Fecal Metabolomics and Network Pharmacology Reveal the Correlations between Constipation and Depression

Liu, Xiaojie; Liu, Huanle; Wei, Fuxiao; Zhao, Di; Wang, Yeze; Lv, Meng; Zhao, Sheng; Qin, Xuemei

doi:10.1021/acs.jproteome.1c00435

Cited by 17 publications

(6 citation statements)

References 38 publications

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“…44 A recent study revealed that the association between the two symptoms may be due to fecal metabolite pathways and common gene functional pathways. 46 Hence, physicians and psychologists can collaborate to provide appropriate pharmacological and psychological treatment for patients affected by depression or constipation. Alternatively, from the perspective of traditional Chinese medicine, qi (energy) stagnation syndrome shares commonalities with depression in Western medicine.…”

Section: Discussionmentioning

confidence: 99%

The connections of physical and psychosocial symptoms among patients with terminal illnesses: A network analysis

Jiao

Chow

2022

Palliat Med

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Background: Patients with terminal illnesses have different symptoms. The goal of palliative care is to alleviate the suffering induced by these symptoms. Available research on symptoms has focused on their prevalence or identification of clusters. Little is known about the central symptoms contributing to the maintenance of the whole system of symptoms or the mechanism of influence between symptoms, particularly between physical and psychosocial symptoms. Aim: The study used network analysis to explore symptom clusters among patients with terminal illnesses and identify the central symptoms, the bridge symptoms, and pathways between physical and psychosocial symptoms. Design and Setting/Participants: This is a retrospective cohort study using baseline symptom assessment of 677 adults with terminal illnesses receiving care from the Integrated Community End-of-Life Care Support Teams. Results: Three symptom clusters were identified: physical, psychological, and practical clusters. “Weakness or lack of energy” was identified as the crucial symptom affecting the changes of other symptoms, followed by depression and anxiety. Three connections between the psychological and physical symptoms were identified: anxiety-pain, depression-constipation, and perceived family anxiety-poor appetite pathways. Pathways of practical concern-peace and practical concern-depression were indicated between practical and psychological symptoms. Conclusions: This study is the first of its kind to investigate the connections and mechanism of influence between symptoms among patients with terminal illnesses. It offers clear pathways for intervention with the most influential symptoms of weakness, anxiety, and depression.

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Section: Discussionmentioning

confidence: 99%

The connections of physical and psychosocial symptoms among patients with terminal illnesses: A network analysis

Jiao

Chow

2022

Palliat Med

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“…Next, excessive sleep duration always means decreased physical activity, an essential factor associated with a reduced risk of constipation ( 33 , 34 ). In addition, the indirect evidence from a meta-analysis indicates that excessive sleep time is significantly associated with increased depression risk, and depressed condition and functional constipation often co-occur and coexist in the clinic ( 35 , 36 ). Fourthly, the differential result among men and women reveals that abnormal sleep duration may also affect an intermediate factor, estrogen level, to impact further bowel movement, confirmed in animal experiments ( 37 ).…”

Section: Discussionmentioning

confidence: 99%

Association of sleep duration with chronic constipation among adult men and women: Findings from the National Health and Nutrition Examination Survey (2005–2010)

Yang

Guo

et al. 2022

Front. Neurol.

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BackgroundPrevious studies suggested that unhealthy sleep patterns were closely associated with gastrointestinal diseases, but the impact of unhealthy sleep duration on chronic constipation has not been well studied until now. In this study, we aim to explore the association between sleep duration and constipation among males and females.MethodsWe utilized the US National Health and Nutrition Examination Surveys data from 2005 to 2010, and adults (≥20 years old) who completed the sleep and bowel health questionnaires were enrolled in this observational study. Sleep duration was categorized into four groups: very short sleep (<5 h/night), short sleep (5–6 h/night), normal sleep (7–8 h/night), and long sleep (≥9 h/night). Chronic constipation was defined as Bristol Stool Scale Type 1(separate hard lumps, like nuts) or Type 2(sausage-like but lumpy). Controlling demographic, lifestyle, and dietary factors, the logistic regression model in Generalized Linear Model (GLM) function was used to estimate the correlation of sleep duration with constipation among men and women.ResultsOf the 11,785 individuals (51.2% males and 48.8% females), 4.3% of men and 10.2% of women had constipation, respectively. More than half of patients with constipation did not adopt the recommended sleep duration. Compared with normal individuals, male participants with constipation had a higher proportion of shorter sleep duration (41.0 vs. 32.3% in the short sleep group and 6.3 vs. 4.7% in the very short sleep group), and female individuals with constipation had a higher proportion of long sleep duration (12.7 vs. 8.2%). After covariates adjustment, men with short sleep duration (5–6 h/night) correlated with increased odds for constipation (OR:1.54, 95%CI:1.05–2.25), and women with long sleep duration (≥9 h/night) linked to the higher constipation risk (OR:1.58, 95%CI:1.10–2.29). Excessive sleep duration in males or insufficient sleep duration in females was neither linked to increased nor decreased constipation risk.ConclusionsIn this observational study of a nationally representative sample of adults, we demonstrate a differential impact of unhealthy sleep duration on constipation among men and women. Short sleep duration poses a higher risk of constipation in men, and excessive sleep duration correlates with higher constipation risk in women.

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“…The faecal water content, gastric emptying rate, gastrointestinal ink push rate, and gastrointestinal hormones of gastrin (GAS) and motilin (MTL) were applied to characterise the gastrointestinal functions of rats. On top of this, each index was standardised, and then was applied to assess the associations among indexes related to depression and constipation, as previously described 16 …”

Section: Methodsmentioning

confidence: 99%

“…On top of this, each index was standardised, and then was applied to assess the associations among indexes related to depression and constipation, as previously described. 16 Sample collections of plasma and caecal contents After the last treatment of modelling, rats were immediately deprived of food but were allowed freely to drink. Afterward, faecal samples were collected for 12 h via metabolic cages.…”

Section: Animals and Experimental Designmentioning

confidence: 99%

Microbiome and metabolome reveal the metabolic and microbial variations induced by depression and constipation

et al. 2023

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Background Depressed patients are often accompanied with constipation symptoms, and vice versa. However, the underlying mechanisms of such a bidirectional correlation have remained elusive. We aim to reveal the possible correlations between depression and constipation from the perspectives of gut microbiome and plasma metabolome. Methods We constructed the depressed model and the constipated model of rats, respectively. First, we measured the locomotor activity status and the gastrointestinal functions of rats. And then, nuclear magnetic resonance plasma metabolomics was applied to reveal the shared and the unique metabolites of depression and constipation. In addition, 16 S ribosomal RNA gene sequencing was used to detect the impacts of constipation and depression on gut microbiota of rats. Finally, a multiscale and multifactorial network, that is, the ‘phenotypes ‐ differential metabolites ‐ microbial biomarkers’ integrated network, was constructed to visualise the mechanisms of connections between depression and constipation. Results We found that spontaneous locomotor activity and gastrointestinal functions of both depressed rats and constipated rats significantly decreased. Further, eight metabolites and 14 metabolites were associated depression and constipation, respectively. Among them, seven metabolites and four metabolic pathways were shared by constipation and depression, mainly perturbing energy metabolism and amino acid metabolism. Additionally, depression and constipation significantly disordered the functions and the compositions of gut microbiota of rats, and decreased the ratio of Firmicutes to Bacteroidetes. Conclusion The current findings provide multiscale and multifactorial perspectives for understanding the correlations between depression and constipation, and demonstrate new mechanisms of comorbidity of depression and constipation.

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Fecal Metabolomics and Network Pharmacology Reveal the Correlations between Constipation and Depression

Cited by 17 publications

References 38 publications

The connections of physical and psychosocial symptoms among patients with terminal illnesses: A network analysis

The connections of physical and psychosocial symptoms among patients with terminal illnesses: A network analysis

Association of sleep duration with chronic constipation among adult men and women: Findings from the National Health and Nutrition Examination Survey (2005–2010)

Microbiome and metabolome reveal the metabolic and microbial variations induced by depression and constipation

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