2002
DOI: 10.1073/pnas.172398999
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Febrile temperatures induce cytoadherence of ring-stage Plasmodium falciparum -infected erythrocytes

Abstract: In falciparum malaria, the malaria parasite induces changes at the infected red blood cell surface that lead to adherence to vascular endothelium and other red blood cells. As a result, the more mature stages of Plasmodium falciparum are sequestered in the microvasculature and cause vital organ dysfunction, whereas the ring stages circulate in the blood stream. Malaria is characterized by fever. We have studied the effect of febrile temperatures on the cytoadherence in vitro of P. falciparum-infected erythrocy… Show more

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Cited by 93 publications
(91 citation statements)
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“…The release of the proinflammatory cytokine tumor necrosis factor (TNF) is believed to be responsible for the appearance of fever in malaria patients (3), and fever is known to augment the pathogenesis of malaria (4). There are a number of reports in the literature addressing the influence of elevated temperature encountered during malarial fever on the host (5) as well as the parasite (6,7).…”
mentioning
confidence: 99%
“…The release of the proinflammatory cytokine tumor necrosis factor (TNF) is believed to be responsible for the appearance of fever in malaria patients (3), and fever is known to augment the pathogenesis of malaria (4). There are a number of reports in the literature addressing the influence of elevated temperature encountered during malarial fever on the host (5) as well as the parasite (6,7).…”
mentioning
confidence: 99%
“…This was not due to any major difference in the type of malaria infection, as there was no significant difference between the two groups in parasite densities, haematocrit or temperature at the time of blood sampling (see Table I). The difference was not due to a difference in parasite stage distribution, because peripheral (venous) blood parasites in natural P. falciparum infections are nearly synchronous ring forms, as trophozoites and schizonts are selectively sequestered in the deep blood vessels, a process mediated by capillary endothelial adhesion (Udomsangpetch et al, 2002).…”
Section: Function Of Pfg6pdmentioning
confidence: 99%
“…Owing to the deep vascular schizogony in natural P. falciparum infections (Nagel & Fleming, 1992;Udomsangpetch et al, 2002), these data concern ring-form parasites only. Figure 3 shows PfG6PD mRNA (expression) as a ratio of the rRNA.…”
Section: Parasites From Natural Malaria Infectionsmentioning
confidence: 99%
“…Pattern recognition receptors, including CD36, have been implicated in innate clearance of maturestage PEs (MPEs) by monocytes and macrophages (3,12,13,15,21,22,24,26). Ring-stage PEs (RPEs) have recently been shown to express ligands capable of interacting with endothelial cells (5,16,23,29). The objective of this study was to examine whether RPEs might also interact with effector cells of the innate immune system.…”
mentioning
confidence: 99%
“…Phagocytosis of RPEs was reduced by ϳ90% in CD36-null macrophages. To investigate whether other macrophage receptors might cooperate with CD36 or mediate uptake in the absence of CD36 (1,6,14,18,19,28,29), we performed phagocytosis assays with wild-type and CD36-null macrophages in the presence of MAbs to other macrophage surface receptors. MAb blockade of receptors other than CD36 did not significantly decrease uptake of RPEs ( Fig.…”
mentioning
confidence: 99%