DM, it can be managed as T2DM. However, if the prognosis fundamentally differs, early LADA screening is crucial to optimize patient outcomes and enhance research on tailored treatments. The pathogenesis of LADA is clear, so the prognosis may be the key to determining whether it can be classified as T2DM, which is also the direction of future research. On the one hand, this paper aims to provide suggestions for the clinical screening and treatment of LADA based on the latest progress and provide worthy directions for future research on LADA.

show abstract

Prognosis and outcome of latent autoimmune diabetes in adults: T1DM or T2DM?

Zhou,

Xu,

Xiong

et al. 2024

Diabetol Metab Syndr

View full text Add to dashboard Cite

show abstract

Type 1 diabetes mellitus: features of differential diagnosis

Gantsgorn,

Denisenko,

Osipenko

et al. 2023

BRSMU

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Type 1 diabetes mellitus is a condition caused by autoimmune damage to insulin–producing beta cells of the pancreatic islets, leading to endogenous insulin deficiency. Despite the sufficient knowledge of the disease and the availability of clinical recommendations for substitution therapy, the number of patients with this pathology is growing worldwide. At the same time, their cohort is very heterogeneous, including amid different etiology, concomitant genetic background, variations in the manifestation of the disease and severity. In this regard, traditional ideas about type 1 diabetes mellitus are being questioned, which requires special attention when managing patients with a clinical picture of the disease that differs from the traditional one. The article presents a clinical case of type 1 diabetes mellitus in a young patient, which demonstrates the importance of a personalized approach to the diagnosis and treatment of diabetic patients with a "non-classical" history.

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Features of the development of latent autoimmune diabetes in adults (LADA)

Cited by 2 publications

References 24 publications

Prognosis and outcome of latent autoimmune diabetes in adults: T1DM or T2DM?

Prognosis and outcome of latent autoimmune diabetes in adults: T1DM or T2DM?

Type 1 diabetes mellitus: features of differential diagnosis

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