Fecal Microbiota Transplantation: A New Therapeutic Attempt from the Gut to the Brain

Xu, Haoming; Huang, Honglan; Zhou, Youlian; Zhao, Hailan; Xu, Jing; Shou, Diwen; Liu, Yan-Di; Zhou, Yongjian; Nie, Yuqiang

doi:10.1155/2021/6699268

Cited by 71 publications

(45 citation statements)

References 179 publications

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“…In this study, we assessed the effect of PS128 on the icv-STZ-treated 3 × Tg-AD model and showed that longterm supplementation with PS128 prevented cognitive dysfunction induced by icv-STZ in the 3 × Tg-AD male mice. The beneficial effects of PS128 supplementation on attenuating cognitive deficits were consistent with many other probiotic studies [14,[64][65][66][67]. Therefore, we suggest that PS128 supplementation is safe and has the potential to prevent cognitive dysfunction in individuals with AD.…”

Section: Discussionsupporting

confidence: 89%

Lactobacillus plantarum PS128 prevents cognitive dysfunction in Alzheimer’s disease mice by modulating propionic acid levels, glycogen synthase kinase 3 beta activity, and gliosis

Huang

Chen

Liao

et al. 2021

BMC Complement Med Ther

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Background According to recent evidence, psychobiotics exert beneficial effects on central nervous system-related diseases, such as mental disorders. Lactobacillus plantarum PS128 (PS128), a novel psychobiotic strain, improves motor function, depression, and anxiety behaviors. However, the psychobiotic effects and mechanisms of PS128 in Alzheimer’s disease (AD) remain to be explored. Objectives The goal of the current study was to evaluate the beneficial effects of PS128 and to further elucidate its mechanism in AD mice. Methods PS128 (1010 colony-forming unit (CFU)/ml) was administered via oral gavage (o.g.) to 6-month-old male wild-type B6 and 3 × Tg-AD mice (harboring the PS1M146V, APPswe and TauP30IL transgenes) that received an intracerebroventricular injection of streptozotocin (icv-STZ, 3 mg/kg) or vehicle (saline) for 33 days. After serial behavioral tests, fecal short-chain fatty acid levels and AD-related pathology were assessed in these mice. Results Our findings show that intracerebroventricular injection of streptozotocin accelerated cognitive dysfunction associated with increasing levels of glycogen synthase kinase 3 beta (GSK3β) activity, tau protein phosphorylation at the T231 site (pT231), amyloid-β (Aβ) deposition, amyloid-β protein precursor (AβPP), β-site AβPP-cleaving enzyme (BACE1), gliosis, fecal propionic acid (PPA) levels and cognition-related neuronal loss and decreasing postsynaptic density protein 95 (PSD95) levels in 3 × Tg-AD mice. PS128 supplementation effectively prevented the damage induced by intracerebroventricular injection of streptozotocin in 3 × Tg-AD mice. Conclusions Based on the experimental results, intracerebroventricular injection of streptozotocin accelerates the progression of AD in the 3 × Tg-AD mice, primarily by increasing the levels of gliosis, which were mediated by the propionic acid and glycogen synthase kinase 3 beta pathways. PS128 supplementation prevents damage induced by intracerebroventricular injection of streptozotocin by regulating the propionic acid levels, glycogen synthase kinase 3 beta activity, and gliosis in 3 × Tg-AD mice. Therefore, we suggest that PS128 supplementation is a potential strategy to prevent and/or delay the progression of AD.

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Section: Discussionsupporting

confidence: 89%

Lactobacillus plantarum PS128 prevents cognitive dysfunction in Alzheimer’s disease mice by modulating propionic acid levels, glycogen synthase kinase 3 beta activity, and gliosis

Huang

Chen

Liao

et al. 2021

BMC Complement Med Ther

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“…Fecal microbiota transplant (FMT) enables the gut microbiota composition to be reconstructed; it is a transfer of gut microbiota from a healthy individual to a patient suffering from a certain disease. FMT has proved to have be effective in recurrent Clostridium difficile infection [ 79 ]. So far, only one case of a 36-year-old male patient suffering from severe plaque psoriasis for 10 years as well as inflammatory bowel disease for 15 years who had undergone two FMTs five weeks apart has been described in China.…”

Section: Discussionmentioning

confidence: 99%

Psoriasis and Gut Microbiome—Current State of Art

Polak

Bergler‐Czop

Szczepanek

et al. 2021

IJMS

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Psoriasis is a chronic, immune-mediated inflammatory disease that affects around 125 million people worldwide. Several studies concerning the gut microbiota composition and its role in disease pathogenesis recently demonstrated significant alterations among psoriatic patients. Certain parameters such as Firmicutes/Bacteroidetes ratio or Psoriasis Microbiome Index were developed in order to distinguish between psoriatic and healthy individuals. The “leaky gut syndrome” and bacterial translocation is considered by some authors as a triggering factor for the onset of the disease, as it promotes chronic systemic inflammation. The alterations were also found to resemble those in inflammatory bowel diseases, obesity and certain cardiovascular diseases. Microbiota dysbiosis, depletion in SCFAs production, increased amount of produced TMAO, dysregulation of the pathways affecting the balance between lymphocytes populations seem to be the most significant findings concerning gut physiology in psoriatic patients. The gut microbiota may serve as a potential response-to-treatment biomarker in certain cases of biological treatment. Oral probiotics administration as well as fecal microbial transplantation were most reported in bringing health benefits to psoriatic patients. However, the issue of psoriatic bacterial gut composition, its role and healing potential needs further investigation. Here we reviewed the literature on the current state of the relationship between psoriasis and gut microbiome.

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“…In conclusion, although our results indicate that prolonged dietary intervention with polyphenol enriched nutritional regimes does not significantly impact the offspring microbiota, we observed significant dysbiosis reduction mainly at weaning time, indicating that the reduction of mothers’ dysbiosis may beneficially affect babies’ microbiota and help preventing/reducing IBD development. Nutrition should become a common adjuvant therapy for dysbiosis mediated inflammatory disorders that may evolve in intestinal or extraintestinal disorders ( Ianiro et al., 2020 ; De Santis et al., 2021 ; Xu et al., 2021 ). Based on these results, the present study can contribute to pave the way for future studies based on nutritional interventions designed for IBD mothers.…”

Section: Discussionmentioning

confidence: 99%

Polyphenol Enriched Diet Administration During Pregnancy and Lactation Prevents Dysbiosis in Ulcerative Colitis Predisposed Littermates

Santis

Scarano

Liso

et al. 2021

Front. Cell. Infect. Microbiol.

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Neonatal colonization of the gastrointestinal tract depends on mother microbiome, thus mother microbiota dysbiosis is transmitted to the offspring during the delivery and shaped by breastmilk characteristics. Here we used a murine model of UC predisposition (Winnie-/-) to evaluate the effects of maternal diet during pregnancy and lactation. Using heterozygous breeders, we obtained both Winnie-/- and C57BL/6 littermates from the same mother and compared their microbiota at weaning and adult age, using a diet enriched with 1% tomato fruit of a line – named Bronze – highly enriched in bioactive polyphenols, or Control tomato. Females received enriched diets two weeks before the beginning of the breeding and never stopped for the following six months. No significant effect was observed in regard to the percentage of Winnie-/- offspring, as with both diets the percentage was about 25% as expected. Winnie littermates from breeders fed with the Bronze-enriched diet showed reduced dysbiosis at 4 weeks of age if compared with Winnie under the Control tomato diet. This effect was then reduced when mice reached adult age. Conversely, the microbiota of C57BL/6 does not change significantly, indicating that fortified mothers-diet significantly contribute to preventing dysbiosis in genetically predisposed offspring, but has mild effects on healthy littermates and adult mice. An overall tendency towards reduced inflammation was underlined by the colon weight and the percentage of Foxp3+ cells reduction in Winnie mice fed with Bronze diet. Control diet did not show similar tendency.

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Fecal Microbiota Transplantation: A New Therapeutic Attempt from the Gut to the Brain

Cited by 71 publications

References 179 publications

Lactobacillus plantarum PS128 prevents cognitive dysfunction in Alzheimer’s disease mice by modulating propionic acid levels, glycogen synthase kinase 3 beta activity, and gliosis

Lactobacillus plantarum PS128 prevents cognitive dysfunction in Alzheimer’s disease mice by modulating propionic acid levels, glycogen synthase kinase 3 beta activity, and gliosis

Psoriasis and Gut Microbiome—Current State of Art

Polyphenol Enriched Diet Administration During Pregnancy and Lactation Prevents Dysbiosis in Ulcerative Colitis Predisposed Littermates

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