Febrile convulsions: A clinical study with special reference to heredity and prognosis

Livingston, Samuel; Bridge, Edward M.; Kajdi, Laslo

doi:10.1016/s0022-3476(47)80139-8

Cited by 40 publications

(10 citation statements)

References 7 publications

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“…The incidence of FC in siblings of probands of both sexes with positive past histories was 13.3%, which was markedly lower than the incidence of 24.4% in siblings of probands with a negative past history. This finding seems to support the theory proposed by Livingston et al (8) that in the absence of a family history of FC, exogenous damage to the brain may be the cause of FC.…”

Section: Study O F the Multifactorial Inheritance Theorysupporting

confidence: 90%

A Genetic Study of Febrile Convulsions

Fukuyama

Kagawa

Tanaka³

1979

Eur Neurol

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307 probands with febrile convulsions classed as the simple type (131 children) and the complicated type (176 children) were genetically analyzed. There was a tendency toward familial aggregation of febrile convulsions, and genetic involvement was suggested. The multifactorial mode of inheritance best agreed with the observations. (1) The ratio of incidence of febrile convulsions in siblings of probands in the present study (19.9%) to the incidence in the general population (2.9%), i.e., 6.85, was rather close to the expected ratio of 5.87 from the multifactorial inheritance system. (2) The incidence in siblings tended to be higher when either or both of their parents had a history of febrile convulsions. In 2-child families where the first child was affected, the incidence in the second child tended to increase in parallel with the increasing incidence in parents. (3) The incidence in siblings was higher if probands were males. (4) The heritability, when estimated by Falconer’s procedure, was as high as 76%, showing that febrile convulsions are strongly genetically predisposed. These findings were more distinctly observed in the simple type than in the complicated type.

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Section: Study O F the Multifactorial Inheritance Theorysupporting

confidence: 90%

A Genetic Study of Febrile Convulsions

Fukuyama

Kagawa

Tanaka³

1979

Eur Neurol

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“…There is general agreement that the risk for spontaneous fits is greater for children who have convulsed when feverish than for the general population (Faerber, 1929;Herlitz, 1941;Livingston et al, 1947;Debre et al, 1948;Zellweger, 1948;Lennox, 1949Lennox, , 1953Ekholm and Niemineva, 1950;Friderichsen and Melchior, 1954;Melin, 1954;Cary, 1956;Hrbek, 1957;Laplane et al, 1958;Bamberger and Matthes, 1959;Horstmann and Schinnerling, 1963;Doose et al, 1966;Degen and Goller, 1967;Millichap, 1968; Van den Berg and Yerushalmy, 1969;Frantzen et al, 1970).…”

Section: Discussionmentioning

confidence: 99%

Spontaneous fits after convulsions with fever.

Wallace¹

1977

Archives of Disease in Childhood

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SUMMARY 112 of an original sample of 134 children with febrile convulsions were reviewed between 8 years and 9 years 10 months after their initial attack. 17 % of those followed up had had at least one spontaneous fit. A significant correlation was found with perinatal abnormalities. 12 % had continuing recurrent fits. Persisting grand mal occurred most commonly in lower social class children who had had perinatal abnormalities and continued to have long-term neurological disorders. Psychomotor epilepsy correlated significantly with a prolonged or repeated initial convulsion with unilateral features. It is suggested that the development of grand mal and temporal lobe epilepsies after convulsions with fever are determined by different mechanisms.

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“…In 1947 Livingstone et al pointed out that many previous authors had included in their analyses all types of childhood convulsions and reported the results of a special study of children "whose first convulsion was associated with an acute febrile illness. "7 Lennox defined a febrile convulsion as severe if it or the following coma lasted an hour or more or if it started in, or included chiefly, one arm or leg or one side of the body.'…”

Section: Definitionsmentioning

confidence: 99%

Febrile convulsions in a national cohort followed up from birth. II--Medical history and intellectual ability at 5 years of age.

Verity¹,

Butler²,

Golding³

1985

BMJ

138

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Three hundred and three children with febrile convulsions were identified in a national birth cohort of 13 135 children followed up from birth to the age of 5 years. Breech delivery (p <0 05) was the only significantly associated prenatal or perinatal factor. There were no associations with socioeconomic factors.Excluding the 13 known to be neurologically abnormal before their first febrile convulsion, children who had had a febrile convulsion did not differ at age 5 from their peers who had not had febrile convulsions in their behaviour, height, head circumference, or performance in simple intellectual tests. IntroductionAlthough febrile convulsions are relatively common, considerable confusion remains about whether the seizures in themselves have a deleterious effect on the subsequent development of the child. Theoretically, at least, a convulsion can result in cerebral anoxia with the death of brain cells and consequent loss of intellectual and motor ability.In 1942 Thom published the results of a community based study of children who had had "infantile convulsions."' He reported that 120o of these children were mentally defective (Intelligence Quotient (IQ) <75) and a further 13°o retarded (IQ 75-90), concluding that "infantile convulsions do tend to increase materially the risk of epilepsy and mental deficiency in later life." The study may be criticised: the children were part of a selected group; their neurological state before the convulsions was not taken into account and the infantile convulsions were of mixed aetiology and type. These criticisms apply to many subsequent follow up studies of children who have had febrile

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Febrile convulsions: A clinical study with special reference to heredity and prognosis

Cited by 40 publications

References 7 publications

A Genetic Study of Febrile Convulsions

A Genetic Study of Febrile Convulsions

Spontaneous fits after convulsions with fever.

Febrile convulsions in a national cohort followed up from birth. II--Medical history and intellectual ability at 5 years of age.

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