Fecal Akkermansia muciniphila Is Associated with Body Composition and Microbiota Diversity in Overweight and Obese Women with Breast Cancer Participating in a Presurgical Weight Loss Trial

Frugé, Andrew D.; Pol, William Van Der; Rogers, Laura Q.; Morrow, Casey D.; Tsuruta, Yuko; Demark‐Wahnefried, Wendy

doi:10.1016/j.jand.2018.08.164

Cited by 67 publications

(48 citation statements)

References 71 publications

(76 reference statements)

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“…The majority of propionate production is associated with Bacteroidetes, Lachnospiraceae, and Negativicutes species, as well as to Roseburia inulinivorans and Ruminococcus obeum. In line with this, the abundance of Akkermansia muciniphila, a propionate-producing bacterium, is associated with the richness of the gut microbiome [61]. SCFAs have both positive and negative effects on breast cancer.…”

Section: Bacterial Metabolites In Carcinogenesismentioning

confidence: 67%

The Microbiome as a Component of the Tumor Microenvironment

Kovàcs

Mikó

Ujlaki

et al. 2020

Advances in Experimental Medicine and Biology

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Section: Bacterial Metabolites In Carcinogenesismentioning

confidence: 67%

The Microbiome as a Component of the Tumor Microenvironment

Kovàcs

Mikó

Ujlaki

et al. 2020

Advances in Experimental Medicine and Biology

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“…SCFAs can positively or negatively affect BC (74). The abundance of Akkermansia muciniphila, as a key player of propionate production, is associated with the richness of the gut microbiota in patients with BC (44).…”

Section: Host-gut Microbiome Interactionmentioning

confidence: 99%

Microbiome and Breast Cancer: New Role for an Ancient Population

et al. 2020

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There are many risk factors associated with breast cancer (BC) such as the familial history of BC, using hormone replacement therapy, obesity, personal habits, and other clinical factors; however, not all BC cases are attributed to these risk factors. Recent researches show a correlation between patient microbiome and BC suggested as a new risk factor. The present review article aimed at evaluating the role of the microbiome as a risk factor in the occurrence of BC, investigating the proposed mechanisms of interaction between the microbiome and human genes involved in BC, and assessing the impact of the altered composition of breast, gut, and milk microbiome in the physiological status of normal breast as well as cancerous or non-cancerous breast lesions. The study also evaluated the growing evidence that these altered populations may hinder chemotherapeutic treatment. The role of microbiome in the development and maintenance of inflammation, estrogen metabolism, and epigenetic alterations was properly investigated. Finally, clinical and therapeutic applications of the microbiome-e.g., probiotics, microbiome genome modulation, and engineered microbiome enzymes in the management of BC were reviewed.

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“…However, local concentrations can be as high as 1 mM [137]. SCFAs primarily bind to the free fatty acid receptors (FFARs) found on both cancer cells and stromal cells [120,121,138,139]. SCFAs can be utilized as an energy source by cells [108] and SCFAs can modulate epigenetics through inhibiting histone deacetylases [140][141][142].…”

Section: Short Chain Fatty Acids (Sfca)mentioning

confidence: 99%

Oncobiosis and Microbial Metabolite Signaling in Pancreatic Adenocarcinoma

Kiss

Mikó

Sebő³

et al. 2020

Cancers

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Pancreatic adenocarcinoma is one of the most lethal cancers in both men and women, with a median five-year survival of around 5%. Therefore, pancreatic adenocarcinoma represents an unmet medical need. Neoplastic diseases, such as pancreatic adenocarcinoma, often are associated with microbiome dysbiosis, termed oncobiosis. In pancreatic adenocarcinoma, the oral, duodenal, ductal, and fecal microbiome become dysbiotic. Furthermore, the pancreas frequently becomes colonized (by Helicobacter pylori and Malassezia, among others). The oncobiomes from long- and short-term survivors of pancreatic adenocarcinoma are different and transplantation of the microbiome from long-term survivors into animal models of pancreatic adenocarcinoma prolongs survival. The oncobiome in pancreatic adenocarcinoma modulates the inflammatory processes that drive carcinogenesis. In this review, we point out that bacterial metabolites (short chain fatty acids, secondary bile acids, polyamines, indole-derivatives, etc.) also have a role in the microbiome-driven pathogenesis of pancreatic adenocarcinoma. Finally, we show that bacterial metabolism and the bacterial metabolome is largely dysregulated in pancreatic adenocarcinoma. The pathogenic role of additional metabolites and metabolic pathways will be identified in the near future, widening the scope of this therapeutically and diagnostically exploitable pathogenic pathway in pancreatic adenocarcinoma.

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Fecal Akkermansia muciniphila Is Associated with Body Composition and Microbiota Diversity in Overweight and Obese Women with Breast Cancer Participating in a Presurgical Weight Loss Trial

Cited by 67 publications

References 71 publications

The Microbiome as a Component of the Tumor Microenvironment

The Microbiome as a Component of the Tumor Microenvironment

Microbiome and Breast Cancer: New Role for an Ancient Population

Oncobiosis and Microbial Metabolite Signaling in Pancreatic Adenocarcinoma

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