FebriDx Point-of-Care Testing to Guide Antibiotic Therapy for AcuteRespiratory Tract Infection in UK Primary Care: A Retrospective OutcomeAnalysis

Davidson, Miles

doi:10.4172/2329-8731.1000165

Cited by 14 publications

(25 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Evidence for the clinical utility of FebriDx is available from a retrospective chart review analysis involving 21 patients who were administered the FebriDx test after presenting to an outpatient general practice with symptoms of an ARI [39]. The patients were all from a single practice in the UK and had a mean age of 46.3 years (range, 3-84 years).…”

Section: Clinical Utility Of Febridxmentioning

confidence: 99%

“…The patients were all from a single practice in the UK and had a mean age of 46.3 years (range, 3-84 years). The analysis involved a chart review (for each patient) of the suspected clinical diagnosis, the FebriDx test result, antibiotic prescriptions (including possible management alterations), and the response to therapy and patient outcome [39].…”

Section: Clinical Utility Of Febridxmentioning

confidence: 99%

“…Based on the analysis, the FebriDx test altered the clinical management in 10 (48%) of the 21 cases [39]. These included eight cases where antibiotics were withheld when the FebriDx test indicated a viral infection (six cases) or a negative result (two cases) after a clinical diagnosis of a possible bacterial infection, and two cases where antibiotics were prescribed when the FebriDx test indicated a bacterial infection after a clinical diagnosis of a probable viral infection; one of these two patients was subsequently diagnosed with bacterial sepsis and hospitalized.…”

Section: Clinical Utility Of Febridxmentioning

confidence: 99%

“…These included eight cases where antibiotics were withheld when the FebriDx test indicated a viral infection (six cases) or a negative result (two cases) after a clinical diagnosis of a possible bacterial infection, and two cases where antibiotics were prescribed when the FebriDx test indicated a bacterial infection after a clinical diagnosis of a probable viral infection; one of these two patients was subsequently diagnosed with bacterial sepsis and hospitalized. Additionally, there were two higher-risk patients (a 3-year-old patient with sudden physical deterioration and a 60-year-old immunocompromised patient) who were prescribed antibiotics despite a negative FebriDx test result [39].…”

Section: Clinical Utility Of Febridxmentioning

confidence: 99%

“…All patients in the analysis achieved a full clinical recovery [39]. Excluding the patient who was diagnosed with bacterial sepsis after testing positive for bacterial infection by FebriDx, no patient experienced any clinical complications or required any further unscheduled medical consultations [39].…”

Section: Clinical Utility Of Febridxmentioning

confidence: 99%

See 4 more Smart Citations

FebriDx®: A Rapid Diagnostic Test for Differentiating Bacterial and Viral Aetiologies in Acute Respiratory Infections

Shirley

2019

Mol Diagn Ther

View full text Add to dashboard Cite

FebriDx ® is a rapid, point-of-care diagnostic test that is designed to aid in the differentiation of bacterial and viral acute respiratory infections (ARIs), thus helping to guide decisions regarding the prescription of antibiotics in the outpatient setting. FebriDx carries a CE mark for use in the EU and is also approved in several other countries, including Canada, Saudi Arabia and Singapore. It is indicated for use in patients > 2 years old with symptoms consistent with a community-acquired ARI. The test involves the use of an immunoassay on a fingerstick blood sample to provide simultaneous, qualitative measurement of elevated levels of C-reactive protein (CRP) and myxovirus resistance protein A (MxA). In two prospective, multicentre studies in patients with acute upper respiratory tract infections, FebriDx was shown to be both sensitive and specific in identifying patients with a clinically significant infection and in differentiating between infections of bacterial and viral aetiology. The test is simple, requires no additional equipment and produces actionable results in ~ 10 min. As was demonstrated in a small, retrospective analysis, FebriDx results can help guide (improve) antibiotic prescribing decisions. Reducing the unnecessary or inappropriate prescription of antibiotics for ARIs of probable viral aetiology is important for antibiotic stewardship and can also reduce the unnecessary exposure of patients to the risk of antibiotic-related adverse events. FebriDx thus represents a useful diagnostic tool in the outpatient setting. FebriDx®: a summaryA simple, all-in-one, diagnostic test to assist in the diagnosis of bacterial or viral ARIs by measuring the host response to infection Based on a rapid immunoassay that provides simultaneous, qualitative measurement of elevated levels of CRP and MxA Sensitive and specific in identifying patients with a clinically significant infection and in differentiating between infections of bacterial and viral aetiology Produces actionable results in ~ 10 min which can be used to help guide antibiotic prescribing decisions turer of FebriDx was also offered an opportunity to review this article. Changes resulting from comments received were made on the basis of scientific and editorial merit.

show abstract

Section: Clinical Utility Of Febridxmentioning

confidence: 99%

Section: Clinical Utility Of Febridxmentioning

confidence: 99%

Section: Clinical Utility Of Febridxmentioning

confidence: 99%

Section: Clinical Utility Of Febridxmentioning

confidence: 99%

Section: Clinical Utility Of Febridxmentioning

confidence: 99%

See 3 more Smart Citations