The aim of this study is to estimate the peculiarities of the bioefficacy of geomagnetic activity in the period of the COVID-19 pandemic (March–April, 2020) and reveal the specific factors of space weather that impact the sensitivity of the myocardium of healthy volunteers to geomagnetic activity in the given period. The bioefficacy of geomagnetic activity has been studied in healthy volunteers for the first time. There were persons whose initial myocardium disorder was caused by the COVID-19 pandemic. The study continued for 2 months (March–April, 2020) with the daily control of the T-wave coefficient in the electrocardiogram phase portrait, the daily
Kp
index of the geomagnetic activity, dynamical solar wind pressure,
Bz
components of the interplanetary magnetic field, and solar radiation with the wave length of 10.7 cm. Two types of responses of the cardiovascular system were revealed—immediate (typical for cardio-sensitive volunteers) and delayed (for cardio-insensitive persons). The analysis of the extended spectrum of the space-weather parameters made it possible for the first time to determine the combination and the value of geophysical features of geomagnetic activity that cause delayed response (for 1–2 days) in cardio-insensitive persons: the daily
Kp
index over 20 relative units, the dynamical solar wind pressure over 2.0 nPa, and the negative value of
Bz
components of the interplanetary magnetic field.