Features of the Hormonal and Cardiometabolic Profile in Young Men With the Hypotalamic Syndrome of the Late Pubertary Period

Tsertsvadze, L.K.; Авдеева, М.В.; Scheglova, L.V.; Василенко, Владимир Станиславович

doi:10.17513/spno.29064

Cited by 3 publications

(1 citation statement)

References 4 publications

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“…Вместе с тем российские ученые полагают, что появление розовых стрий, прежде всего, обусловлено дисфункцией гипоталамуса и усилением продукции кортизола [26]. В более ранних исследованиях нами были продемонстрированы более выраженные гормональные, метаболические и гемодинамические нарушения у пациентов с гипоталамическим синдромом (ожирение с розовыми стриями), чем при конституционально-экзогенном ожирении [27,28], что доказывает целесообразность рассмотрения гипоталамического синдрома с позиции отдельно выделенной нейроэндокриннообменной патологии.…”

Section: обсуждение основного результата исследованияunclassified

Markers of endothelial dysfunction in adolescent and young patients with hypothalamic syndrome

et al. 2020

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Background: Endothelial dysfunction is the first but reversible stage of atherosclerosis. A change in the functional state of the vascular endothelium, especially of a growing organism, can be the basis for the development of many diseases in adulthood. The study of the structural and functional state of peripheral vessels of adolescents with hypothalamic syndrome is extremely important for understanding of the mechanisms of formation of cardiometabolic risks.Aims: to compare the structural and functional state of the vascular wall of young men with hypothalamic syndrome and constitutionally exogenous obesity.Methods: During the study 360 males were examined (average age 21.27±2.44 years) and divided into 3 groups: group 1 -with hypothalamic syndrome (n=242); group 2 - with constitutionally exogenous obesity (n=98); control group - practically healthy individuals (n=20). Hypothalamic syndrome was verified in the presence of a symptom complex, including obesity and pink striae. Cross-group comparative analysis of results of clinical, laboratory and instrumental examination was carried out.Results: In the group of patients with hypothalamic syndrome, endothelium-dependent vasodilatation (9.44±1.26 versus 10.37±1.21%; p=0.001) and endothelium-independent vasodilatation (10.29±1.28 versus 11.29±1.14%; p=0.001) is worse than in the group of patients with constitutionally exogenous obesity, and the rate of endothelium-dependent vasodilatation is lower than the generally accepted norm. In addition, among patients with hypothalamic syndrome, the stiffness of the vascular wall is higher than among patients with constitutionally exogenous obesity (15.47±2.58 versus 13.24±3.84%; p=0.001). Statistically significant correlations were revealed between the structural and functional state of peripheral arteries and hemodynamic, hormonal, metabolic changes, and the level of C-reactive protein (p<0.05).Conclusions: The obtained data indicate a deterioration of endothelial function and an increase in vascular wall stiffness in obese patients, regardless of its etiology. The patients with hypothalamic syndrome have more pronounced structural and functional changes in the vascular wall are observed than patients with constitutionally exogenous obesity.

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Section: обсуждение основного результата исследованияunclassified

Markers of endothelial dysfunction in adolescent and young patients with hypothalamic syndrome

et al. 2020

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Predictors of metabolic syndrome development in adolescent and young aged patients with hypothalamic obesity

Tsertsvadze¹,

Авдеева²,

Shcheglova³

et al. 2021

Profil. med.

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Assessing salivary innate immune responses in adolescents with dentofacial abnormalities and central precocious puberty

Kolesnik,

Belousova

2024

jour

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Relevance. Central precocious puberty (CPP), characterized by a high incidence of 60% among endocrinopathies during puberty, significantly influences dentofacial development and the local immune defense mechanisms in adolescents. However, the impact on saliva's innate immune function remains underexplored.This study aims to evaluate the innate immune function of saliva in individuals with CPP coexisting with dentofacial abnormalities.Materials and methods. An analysis of saliva biochemical markers was conducted on 59 adolescents diagnosed with CPP and dentofacial abnormalities, alongside a control group of 21 age-matched individuals with dentofacial abnormalities but without systemic conditions, aged 13-18 years. The evaluation focused on lysozyme and urease levels, dysbiosis markers indicating oral microbiota status, malondialdehyde (MDA) levels, and catalase activity to gauge the balance between pro-oxidant and antioxidant systems, alongside proteolytic enzyme elastase activity.Results. Adolescents with combined CPP and dentofacial abnormalities exhibited weakened antioxidant and antibacterial defenses, evidenced by decreased catalase activity (0.105 ± 0.020 mkat/l, p < 0.001) and lysozyme levels (54.7 ± 3.2 U/l, p < 0.02), against a backdrop of increased lipoperoxidation and microbial contamination (MDA levels at 0.48 ± 0.11 μmol/l, p < 0.05, urease levels at 0.713 ± 0.015 μkat/l, p < 0.01), and heightened inflammation (elastase activity up to 2.71 ± 0.12 μkat/l, p < 0.01).Conclusion. The diminished innate immune function in saliva necessitates the development of strategies to enhance it, serving as a preventive measure against gingivitis in patients with CPP.

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Features of the Hormonal and Cardiometabolic Profile in Young Men With the Hypotalamic Syndrome of the Late Pubertary Period

Cited by 3 publications

References 4 publications

Markers of endothelial dysfunction in adolescent and young patients with hypothalamic syndrome

Markers of endothelial dysfunction in adolescent and young patients with hypothalamic syndrome

Predictors of metabolic syndrome development in adolescent and young aged patients with hypothalamic obesity

Assessing salivary innate immune responses in adolescents with dentofacial abnormalities and central precocious puberty

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