This paper has a purpose to explore the effects of home posture control combined with goal-activity-exercise-environment therapy on motor function in children with severe cerebral palsy (CP). Data of 80 children with severe CP treated from January 2022 to December 2023 were collected. They were divided into experimental group (EG) and control group according to different treatment methods, with 40 people in each group. The controlled group (CG) obtained routine treating means, including occupational therapy, electromyographic biofeedback therapy, and other treatment items. The EG received a combination of home posture control and goal-activity-exercise-environment therapy on the basis of conventional treatment. Meanwhile, parents received professional training to manage their children’s posture and received reinforcement training through goal-activity-exercise-environment therapy. The Gross motor function measure-88, Peabody developmental motor scale-fine motor, pediatric balance scale, Fugl–Meyer assessment and other scales were used to evaluate the motor function, balance ability, daily living activity ability, and developmental level of patients. After 3 months of treatment, the Gross motor function measure-88 scores of these 2 groups were 70.96 ± 18.29 and 57.42 ± 21.41, respectively. The Peabody developmental motor scale-fine motor scores were 76.48 ± 14.42 and 59.77 ± 14.89, respectively. The balance ability index, upper limb motor function index, daily living activity ability, and developmental level of the EG were significantly higher than the CG’s, and the P-values were all <.05. The combination of home posture control and GAME therapy can significantly improve the motor function and daily living activities of children with severe CP. This helps to maintain the normal growth and development of the child, and has certain clinical value.