Fecal Assays Detect Hypersensitivity to Cow's Milk Protein and Gluten in Adults With Irritable Bowel Syndrome

Carroccio, Antonio; Brusca, Ignazio; Mansueto, Pasquale; Soresi, Maurizio; D’Alcamo, Alberto; Ambrosiano, Giuseppe; Pepe, Ilenia; Iacono, Giuseppe; Lospalluti, M; Chiusa, Stella Maria La; Fede, Gaetana Di

doi:10.1016/j.cgh.2011.07.030

Cited by 66 publications

(60 citation statements)

References 36 publications

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“…The current study illustrated the fact that the prevalence of IBS was many folds higher among the individual that have the problem of food hypersensitivity. Similar outcomes were reported in a study conducted by Carroccio et al (2011). Contrary to this, our result showed no significant statistical difference between the prevalence of obesity and the source of food.…”

Section: Discussioncontrasting

confidence: 57%

A study of impact and prevalence of irritable bowel syndrome among medical students

Al-Ghamdi¹,

AlOsamey²,

AlHamdan³

et al. 2015

Int. J. Med. Med. Sci.

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Irritable bowel syndrome (IBS) is considered as a prevalent gastrointestinal disorder which ischaracterized by some non-specific symptoms, such as altered bowel habits and abdominal pain. There is no recognized organic pathology associated with IBS. The prevalence of IBS is different in different communities. Its etiology remains uncertain or obscure, perhaps multifactorial. The predestined objective was the determination of prevalence, associated factors and impact of IBS on medical student studying in Prince Sattam bin Abdulaziz University. A cross-sectional study was carried out among male medical students enrolled in Prince Sattam bin Abdulaziz University during the academic year 2013 to 2014. All male medical students of second to sixth year were invited for participation in the study by filling study questionnaire. A validated, reliable, confidential, and self-administered questionnaire was used for data collection. Rome III Criteria was used for the diagnosis of irritable bowed syndrome. The IBS prevalence was 21% with profiles characterized by constipation (20.0%), diarrhea (34.3%), and other alternating symptoms (45.7%). Students who having history of chronic health problems were about three times more prone to develop IBS (OR=2.93). Those reported having stress was at 2.63 times more risk to develop IBS. Those having food hypersensitivity as compared to others were more liable to develop IBS (OR=3.29). IBS was not significantly associated with academic performance. IBS prevailed among medical students. Thus, screening of these students for psychological problems, IBS and stress management strategies are recommended for these students.

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Section: Discussioncontrasting

confidence: 57%

A study of impact and prevalence of irritable bowel syndrome among medical students

Al-Ghamdi¹,

AlOsamey²,

AlHamdan³

et al. 2015

Int. J. Med. Med. Sci.

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“…Many other studies highlighted the association between food intolerance and symptoms of IBS [8,26,27]. It was reported from a previous Turkish case-control research that the skin prick tests positivity was more common, and the mean IgE values were higher among IBS cases compared to the controls [26]. …”

Section: Discussionmentioning

confidence: 96%

Irritable bowel syndrome among paramedical students, King Abdulaziz University, Jeddah, Saudi Arabia

Ibrahim¹,

Al-Jamhoor²,

Ashour³

et al. 2018

Gastroenterol Hepatol Endosc

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Aim: The study was done to determine the prevalence and associated factors of IBS among paramedical students at King Abdulaziz University, Jeddah, Saudi Arabia. Methods:A cross-sectional study was done during 2016/2017 at the Faculty of Health Sciences, King Abdulaziz University, Jeddah. A multistage stratified random sample method was used to select 525 paramedical students. A standardized self-administered data collection sheet was used and contained the validated scales of Rome III Criteria, Hospital Anxiety and Depression Scale (HADS) and Pittsburgh Sleep Quality Index (PSQI).Results: One-third of the paramedical students met the Rome-III criteria of IBS. Nursing and dentistry students had higher IBS prevalence compared to others. IBS-Mixed and IBS-Constipation were the commonest sub-types. IBS was associated with female gender, educational specialty, family history of IBS, family income, chronic medical conditions, food hypersensitivity, traveler's diarrhea, poor sleep quality, stress, anxiety, and depression. Regression analysis revealed that female gender (aOR: 1.83; 95% CI: 1.12-3.28), stress, depression, IBS family history and poor sleeping were IBS predictors after controlling of confounding factors. Conclusion:The prevalence of IBS was high among paramedical students, and it was predicted by gender, stress, depression, poor sleeping, and family history. Screening for IBS and psychological problems, stress management courses and IBS educational programs are recommended for paramedical students.

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“…However, our data supported the evidence that mucosal infl ammation infl uenced anal resting pressure and underlined a possible role of lymphocytes and eosinophil cells. It is interesting to recall that the fecal excretion of eosinophil cationic protein has recently been suggested as a possible marker of food allergy in patients with irritable bowel syndrome-like symptoms ( 18 ), and some experimental data suggest a role for eotaxin -an eosinophil-derived cytokine -in gastrointestinal dismotility ( 28 ).…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, patients were assigned randomly, and with a double-blind method, to one of the two dietary treatment groups: Group A was treated with a " sham diet " based on the elimination of rice, potato, lamb, bean, and peas; Group B received a " true-elimination diet " based on the elimination of cow ' s milk and its derivatives, wheat, egg, tomato, and chocolate. Th ese elimination diets were arbitrarily chosen on the basis of our previous experience ( 14,18,19 ), as the foods eliminated in Group A were almost always tolerated, whereas the foods eliminated in Group B were those that most frequently caused symptoms in subjects with chronic constipation due to FH. Th e patients kept a dietary diary, and adherence to the elimination diet was evaluated by trained dieticians.…”

Section: Methodsmentioning

confidence: 99%

Oligo-Antigenic Diet in the Treatment of Chronic Anal Fissures. Evidence for a Relationship Between Food Hypersensitivity and Anal Fissures

Carroccio

Mansueto

Morfino

et al. 2013

American Journal of Gastroenterology

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OBJECTIVES:Patients with chronic constipation due to food hypersensitivity (FH) had an elevated anal sphincter resting pressure. No studies have investigated a possible role of FH in anal fi ssures (AFs). We aimed to evaluate (1) the effectiveness of diet in curing AFs and to evaluate (2) the clinical effects of a double-blind placebo-controlled (DBPC) challenge, using cow ' s milk protein or wheat. METHODS:One hundred and sixty-one patients with AFs were randomized to receive a " true-elimination diet " or a " sham-elimination diet " for 8 weeks; both groups also received topical nifedipine and lidocaine. Sixty patients who were cured with the " true-elimination diet " underwent DBPC challenge in which cow ' s milk and wheat were used. RESULTS:At the end of the study, 69 % of the " true-diet group " and 45 % of the " sham-diet group " showed complete healing of AFs ( P < 0.0002). Thirteen of the 60 patients had AF recurrence during the 2-week cow ' s milk DBPC challenge and 7 patients had AF recurrence on wheat challenge. At the end of the challenge, anal sphincter resting pressure signifi cantly increased in the patients who showed AF reappearance ( P < 0.0001), compared with the baseline values. The patients who reacted to the challenges had a signifi cantly higher number of eosinophils in the lamina propria and intraepithelial lymphocytes than those who did not react to the challenges.CONCLUSIONS: An oligo-antigenic diet combined with medical treatment improved the rate of chronic AF healing. In more than 20 % of the patients receiving medical and dietary treatment, AFs recurred on DBPC food challenge .

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Fecal Assays Detect Hypersensitivity to Cow's Milk Protein and Gluten in Adults With Irritable Bowel Syndrome

Cited by 66 publications

References 36 publications

A study of impact and prevalence of irritable bowel syndrome among medical students

A study of impact and prevalence of irritable bowel syndrome among medical students

Irritable bowel syndrome among paramedical students, King Abdulaziz University, Jeddah, Saudi Arabia

Oligo-Antigenic Diet in the Treatment of Chronic Anal Fissures. Evidence for a Relationship Between Food Hypersensitivity and Anal Fissures

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