Febrile seizures

Kimia, Amir A.; Bachur, Richard G.; Torres, Alcy; Harper, Marvin B.

doi:10.1097/mop.0000000000000220

Cited by 25 publications

(27 citation statements)

References 66 publications

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“…Approximately, our patients were presented with complex febrile seizures, which is similar to some studies (9,10,26), but less than the reported rate of one third of all febrile seizures in other large studies (1,8). No specific viral infection was identified in these patients and all children in whom PCR assay for viruses or bacteria was positive had been presented with simple febrile seizures.…”

Section: Discussionsupporting

confidence: 84%

“…A total of 2% -5% of children have experienced at least one febrile seizure before they reach the age of 5 (1,7,8).…”

Section: Introductionmentioning

confidence: 99%

“…The pathophysiology of FS is still unclear; it is likely that it is an age-related response of the immature brain to fever in children with a genetic predisposition, with a multi-factorial mode of inheritance, a high concordance rate in monozygotic twins, and a higher prevalence in firstand second-degree relatives (5,(8)(9)(10)(11). Studies in Iran have shown a significant geographical variance in the prevalence of febrile seizures in different parts of the country (2).…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of Viral (HHV6, Adenovirus, HSV1, Enterovirus) and Bacterial Infection in Children with Febrile Convulsion by Serum PCR and Blood Culture Mofid Children’s Hospital , 2016 - 2017

Karimi

Sakhavi

Nahanmoghaddam

et al. 2018

Arch Pediatr Infect Dis

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Background: Febrile seizures (FS) are common in young children. Viral infections that result in high fever are frequent etiologic agents that lead to febrile seizures. Human Herpesvirus 6 (HHV6), Influenza virus, adenovirus, and enterovirus have been named as the most common viruses causing high fevers in young children. Although bacterial infections have rarely been found as causative agents, many children with febrile seizures are treated with empiric antibiotics. Objectives: To determine the epidemiology of the viral (HHV6, Adenovirus, HSV1, Enterovirus) and bacterial infection in children presenting with febrile seizures. Methods: In a descriptive study, data was collected from 93 children, 3 months to 5 years of age, hospitalized with febrile seizures between September 2016 and April 2017. Relevant information was documented on a previously designed questionnaire. Blood samples were collected for culture, Serum 16S rRNA for bacteria, and PCR assay for 4 viruses (HHV6, adenovirus, enterovirus and HSV), in addition to routine investigations. Results: Of the 93 patients, serum PCR results were negative for 73 patients (78.49%) and 15 (16.13%) were positive for viruses (11 for HHV6 and 4 for Adenovirus). Serum 16S rRNA for bacteria was detected in 5 cases and blood culture was positive in 4 cases. Conclusions: Findings of this study indicate a significant prevalence of viruses and a very low rate of bacterial infection in children with febrile seizures, thus, negating the use of empirical antibiotic therapy.

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Section: Discussionsupporting

confidence: 84%

“…A total of 2% -5% of children have experienced at least one febrile seizure before they reach the age of 5 (1,7,8).…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Evaluation of Viral (HHV6, Adenovirus, HSV1, Enterovirus) and Bacterial Infection in Children with Febrile Convulsion by Serum PCR and Blood Culture Mofid Children’s Hospital , 2016 - 2017

Karimi

Sakhavi

Nahanmoghaddam

et al. 2018

Arch Pediatr Infect Dis

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“…Классическим примером того, что эпилептический приступ не обязательно означает эпилепсию, являются фебрильные судороги. После приступа фебрильных судорог у значительного числа детей могут отмечаться эпилептиформные изменения на ЭЭГ, но это, как правило, не имеет прогностического значения и не свидетельствует о способности мозга продуцировать спонтанные приступы [5].…”

Section: Abstract: Misdiagnosis Of Epilepsy Children Non Epilepticunclassified

Causes of overdiagnosis of epilepsy in children

Belousova

2019

Ross. vestn. perinatol. pediatr.

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Misdiagnosis of epilepsy is a common phenomenon (up to 20% of the total population of patients with epilepsy and up to 30–40% in the population of pharmacoresistant epilepsy) and dangerous, leads to significant social restrictions and is accompanied by significant unjustified medical expenses. The objective reasons for misdiagnosis include a large number (about 40) of conditions that are similar and often indistinguishable in their clinical manifestations from epileptic seizures, descriptive character and lack of obligatory diagnostic criteries (especially electroencephalographic), limiting medical access to the necessary research methods. The subjective errors include insufficiently collecting anamnesis, exaggerating the possibility of developing a more rare disease (in this case epilepsy), a false impression of the doctor that if epilepsy is not diagnosed, then it will have the most terrible consequences. The situation of misdiagnosis is aggravated by the fact that neurophysiologists are more likely to overestimate the EEG in the direction of epileptic and epileptiform (interictal) phenomena. Subjective errors are eliminated by learning and self-learning. Even the most experienced epileptologists can make mistakes with the diagnosis, and in a certain sense mistakes are inevitable. We can’t always wait for the final diagnosis and often have to start treatment without being 100% sure of the diagnosis of epilepsy. Therefore, it is necessary to practice the periodic revision of the diagnosis of epilepsy, especially in cases where the disease is difficult to treat.

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“…Таким образом, откладывание срока вакцинации до более старшего возраста ребенка не снижает риск развития ФС, т.е. нецелесообразно [10,11].…”

unclassified

Vaccination, febrile seizures and epilepsy

Belousova

2018

Z. nevrol. psikhiatr. im. S.S. Korsakova

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Вакцинация детей, несомненно, является эффективным методом предотвращения многих заболеваний. Но как только болезни, профилактируемые вакцинацией, стали редкими сразу возник вопрос о ее побочных эффектах. Наряду с острыми аллергическими реакциями родителей волнует возможность неврологических осложнений, например фебрильных судорог (ФС) и эпилепсии [1]. Не только многие родители, но и врачи боятся усугубления неврологических проблем в результате вакцинации, а развитие эпилепсии, совпадающее с ней по времени, только увеличивает эти опасения. В результате родители либо откладывают сроки вакцинации своих детей, либо вообще от нее отказываются, что приводит к вспышкам таких серьезных заболеваний, как корь. Конечно, невролог не должен решать вопросы: проводить или не проводить вакцинацию, чем конкретно вакцинировать ребенка. Согласно Приказу Минздрава России №125н от 21.03.14 (ред. от 13.04.17) «Об утверждении национального календаря профилактических прививок и календаря про

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Febrile seizures

Cited by 25 publications

References 66 publications

Evaluation of Viral (HHV6, Adenovirus, HSV1, Enterovirus) and Bacterial Infection in Children with Febrile Convulsion by Serum PCR and Blood Culture Mofid Children’s Hospital , 2016 - 2017

Evaluation of Viral (HHV6, Adenovirus, HSV1, Enterovirus) and Bacterial Infection in Children with Febrile Convulsion by Serum PCR and Blood Culture Mofid Children’s Hospital , 2016 - 2017

Causes of overdiagnosis of epilepsy in children

Vaccination, febrile seizures and epilepsy

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