Fecal calprotectin in children with familial Mediterranean fever in the attack‐free period

Demirbaş, Fatma; Çaltepe, Gönül; Comba, Atakan; Abbasguliyev, Hasan; Uyar, Neval Yurttan; Kalaycı, Ayhan Gazi

doi:10.1111/ped.13995

Cited by 6 publications

(3 citation statements)

References 31 publications

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“…High level of FMF may be due to chronic inflammation in FMF patients. Another study by Fatma et al concluded that FC is noninvasive simple method for assessing inflammation in childern with FMF patients [22]. The Study limitations were a relatively low number of patients and that it was crosssectional.…”

Section: Resultsmentioning

confidence: 95%

Fecal Calprotectin in assessing Familial Mediterranean Fever Patients

Mahros,

El Shenawy,

Hussien Ahmed

2023

Afro-Egyptian Journal of Infectious and Endemic Diseases

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Background and study aims: Familial Mediterranean fever (FMF) is an autoinflammatory disease presented by inflammatory attacks. Calprotectin (FC) is a calcium-binding protein that is found mainly in neutrophils, in monocytes and reactive macrophages. It considered a cytokine released from monocytes and neutrophils as a result of tissue trauma and inflammation. This study aimed to investigate fecal calprotectin levels in FMF patients as predictor of disease activity. Patients/Material andMethods: This is a Prospective cross-sectional study. Between May 2020 and May 2022, 158 patients diagnosed with FMF in our outpatient clinic in Kafrelsheikh university hospital after confirmation by PCR and obtaining Medical consent for participation in this study. Blood was collected from a peripheral vein to complete blood picture, ESR, CRP, Amyloid A, Faecal calprotectin. Blood tests were examined by ELISA; the study protocol was approved by the local ethics committee. Results: We enrolled 158 patients among them 102 patients were females, and 56 were males. Largest number of patients was diagnosed at age of twenties. Attacks last in 116 patients for less than 48 hours, while lasting for more than that in 42 patients. 130 patients had heterozygous mutation(Group 1), 28 patients had homozygous mutations(Group 2) confirmed by PCR . There was a statistically significant difference between the two groups in Fecal calprotectin level at time of diagnosis (P < 0.001616). The level Calprotectin at time of diagnosis of 100 pg/mL had 96.40% sensitivity and 96.60% Specificity. Homozygous mutation had positive correlation with Colchicine dose needed to give response. Calprotectin level have negative correlation with Colchicine dose needed. Conclusion:Our finding suggests that fecal calprotectin can be used to assess the diagnosis and severity of FMF patients. However, future studies are recommended .

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Section: Resultsmentioning

confidence: 95%

Fecal Calprotectin in assessing Familial Mediterranean Fever Patients

Mahros,

El Shenawy,

Hussien Ahmed

2023

Afro-Egyptian Journal of Infectious and Endemic Diseases

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“…The literature supports this data. Not only IBDs are associated with high fecal calprotectin levels, but also other NI fevers such as the familial Mediterranean fever show a similar trend [51]. Finally, the autoimmunity assay was reserved for patients in whom there was a high clinical suspicion of autoimmune disease; ANA and anti-cardiolipin positivity was correlated to NI fever.…”

Section: Discussionmentioning

confidence: 99%

Retrospective Analysis of Fever in Pediatric Age: Our Experience over the Last 5 Years

Valenzise,

D’Amico,

La Barbera

et al. 2024

Children

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Background: Fever is one of the most frequent symptoms highlighted during medical assistance. Due to this great impact, our study has the purpose of analyzing the demographic and laboratory characteristics of patients hospitalized in our center and identifying predictive markers to make the differential diagnosis between infectious and non-infectious fever. Methods: Our population included 220 children, collected from January 2017 to August 2022, hospitalized for continuous fever (4 days or more in duration with at least one temperature peak ≥37.5 °C) and excluded cases of discharge against medical advice and/or transfer to other operating units. Demographic (mean age at the time of admission, frequency of hospitalization, and mean days of hospitalization), laboratory, and instrumental variables were analyzed in order to find correlation with fever etiology. Results: Older age at the time of hospitalization, family history of periodic fever, fever lasting more than 8 days, and longer hospitalization are strongly associated with non-infectious fever, together with anemia, high platelet count, high CRP and ferritin, and hyponatremia at the time of admission. Paracetamol is the preferred antipyretic treatment. Echocardiogram has shown anomalies in patients with infectious fever, while ECG anomalies were detected in non-infectious fever. Conclusions: Our data underline the importance of predictive markers, such as clinical and laboratory parameters, to differentiate infectious from non-infectious fevers, but further studies are necessary.

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“…Demirbas et al evaluated faecal calprotectin in children with FMF during the non-attack period and also reported that faecal calprotectin was higher in FMF patients than in healthy children. 18 However, plasma calprotectin in patients with attacks has not yet been studied. We believe that our findings have taken steps forward by evaluating FMF patients during both attack and attack-free periods.…”

Section: Discussionmentioning

confidence: 99%

Assessment of Serum Resistin and Plasma Calprotectin Levels as Biomarkers of Inflammation in Patients with Familial Mediterranean Fever Disease

Kılıçaslan

Düzenli²,

Celi̇k³

et al. 2022

MJR

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Objective: While several inflammatory markers are known to increase in familial Mediterranean fever (FMF) disease cases, the need remains for diagnostic tests specific for FMF that monitor inflammatory activity. We aimed to investigate resistin and calprotectin levels during both attack and attack-free periods of FMF disease and evaluate their use as novel biomarkers of inflammation in patients with FMF. Materials and Methods: This cross-sectional study included 68 male patients diagnosed with FMF and 20 healthy individuals as controls. Blood samples were obtained from the patients in attack-free periods (at least 15 days after the last attack) and attack periods (in the first 24 hours). Serum resistin and plasma calprotectin levels was measured by ELISA method. Results: Resistin and calprotectin levels were significantly higher in patients during both attack (p =0.001, p <0.001) and attack-free periods (p =0.017, p =0.01) compared to the control group. Logistic regression analysis indicated that resistin levels were predictive for the diagnosis of FMF disease (OR: 1.21; 95% CI: 1.04–1.42; p =0.016). Resistin and calprotectin levels significantly correlated with C-reactive protein, erythrocyte sedimentation rate, fibrinogen, and white blood cells (0.301≤ r ≤ 0.505, p <0.05). Conclusion: Resistin and calprotectin levels were significantly higher in patients than controls, and resistin was predictive for monitoring inflammatory activity in patients with FMF.

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Fecal calprotectin in children with familial Mediterranean fever in the attack‐free period

Cited by 6 publications

References 31 publications

Fecal Calprotectin in assessing Familial Mediterranean Fever Patients

Fecal Calprotectin in assessing Familial Mediterranean Fever Patients

Retrospective Analysis of Fever in Pediatric Age: Our Experience over the Last 5 Years

Assessment of Serum Resistin and Plasma Calprotectin Levels as Biomarkers of Inflammation in Patients with Familial Mediterranean Fever Disease

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