Febrile convulsions affect ultrasonic vocalizations in the rat pup

Keller, Avril J.; Saucier, Deborah M.; Sheerin, Aaron H.; Yager, Jerome Y.

doi:10.1016/j.yebeh.2004.06.005

Cited by 13 publications

(8 citation statements)

References 25 publications

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“…Of interest, they also found decreased USV latency after seizures only in male rats. Similar sex‐specific effects were found in a separate study where investigators induced febrile seizures on PD7 and reported an increase in USVs in male rats on PD12 . The authors of this study used a Petterson model D100 Ultrasound Detector and set the frequency range to 20–30 kHz.…”

Section: Discussionsupporting

confidence: 68%

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The effect of early life status epilepticus on ultrasonic vocalizations in mice

et al. 2016

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Summary Objective Infant crying is a series of innate vocal patterns intended to elicit the attention of adult caregivers for fulfillment of specific needs, such as pain, hunger, or hypostimulation. It is one of the earliest forms of observable communication. In neonatal rodents, this behavior has recently been investigated as a potential early behavioral marker of neural deficits in neurodevelopmental disorders. However, few studies have examined the effects of seizures on vocalization behavior during the neonatal period. The purpose of this study is to investigate the effect of a single kainate-induced early life seizure on vocalization behavior in mice. This study also investigates the subsequent effect of seizures on two pathways critical for early neural development and epileptogenesis: the PI3K-Akt-mTOR and Canonical Wnt intracellular signaling pathways. Methods On postnatal day 10, male and female 129SvEvTac mice received a single intraperitoneal injection of kainic acid (2.5 mg/kg) or vehicle injection. The kainate administration resulted in 1–2 hours of status epilepticus. On postnatal days 11 and 12, the quantity and duration of isolation-induced ultrasonic vocalizations were recorded. Western blotting analyses were performed using male and female pups on postnatal day 12. Results There was significant, male-specific suppression in the quantity and total duration of 50-kHz calls on postnatal day 12 following seizures. The hippocampi of males on this postnatal day also revealed male specific changes in the PI3K-Akt-mTOR intracellular signaling pathway, as well as changes in phosphorylated fragile × mental retardation protein. Significance These findings demonstrate that early life seizures can disrupt communication behavior in neonatal mice.

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Section: Discussionsupporting

confidence: 68%

“…Previous studies have shown abnormal ultrasonic vocalizations (USVs) in mouse models of neurodevelopmental syndromes such as fragile X syndrome, Rett syndrome, and Down syndrome . Although significant progress has been made in understanding USVs, very few studies have investigated the impact of early life seizures on this behavior …”

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confidence: 99%

The effect of early life status epilepticus on ultrasonic vocalizations in mice

et al. 2016

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“…It is unlikely that this difference is attributable to kainate versus pilocarpine-induced SE, as both compounds are known to produce seizures of equivalent severity [18]. The previous and present studies from our lab, as well as the Lopez-Meraz et al [16] study, are contrasted by another study that found PD12 male pups display a greater number of USVs following febrile convulsions on PD7 [19]. The conflicting findings between this study and previous studies may be attributable to differences in seizure-induction method or PD time chosen.…”

Section: Discussionmentioning

confidence: 61%

Early-life status epilepticus acutely impacts select quantitative and qualitative features of neonatal vocalization behavior: Spectrographic and temporal characterizations in C57BL/6 mice

Reynolds

Nolan

Huebschman

et al. 2017

Epilepsy & Behavior

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Early-life seizures are known to cause long-term deficits in social behavior, learning, and memory, however little is known regarding their acute impact. Ultrasonic vocalization (USV) recordings have been developed as a tool for investigating early communicative deficits in mice. Previous investigation from our lab found that postnatal day (PD) 10 seizures cause male-specific suppression of 50-kHz USVs on PD12 in 129 SvEvTac mouse pups. The present study extends these findings by spectrographic characterization of USVs following neonatal seizures. On PD10, male C57BL/6 pups were administered intraperitoneal injections of kainic acid or physiological saline. On PD12, isolation-induced recordings were captured using a broad-spectrum ultrasonic microphone. Status epilepticus significantly suppressed USV quantity (p=0.001) and total duration (p<0.05). Seizure pups also utilized fewer complex calls than controls (p<0.05). There were no changes in call latency or inter-call intervals. Spectrographic analysis revealed increased peak amplitude for complex, downward, short, two-syllable, and upward calls, as well as reduced mean duration for short and two-syllable calls in seizure mice. This investigation provides the first known spectrographic characterization of USVs following early-life seizures. These findings also enhance evidence for USVs as an indicator of select communicative impairment.

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“…Previous studies in both mouse and rat models have reinforced the relationship between seizures and communication deficits. A single instance of status epilepticus (SE) can affect qualitative and quantitative aspects of neonatal ultrasonic vocalization (USV) behavior [15][16][17][18]. Our lab has reported male-specific suppression in the quantity and total duration of 50 kHz calls on postnatal day 12 in 129SvEvTac mice following exposure to kainic-acid (KA) induced SE on postnatal day 10 [16].…”

Section: Introductionmentioning

confidence: 99%

High seizure load during sensitive periods of development leads to broad shifts in ultrasonic vocalization behavior in neonatal male and female C57BL/6J mice

Nolan

Hodges

Condon

et al. 2019

Epilepsy & Behavior

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There is increasing evidence that seizures during early development can impact ultrasonic vocalizations emitted from neonatal mice. However, most of the effects of early-life seizures have been reported using chemoconvulsants that produce continuous seizures (status epilepticus). In the present study, we evaluated the impact of different seizure frequency loads during early-life vocalization development in C57BL6/J male and female mice. For the high seizure load (HSL) paradigm, we administered 3 flurothyl-induced seizures to mice on PD7 through PD11, and recorded USVs on PD12. We found that the induction of seizures across PD7-11 resulted in increased average duration (P < 0.05) and cumulative duration (P < 0.05) of USVs across both sexes. Call-type analyses indicated several call-type changes, including reduced production of complex call-types from males HSL condition. For the low seizure load (LSL) paradigm, we induced 3 flurothyl seizures only on PD10 and recorded USVs on PD12. We found no change in any spectral or temporal features of USVs. However, call-type production analyses indicated that both male and female animals from the LSL paradigm also produced changes in call-types. This study provides evidence that the magnitude of communication impairment following seizures is significantly impacted by seizure frequency load early in development.

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Febrile convulsions affect ultrasonic vocalizations in the rat pup

Cited by 13 publications

References 25 publications

The effect of early life status epilepticus on ultrasonic vocalizations in mice

The effect of early life status epilepticus on ultrasonic vocalizations in mice

Early-life status epilepticus acutely impacts select quantitative and qualitative features of neonatal vocalization behavior: Spectrographic and temporal characterizations in C57BL/6 mice

High seizure load during sensitive periods of development leads to broad shifts in ultrasonic vocalization behavior in neonatal male and female C57BL/6J mice

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