Cirrhosis leads to sarcopenia and functional decline that can severely impact one’s ability to function at home and in society. Self-reported disability scales to quantify disability – Activities of Daily Living (ADL) and Instrumental ADL (IADL) – are validated to predict mortality in older adults. To evaluate disability in liver transplant (LT) candidates and quantify its impact on outcomes, consecutive outpatients ≥18y listed for LT with laboratory Model for End-stage Liver Disease (MELD) score ≥12 at a single high-volume U.S. LT center were assessed for ADLs and IADLs during clinic visits. Multivariable competing risk models explored the effect of disabilities on waitlist mortality (death or delisting for illness). Of 458 patients: 36% were women, median (IQR) age was 60y (54–64), initial MELD-Na was 16 (13–20). At first visit, 31% had lost ≥1 ADL, 40% ≥1 IADL. The most prevalent ADLs lost were continence (22%), dressing (12%), and transferring (11%); the most prevalent IADLs lost were shopping (28%), food preparation (23%) and medication management (22%). After adjustment for age, MELD-Na, and encephalopathy, dressing (SHR 1.7, 95%CI 1.0–2.8, p=0.04), toileting (SHR 1.9, 95%CI 1.1–3.5, p=0.03), transferring (SHR 1.9, 95%CI 1.1–3.0, p=0.009), housekeeping (SHR 1.8, 95%CI 1.2–3.0, p=0.009), and laundry (SHR 2.2, 95%CI 1.3–3.5, p=0.002), remained independent predictors of waitlist mortality.
Conclusion
ADL/IADL deficits are common in LT candidates. LT candidates would benefit from chronic disease management programs developed to address the impact of cirrhosis on their daily lives.