Febrile ulceronecrotic Mucha-Habermann disease: A case report and a review of the literature

Aytekin, Sema; Balci, Gokcen; Duzgun, Ozgur Yagdiran

doi:10.5070/d36kp6f1j2

Cited by 17 publications

(3 citation statements)

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“…Furthermore, since sepsis is thought to be associated with death [ 13 , 14 ], we analyzed the association between infection and outcome but found that neither positive blood nor skin cultures for bacteria were associated with the end of death. Our subsequent treatment study revealed that anti-infective therapy was ineffective in most FUMHD cases, which indirectly confirmed this conclusion.…”

Section: Discussionmentioning

confidence: 99%

Febrile Ulceronecrotic Mucha-Habermann Disease: A Case Report and a Systematic Review

et al. 2022

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The characteristics and treatments of febrile ulceronecrotic Mucha-Habermann disease (FUMHD) are not well-understood. We reported a FUMHD case, and searched Medline, Embase, Pubmed, Scopus, and Web of Science from inception to June 16, 2021, to perform a systematic review to synthesize its characteristics and treatments. Seventy-eight reports, including 84 people were eligible. Most of them were male (62/83, 74.7%), with high fever state (50/80, 62.5% had a high fever of 39°C or above), and with more positive skin bacterial cultures (31/41, 75.6%). Adults were associated with a higher risk of death (OR = 12.976, 95% CI: 1.049, 160.504, p = 0.046), but not positive blood bacterial cultures (p = 0.102). Systematic corticosteroids combination with other immunosuppressants (methotrexate or cyclosporine) were associated with significantly more effective cases (26/31 = 83.9%, χ2 = 4.065, p = 0.044). Furthermore, no significant differences between the low-dose and high-dose systematic corticosteroid groups were detected in treatment validation (p > 0.05). Overall, FUMHD was associated with male patients, high fever, and positive skin bacterial cultures. Early combination therapy with lower doses of corticosteroids and methotrexate or cyclosporine may be an optimal choice for the treatment of FUMHD.

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Section: Discussionmentioning

confidence: 99%

Febrile Ulceronecrotic Mucha-Habermann Disease: A Case Report and a Systematic Review

et al. 2022

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“…A comparison between adult and paediatric cases shows a more favourable outcome in children (24). In fact, fatal cases were confined to persons older than 40 years, until 2004-05 when Cozzio et al (28) and Aytekin et al (30) reported cases of 26-27-year-old females with fatal outcome.…”

Section: Case Reportmentioning

confidence: 99%

“…In the cases with fatal outcome death was attributed to pulmonary thromboembolism (8,34), pneumonia (12), cardiac arrest (15), sepsis (18,28,30,34), hypovolemic shock (27) and massive thrombosis of the superior mesenteric artery (34).…”

Section: Case Reportmentioning

confidence: 99%

Febrile Ulceronecrotic Mucha-Habermann Disease: A Case Report and Review of the Literature

Sotiriou¹,

Patsatsi²,

Tsorova³

et al. 2008

Acta Derm Venereol

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Febrile ulceronecrotic Mucha-Habermann disease is a severe variant of pityriasis lichenoides et varioliformis acuta characterized by the sudden onset of ulceronecrotic skin lesions and associated with high fever and systemic symptoms. We report here a case of a 20-year-old woman in whom the disease started as pityriasis lichenoides et varioliformis acuta and evolved to febrile ulceronecrotic Mucha-Habermann disease. Almost 90% of the body surface was involved, together with high fever and malaise. Steroids alone proved to be an insufficient therapeutic procedure. The remission achieved was attributed to the use of methotrexate. To our knowledge, only 39 cases of febrile ulceronecrotic Mucha-Habermann disease have been reported in the literature to date.

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On the Trail of a New Killer

Guitart¹,

Wood²

2009

Arch Dermatol

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Febrile ulceronecrotic Mucha-Habermann disease: A case report and a review of the literature

Cited by 17 publications

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Febrile Ulceronecrotic Mucha-Habermann Disease: A Case Report and a Systematic Review

Febrile Ulceronecrotic Mucha-Habermann Disease: A Case Report and a Systematic Review

Febrile Ulceronecrotic Mucha-Habermann Disease: A Case Report and Review of the Literature

On the Trail of a New Killer

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