Fecal microbiota relationships with childhood obesity: A scoping comprehensive review

Cuevillas, Begoña de; Milagro, Fermı́n I.; Tur, Josep A.; Gil‐Campos, Mercedes; Miguel-Etayo, Pilar De; Martínéz, J. Alfredo; Navas‐Carretero, Santiago

doi:10.1111/obr.13394

Cited by 19 publications

(10 citation statements)

References 142 publications

(243 reference statements)

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“…In a first step, we observed lower microbial a-diversity in APexposed individuals independent of the BMI index, indicating that a reduction in bacterial richness is associated with psychiatric (Jiang et al, 2018;Jiang et al, 2020) and metabolic diseases (de Cuevillas et al, 2022;Zheng et al, 2022). These results were consistent with Flowers et al (2017), who used 16S ribosomal sequences from 117 adult bipolar disorder patients (49 AP treated and 68 non-AP treated).…”

Section: Discussionsupporting

confidence: 86%

Gut microbiome profiles may be related to atypical antipsychotic associated overweight in Asian children with psychiatric disorder: a preliminary study

Hao

Zhou

Zhang

et al. 2023

Front. Cell. Infect. Microbiol.

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ObjectiveAtypical antipsychotics (APs) modify the gut microbiome, and weight gain in response to AP could be mediated by the gut microbiome. Thus, the present study aimed to explore the changes in the gut bacterial microbiome in AP-exposed children with obesity.MethodsTo rule out the confounder of AP indication, the gut bacterial microbiome was compared between healthy controls (Con) and AP-exposed individuals with overweight (APO) or normal weight (APN). Fifty-seven AP-treated outpatients (21 APO and 36 APN) and 25 Con were included in this cross-sectional microbiota study.ResultsAP users, regardless of body mass index, exhibited decreased microbial richness and diversity and a distinct metagenomic composition compared to the Con. Although no differences in the microbiota structure were observed between APO and APN groups, the APO group was characterised by a higher abundance of Megamonas and Lachnospira. Additionally, the differences in the microbial functions were observed between APO and APN groups.ConclusionsThe gut bacterial microbiota of APO children revealed taxonomic and functional differences compared to Con and APN. Further studies are needed to verify these findings and to explore the temporal and causal relationships between these variables.

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Section: Discussionsupporting

confidence: 86%

Gut microbiome profiles may be related to atypical antipsychotic associated overweight in Asian children with psychiatric disorder: a preliminary study

Hao

Zhou

Zhang

et al. 2023

Front. Cell. Infect. Microbiol.

View full text Add to dashboard Cite

show abstract

“…In a rst step, we observed lower microbial α-diversity in AP-exposed individuals independent of the BMI index, indicating that a reduction in bacterial richness is associated with psychiatric [17,18] and metabolic diseases [19,20]. These results were consistent with Flowers et al [11], who used 16S ribosomal sequences from 117 adult bipolar disorder patients (49 AP treated and 68 non-AP treated).…”

Section: Discussionsupporting

confidence: 86%

Gut Microbiome Profiles Are Related to Atypical Antipsychotic Associated Overweight in Asian Children with Psychiatric Disorder

Hao

Zhou

Zhang

et al. 2022

Preprint

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Atypical antipsychotics (APs) modify the gut microbiome, and weight gain in response to AP could be mediated by the gut microbiome. Thus, the present study aimed to explore the changes in the gut bacterial microbiome in AP-exposed children with obesity. To rule out the confounder of AP indication, the gut bacterial microbiome was compared between healthy controls (Con) and AP-exposed individuals with overweight (APO) or normal weight (APN). Fifty-seven AP-treated outpatients (21 APO and 36 APN) and 25 Con were included in this cross-sectional microbiota study. AP users, regardless of body mass index, exhibited decreased microbial richness and diversity and a distinct metagenomic composition compared to the Con. Although no differences in the microbiota structure were observed between APO and APN groups, the APO group was characterised by a higher abundance of Megamonas and Lachnospira. Additionally, the differences in the microbial functions were observed between APO and APN groups. The gut bacterial microbiota of APO children revealed taxonomic and functional differences compared to Con and APN. Further studies are needed to verify these findings and to explore the temporal and causal relationships between these variables.

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“…patterns, seem to contribute to childhood obesity. 62,63) Maternal gestational weight gain influences gut microbiota acquisition, composition, and microbial activity during early infancy. 64) Maternal diet during gestation and lactation modulates the abundance and prevalence of the infant's microbiota, thus changing the bacterial pool transferred to the offspring during pregnancy and early life.…”

Section: A C C E P T E D a R T I C L Ementioning

confidence: 99%

Association of gut microbiota with obesity in children and adolescents

CHO

2023

Clin Exp Pediatr

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Pediatric obesity is among the most serious global health problems whose prevalence has increased over the past decade. Pediatric obesity increases concomitant health problems, including type 2 diabetes mellitus, hypertension, dyslipidemia, fatty liver disease, and psychological problems, which often progress into adulthood. The gut microbiota is a new factor in the development of obesity, which is affected by renowned risk factors such as diet, lifestyle, and socioeconomic status. This review aimed to describe the association between the gut microbiota and childhood obesity. According to advances in gene sequencing technologies, many findings of experimental animal and human studies of adults and children demonstrated that compositional and functional changes in the gut microbiota (dysbiosis) are associated with the development of obesity. Many studies have reported that an increased Firmicutes/Bacteroidetes (F/B) ratio is a biomarker of obesity susceptibility; however, with the rapid accumulation of data, meta-analyses of human gut microbiota and obesity showed no clear association between F/B ratio and obesity status. The contribution of the microbiota to obesity has been considered using multifactorial approaches, such as supplying additional calories to the host, modulating blood lipopolysaccharide levels, favoring fat storage, and affecting satiety. Probiotics are proposed to manipulate the gut microbiota population to improve obesity; however, their clinical application remains limited because trials have shown different results. Further studies are required to better understand the mechanisms underlying the observed association between the gut microbiota and pediatric obesity.

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Fecal microbiota relationships with childhood obesity: A scoping comprehensive review

Cited by 19 publications

References 142 publications

Gut microbiome profiles may be related to atypical antipsychotic associated overweight in Asian children with psychiatric disorder: a preliminary study

Gut microbiome profiles may be related to atypical antipsychotic associated overweight in Asian children with psychiatric disorder: a preliminary study

Gut Microbiome Profiles Are Related to Atypical Antipsychotic Associated Overweight in Asian Children with Psychiatric Disorder

Association of gut microbiota with obesity in children and adolescents

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