Fecal Calprotectin: Diagnostic Accuracy of the Immunochromatographic CalFast Assay in a Pediatric Population

Radillo, Oriano; Pascolo, Lorella; Martelossi, Stefano; Bo, Sara Dal; Ventura, Alessandro

doi:10.1002/jcla.21886

Cited by 5 publications

(8 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…On-site tests for FC measurement (12)(13)(14)(15)(16)(17) have further been developed to home tests that use smartphone cameras and Internet connections, namely the IBDoc 1 and the CalproSmart. The benefit of home testing is that the FC result may be available to both the patient and physician within 2 hours of stool sampling.…”

Section: Discussionmentioning

confidence: 99%

“…As commercially available enzyme-linked immunosorbent assay (ELISA) tests that measure FC are time-consuming, new innovations have been developed for FC testing on-site (12)(13)(14)(15)(16)(17) or at home, namely the IBDoc 1 Home Test (Bu ¨hlman Laboratories AG, Scho ¨nenbuch/Basel, Switzerland) and the CalproSmart (Calpro As, Lysaker, Norway). These tests utilize smartphone applications to interconnect with a test-specific Internet portal to produce an immediate result.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Fecal Calprotectin Test Performed at Home

Piekkala

Alfthan

Merras‐Salmio

et al. 2018

J. pediatr. gastroenterol. nutr.

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Fecal Calprotectin Test Performed at Home

Piekkala

Alfthan

Merras‐Salmio

et al. 2018

J. pediatr. gastroenterol. nutr.

View full text Add to dashboard Cite

show abstract

“…Automated ELISA tests are currently available allowing to analyze the samples at any time, even individually. Importantly, the diagnostic accuracy of these tests is equivalent to the traditional ELISA method 33–40 . Recently, point of care rapid tests and home tests have been developed.…”

Section: Resultsmentioning

confidence: 99%

“…Importantly, the diagnostic accuracy of these tests is equivalent to the traditional ELISA method. [33][34][35][36][37][38][39][40] Recently, point of care rapid tests and home tests have been developed. POC tests use specific lateral flow immunoassays.…”

Section: Statementmentioning

confidence: 99%

International consensus on methodological issues in standardization of fecal calprotectin measurement in inflammatory bowel diseases

et al. 2021

View full text Add to dashboard Cite

Background: Fecal calprotectin (FC) is a non-invasive marker of gut inflammation which is frequently used to guide therapeutic decisions in patients with inflammatory bowel diseases (IBD). Each step of FC measurement can influence the results, leading to misinterpretations and potentially impacting the management of IBD patients. To date, there is high heterogeneity between FC measurements and no current method is universally accepted as a standard.Aims: Our aim was to provide clear position statementsabout the pre-analytical and the analytical phases of FC measurement to homogenize FC levels and to minimize variability and risk of misinterpretation through aninternational consensus.Materials & Methods: Fourteen physicians with expertise in the field of IBD and FC from 11 countries attended a virtual international consensus meeting on July 17th, 2020. A systematic literature was conducted and the literature evidence was shared and discussedamong the participants. Statements were formulated, discussed, and voted. Statements were considered approved if all participants agreed.Results: Nine statements were formulated and approved. Based on the available evidence, quantitative tests should be preferred for measuring FC. Furthermore, FC measurement, if possible, should always be performed with the same method and factors influencing FC levels should be taken into account when interpreting the results.Discussion: FC has an increasingly important role in the management of patients with IBD. However, large multicenter studies should be conducted to define the reproducibility and to confirm the diagnostic accuracy of the available FC tests.This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

show abstract

“…The lowest detection limit of the kit is 6.25 ng/mL. The reported sensitivity and specificity of the PhiCal test in the pediatric population were 93.2% and 86.6%, respectively29.…”

Section: Methodsmentioning

confidence: 93%

Trends of fecal calprotectin levels and associations with early life experience in preterm infants

Zhang

Zhao

et al. 2022

Interdisciplinary Nursing Research

View full text Add to dashboard Cite

Background: Preterm infants are at risk for severe infections due to their immature immune systems. Factors such as early life pain/stress experiences and feeding may influence immune activation and maturation of immune systems. However, the underlying mechanism remains unclear. Fecal calprotectin (FCP) is a noninvasive surrogate biomarker of mucosal inflammation in the gastrointestinal tract and has been used in detecting intestinal inflammation in specific pediatric gastrointestinal disorders. Objective: To describe the longitudinal trajectory of FCP levels in preterm infants and investigate the contributing factors that are associated with FCP levels. Design: A longitudinal study design was used. Settings: Preterm infants were recruited from 2 neonatal intensive care units (NICU) of a children’s medical center in the North-eastern US. Methods: Preterm infants were followed during their first 4 weeks of NICU hospitalization. Stool samples were collected twice per week to quantify the FCP levels. Cumulative pain/stress experiences and feeding types were measured daily. A linear mixed-effect model was used to examine the associations between FCP levels and demographic and clinical characteristics, cumulative pain/stress, and feeding over time. Results: Forty-nine preterm infants were included in the study. Infants’ FCP levels varied largely with a mean of 268.7±261.3 µg/g and increased over time. Preterm infants experienced an average of 7.5±5.0 acute painful procedures and 15.3±20.8 hours of chronic painful procedures per day during their NICU stay. The mean percentage of mother’s own milk increased from the first week (57.1±36.5%) to the fourth week (60.7±38.9%) after birth. Elevated FCP concentration was associated with acute and cumulative (chronic) pain/stress levels, mother’s own milk, non-White race, and higher severity of illness score. Conclusions: FCP levels were elevated in preterm infants with wide interindividual and intraindividual variations. Cumulative pain/stress during the NICU hospitalization, feeding, race, and health status may influence FCP concentrations in early life that may be associated with inflammatory gut processes.

show abstract

Fecal Calprotectin: Diagnostic Accuracy of the Immunochromatographic CalFast Assay in a Pediatric Population

Cited by 5 publications

References 28 publications

Fecal Calprotectin Test Performed at Home

Fecal Calprotectin Test Performed at Home

International consensus on methodological issues in standardization of fecal calprotectin measurement in inflammatory bowel diseases

Trends of fecal calprotectin levels and associations with early life experience in preterm infants

Contact Info

Product

Resources

About