Fecal microbiota transplantation as a method to treat complications after hematopoietic stem cell transplantation

Kucher, Maxim A.; Goloschapov, O. V.; Moiseev, Ivan S.; Afanasyev, Boris

doi:10.18620/ctt-1866-8836-2017-6-1-20-29

Cited by 5 publications

(4 citation statements)

References 24 publications

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“…There is also evidence of FMT efficacy in correcting microbiota following antibacterial treatment [10]. A number of published data provide evidence for the effectiveness of FMT in complex therapy of autoimmune diseases [11], antibiotic-associated diarrhea, and in graft-versus-host disease occurring after hematopoietic stem cell transplantation [12, 13]. The FMT procedure results in reduced prevalence of gut Enterobacteriaceae with multiple resistance to beta-lactam antibiotics and carbapenems, vancomycin-resistant Enterococcus spp.…”

Section: Introductionmentioning

confidence: 99%

Long-term impact of fecal transplantation in healthy volunteers

et al. 2019

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BackgroundFecal microbiota transplantation (FMT) has been recently approved by FDA for the treatment of refractory recurrent clostridial colitis (rCDI). Success of FTM in treatment of rCDI led to a number of studies investigating the effectiveness of its application in the other gastrointestinal diseases. However, in the majority of studies the effects of FMT were evaluated on the patients with initially altered microbiota. The aim of our study was to estimate effects of FMT on the gut microbiota composition in healthy volunteers and to monitor its long-term outcomes.ResultsWe have performed a combined analysis of three healthy volunteers before and after capsule FMT by evaluating their general condition, adverse clinical effects, changes of basic laboratory parameters, and several immune markers. Intestinal microbiota samples were evaluated by 16S rRNA gene and shotgun sequencing. The data analysis demonstrated profound shift towards the donor microbiota taxonomic composition in all volunteers. Following FMT, all the volunteers exhibited gut colonization with donor gut bacteria and persistence of this effect for almost ∼1 year of observation. Transient changes of immune parameters were consistent with suppression of T-cell cytotoxicity. FMT was well tolerated with mild gastrointestinal adverse events, however, one volunteer developed a systemic inflammatory response syndrome.ConclusionsThe FMT leads to significant long-term changes of the gut microbiota in healthy volunteers with the shift towards donor microbiota composition and represents a relatively safe procedure to the recipients without long-term adverse events.

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Section: Introductionmentioning

confidence: 99%

Long-term impact of fecal transplantation in healthy volunteers

et al. 2019

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“…The most differentially represented taxa at the genus level were Acinetobacter, showing SA and SNZ gene distribution. As opportunistic pathogens, proteobacteria, actinobacteria, and bacteroidia are associated with kidney infection in individuals with underlying medical risk factors, such as diabetes mellitus and immunosuppression [35][36][37][38][39]. Interestingly, the abundance of proteobacteria, actinobacteria, and bacteroidia were higher in the SNZ and SA.…”

Section: Discussionmentioning

confidence: 99%

Kidney microbiome in patients with kidney carcinoma: Role of SA and SNZ gene expression

Yin

Zhang

et al. 2021

Arch Med Sci

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IntroductionA kidney tumor is among the 10 most common cancers. Among kidney tumors, renal cell carcinoma (RCC) is one of the most common types with an alarming increasing incidence rate. Although the disruption of microbiota is an established factor in the progression of intestinal cancers, its role in other types of cancers has been under-studied.Material and methodsIn this study, the microbiome disruption and the involvement of SNZ (SCHNARCHZAPFEN) and SA (Stromalin) genes in the development of kidney cancer have been focused on using a combination of genetic and bioinformatic analysis. The microbiomes of kidney tumor patients were analyzed using various genetic and bioinformatic variations. Genetic and bioinformatic analyses were performed to identify operational taxonomic units (OTUs), SNZ, SA, and annotate species were determined using 41 samples from a population of kidney tumors.ResultsThe whole samples from the kidney tumor of patients were screened by PCR amplification and a total of 1317 OTUs were identified. Among them, 379 were common among the two populations, 766 were unique to the SA gene, and 172 to SNZ. SA was more abundant in Gammaproteobacteria and bacilli, while SNZ had a higher abundance in bacteroidia and actinobacteria. Correlation analysis was performed to find out the bacteria that were differentially expressed among the population samples.ConclusionsTo sum up, our study reveals that SA and SNZ are differentially expressed in the microbiome of the kidney tumor that is associated with the development of kidney tumors such as renal cell carcinoma in human populations.

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“…In most of the patients treated by FMT, fast clinical response was observed, along with positive dynamics of microbial fl ora in their stool samples. Our further studies are aiming to extend indications for FMT usage aft er allo-HSCT, in order to treat bacterial complications and immune disturbances (i.e., graft -versus-host disease) which suffi ciently depends on gut microbiota changes [86].…”

Section: Probiotics and Fecal Transplantation Post-hsctmentioning

confidence: 99%