Features of the Immune Status of Women of Reproductive Age Suffering From Genital Infectious-Inflammatory Processes

Колесникова, Н. В.; Чудилова, Г. А.; Ломтатидзе, Л В; Filippov, E. F.; Ковалева, С. В.; Krutova, V. A.; Сторожук, А. П.

doi:10.25207/1608-6228-2017-24-6-65-70

Kuban. nauсh. med. vestnik

2017

DOI: 10.25207/1608-6228-2017-24-6-65-70

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Features of the Immune Status of Women of Reproductive Age Suffering From Genital Infectious-Inflammatory Processes

Н. В. Колесникова¹,

Г. А. Чудилова²,

Л В Ломтатидзе³

et al.

Abstract: Федеральное государственное бюджетное образовательное учреждение «Кубанский государственный медицинский университет» Министерства здравоохранения Российской Федерации, ул. Седина, 4, Краснодар, Россия, 350063. АННОТАЦИЯ Цель. Комплексная оценка различных звеньев иммунитета женщин репродуктивного возраста с генитальны-ми инфекционно-воспалительными процессами.Материалы и методы. В исследовании использована периферическая кровь 30 пациенток с воспалительными заболеваниями органов малого таза (ВЗОМТ), 30 пациент… Show more

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The effectiveness of immunomodulatory therapy with a synthetic analogue of the active center of the hormone thymus thymopoietin in the complex treatment of immunocompromised women with chronic infectious and inflammatory diseases of the pelvic organs

Kovaleva,

Nesterova,

Pikturno

et al. 2023

Russian Journal of Immunology

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Chronic inflammatory diseases of the pelvic organs (pelvic inflammatory disease, PID) in women is among the main understudied problems in gynecology worldwide with adverse medical and socio-economic consequences, thus justifying the need for further study of immunopathogenesis and development of new approaches to treatment. Our objective was to develop new immunotherapeutic approaches to correction of combined disorders of the immune system functioning in immunocompromised women with PID and to evaluate their clinical and immunological efficacy. 55 women aged 20-40 years were examined, i.e., 35 patients with exacerbation of sluggish or recurrent PID, resistant to conventional therapy. Testiung was performed before complex treatment (study group 1 GI- 1) and after the course (study group 2 GI-2). Contents of T and B lymphocytes, natural killer cells (NK) (CYTOMICS FC500, USA), phagocytic and microbicidal functions of neutrophilic granulocytes (NG) were assessed in SG-1 and SG-2 before and 2-3 days after complex treatment with addition of an immunotherapeutic drug based on hexapeptide (HP) at a daily dose of 45 mg/ml intramuscularly for 10 days. In patients from SG-1, a decrease in T cells (CD3+CD19- ) and B cells (CD3-CD19+), a 2-fold increase in the content of NK CD3-CD16+CD56+ was found, along with altered functioning of NG (deficiency of actively phagocytizing NG, a decrease in their digestive function and NADPH-oxidase activity). In SG-2 patients, the treatment was followed by restoration of the T (CD3+CD19-) and B cells (CD3-CD19+), NK cells (CD3-CD16+CD56+), like as an increase in effector functions, i.e., microbial capture by NG and their killing ability due to activation of NADPH oxidases and normalization of microbicidal reserve capacity in the NG cell population. Positive clinical effect included reduction of clinical symptoms in acute period, absence of PID exacerbations over follow-up for 6 months (85.6% of cases). Occasional exacerbations of PID were associated with medical manipulations (5.7%) and unprotected sexual contacts (5.7%). The immunopathogenetically proven approach to correction of combined functional impairment of immune system in the women with PID shows a positive clinical and immunological effect.

show abstract

The effectiveness of immunomodulatory therapy with a synthetic analogue of the active center of the hormone thymus thymopoietin in the complex treatment of immunocompromised women with chronic infectious and inflammatory diseases of the pelvic organs

Kovaleva,

Nesterova,

Pikturno

et al. 2023

Russian Journal of Immunology

View full text Add to dashboard Cite

show abstract

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Features of the Immune Status of Women of Reproductive Age Suffering From Genital Infectious-Inflammatory Processes

Cited by 1 publication

References 1 publication

The effectiveness of immunomodulatory therapy with a synthetic analogue of the active center of the hormone thymus thymopoietin in the complex treatment of immunocompromised women with chronic infectious and inflammatory diseases of the pelvic organs

The effectiveness of immunomodulatory therapy with a synthetic analogue of the active center of the hormone thymus thymopoietin in the complex treatment of immunocompromised women with chronic infectious and inflammatory diseases of the pelvic organs

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