Fecal microbiota transplantation ameliorates stress-induced depression-like behaviors associated with the inhibition of glial and NLRP3 inflammasome in rat brain

Rao, Jingjing; Qiao, Yi; Xie, Ruining; Lin, Li; Jiang, Jian Hong; Wang, Chunmei; Li, Gongying

doi:10.1016/j.jpsychires.2021.02.057

Cited by 64 publications

(34 citation statements)

References 46 publications

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“…However, due to possible safety risks and other unknowns, studies investigating the efficacy of FMTs in psychiatric disorders are at very early stages. Data from animal models showing that FMT can be efficacious in reversing adverse behaviors and neuroinflammation and improve anxiety- and depression-like behavior [ 37 ▪ , 38 ] are establishing a promising basis for clinical trials. However, most human studies to date have been small or case control studies [ 39 ]; only one larger human trial including 83 patients with inflammatory bowel disease and co-morbid self-reported depression reported significant improvements in fatigue after FMT [ 40 ▪▪ ].…”

Section: Fecal Microbial Transplantmentioning

confidence: 99%

Microbiota-targeted interventions for mental health

Berding

Cryan

2021

Current Opinion in Psychiatry

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Purpose of review The gut microbiota has emerged as a key conduit in mental health and is a promising target for interventions. This review provides an update on recent advances in using microbiota-targeted approaches for the management of mental health. Recent findings Approaches that have emerged as microbiota-targeted interventions in the management of mental health include probiotics, prebiotics, synbiotics, fecal microbiota transplant as well as diet. Among these approaches, probiotic supplementation has been investigated most prominently, providing promising evidence for its use in improving mood and anxiety. There is also growing interest in the use of multistrain probiotics, whole dietary interventions or combined approaches, with encouraging results emerging from recent studies. Summary Although the current literature preliminarily supports targeting the microbiota to manage mental health and use as adjuvant therapies for certain brain disorders, large gaps remain and especially data including clinical cohorts remains scarce. Research studies including larger cohorts, well-characterized clinical populations and defined duration and dosage of the intervention are required to develop evidence-based guidelines for microbiota-targeted strategies.

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Section: Fecal Microbial Transplantmentioning

confidence: 99%

Microbiota-targeted interventions for mental health

Berding

Cryan

2021

Current Opinion in Psychiatry

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“…With the development of molecular biology and genetic engineering technology and the further research on the regulatory genes and PD therapy in the process of NSCs differentiating into dopaminergic neurons and making full use of the synergistic and complementary effects of these regulatory genes, it is believed that, in the near future, NSCs can be induced to differentiate into dopaminergic neurons efficiently by artificially controlling various factors of NSCs differentiation. It can effectively improve the effect of PD gene therapy and further promote the development of its clinical application, so as to relieve the pain of PD patients more effectively [ 21 , 22 ].…”

Section: Morphine Addiction and Stress-induced Depressionmentioning

confidence: 99%

Mechanism of Dopaminergic Nerve Transmission in Different Doses of Morphine Addiction and Stress-Induced Depression

2021

Journal of Healthcare Engineering

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Depression not only threatens the health and quality of life of patients but also brings a huge mental and economic burden to the patients’ families. This paper mainly studies the mechanism of dopaminergic neurotransmission in different doses of morphine addiction and stress-induced depression. In the experiment, 40 male SD rats were selected. The experiment established a rat model of chronic stress depression. The rats used in this model are all raised in a single cage, and there will be various stimuli every day for 21 days, but high-intensity continuous stimuli must be avoided, and the same stimuli will not appear continuously. The experiment established a depression animal model through chronic unpredictable mild stress (CUMS), combined with the conditioned position preference (CPP) model of morphine addiction to detect the establishment of CPP in such animals, so as to explore certain stress stimuli or depression, the influence on morphine addiction, and the relationship between them. The second or third branches of pyramidal neurons were selected to analyze the PL and CA3 regions. When analyzing the density of dendrites, each animal selected at least 8 dendrites in order to count the number of dendrites and selected a length of 20 μm on each branch to record the number of dendrites. All measured values are expressed as average ± standard deviation and analyzed by SPSS17.0 statistical software, and Levene test is used in the scattered consistency test. The average NIV of PEN before injection was 11.92 ± 2.90 Hz, and the average latency was 0.16 ± 0.03 s. The results indicate that CUMS may reduce the conditioned learning and memory ability by damaging the learning loop, rather than affecting the reward loop to weaken the establishment of morphine-dependent CPP.

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“…Under stress and depression, the gut microbiota can become disorganized, having a negative effect on the central nervous system and worsening the disease. However, FMT has shown outstanding results in the treatment of microbial structural disorders [ 117 ] and depression [ 118 , 119 ], also reprogramming the host’s metabolism [ 120 ]. Geng et al have announced that FMT can regulate the diversity and ecosystem structure of colon microbiota, reduce the intestinal epithelial validation response, and reduce the host inflammatory response.…”

Section: Treatments Of Depressionmentioning

confidence: 99%

The Microbiota–Gut–Brain Axis in Depression: The Potential Pathophysiological Mechanisms and Microbiota Combined Antidepression Effect

Zhu

Chen

2022

Nutrients

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Depression is a kind of worldwide mental illness with the highest morbidity and disability rate, which is often accompanied by gastrointestinal symptoms. Experiments have demonstrated that the disorder of the intestinal microbial system structure plays a crucial role in depression. The gut–brain axis manifests a potential linkage between the digestion system and the central nervous system (CNS). Nowadays, it has become an emerging trend to treat diseases by targeting intestinal microorganisms (e.g., probiotics) and combining the gut–brain axis mechanism. Combined with the research, we found that the incidence of depression is closely linked to the gut microbiota. Moreover, the transformation of the gut microbiota system structure is considered to have both positive and negative regulatory effects on the development of depression. This article reviewed the mechanism of bidirectional interaction in the gut–brain axis and existing symptom-relieving measures and antidepression treatments related to the gut microbiome.

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Fecal microbiota transplantation ameliorates stress-induced depression-like behaviors associated with the inhibition of glial and NLRP3 inflammasome in rat brain

Cited by 64 publications

References 46 publications

Microbiota-targeted interventions for mental health

Microbiota-targeted interventions for mental health

Mechanism of Dopaminergic Nerve Transmission in Different Doses of Morphine Addiction and Stress-Induced Depression

The Microbiota–Gut–Brain Axis in Depression: The Potential Pathophysiological Mechanisms and Microbiota Combined Antidepression Effect

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