Fecal microbiota transplantation associated with 10 years of stability in a patient with SPMS

Makkawi, Seraj; Cámara-Lemarroy, Carlos R.; Metz, Luanne M.

doi:10.1212/nxi.0000000000000459

Cited by 118 publications

(75 citation statements)

References 6 publications

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“…One secondary progressive MS patient was treated with a single FMT for concomitant recurrent Clostridioides difficile infections. The FMT resolved the recurrent C. difficile infections and was suggested to prevent MS disease progression for over 10 years (Makkawi et al, 2018). In the case-series amelioration of MS symptoms following repeated FMTs was observed in three patients (Borody et al, 2011).…”

Section: Role Of the Gut Microbiota In Disease Symptoms And Pathogenesismentioning

confidence: 94%

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Fecal Microbiota Transplantation in Neurological Disorders

Vendrik

Ooijevaar

Jong

et al. 2020

Front. Cell. Infect. Microbiol.

280

174

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Conclusions: Preliminary literature suggests that FMT may be a promising treatment option for several neurological disorders. However, available evidence is still scanty and some contrasting results were observed. A limited number of studies in humans have been performed or are ongoing, while for some disorders only animal experiments have been conducted. Large double-blinded randomized controlled trials are needed to further elucidate the effect of FMT in neurological disorders.

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Section: Role Of the Gut Microbiota In Disease Symptoms And Pathogenesismentioning

confidence: 94%

“…FMT studies in patients ( Table 2) Currently, there are only two case reports/series on effects of FMT on MS symptoms and disease progression (Borody et al, 2011;Makkawi et al, 2018). Both claim sustained beneficial effects following FMT.…”

Section: Role Of the Gut Microbiota In Disease Symptoms And Pathogenesismentioning

confidence: 99%

Fecal Microbiota Transplantation in Neurological Disorders

Vendrik

Ooijevaar

Jong

et al. 2020

Front. Cell. Infect. Microbiol.

280

174

View full text Add to dashboard Cite

show abstract

“…sclerosis (MS) (85)(86)(87)(88)(89)(90). In addition, preclinical evidence suggests that targeting the microbiota may be beneficial for many other disorders.…”

Section: Other Potential Future Indicationsmentioning

confidence: 99%

“…Microbiota involvement in the pathogenesis of MS is suggested by two studies showing an increase in disease incidence or severity in an MS murine model when FMT was performed with stool samples acquired from MS patients (93,94). Finally, case reports have described promising results of FMT in MS patients (85,88), although these results should be interpreted with caution.…”

Section: Other Potential Future Indicationsmentioning

confidence: 99%

Clinical Application and Potential of Fecal Microbiota Transplantation

et al. 2019

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Fecal microbiota transplantation (FMT) is a well-established treatment for recurrent Clostridioides difficile infection. FMT has become a more readily available and useful new treatment option as a result of stool banks. The current state of knowledge indicates that dysbiosis of the gut microbiota is implicated in several disorders in addition to C. difficile infection. Randomized controlled studies have shown FMT to be somewhat effective in treating ulcerative colitis, irritable bowel syndrome, and hepatic encephalopathy. In addition, FMT has been beneficial in treating several other conditions, such as the eradication of multidrug-resistant organisms and graft-versus-host disease. We expect that FMT will soon be implemented as a treatment strategy for several new indications, although further studies are needed.

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“…FMT are most commonly accomplished via endoscopies, enemas, and oral feeding of freeze-dried material. Aside from GI and psychiatric disorders, this treatment method is also being explored as a potential treatment for metabolic disorders, autism, multiple sclerosis, and Parkinson's disease (de Groot et al, 2017;Kang et al, 2017;Makkawi et al, 2018). Other variations of this treatment, such as Microbial Ecosystem Therapeutics-2 (MET-2) are also currently being explored, in psychiatric indications such as Generalized Anxiety (GAD) and Major Depressive Disorders (MDD).…”

Section: Fecal Microbiota Transplantmentioning

confidence: 99%

Effect of Fecal Microbiota Transplant on Symptoms of Psychiatric Disorders: A Systematic Review

Meyyappan

Forth

Wallace

et al. 2020

Preprint

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Background: The Gut-Brain-Axis is a bidirectional signaling pathway between the gastrointestinal (GI) tract and the brain. The hundreds of trillions of microorganisms populating the gastrointestinal tract are thought to modulate this connection, and have far reaching effects on the immune system, central and autonomic nervous systems, and GI functioning. These interactions have also been linked to various psychiatric illnesses such as depression, anxiety, substance abuse, and eating disorders. It is hypothesized that techniques aimed at strengthening and repopulating the gut microbiome, such as Fecal Microbiota Transplant (FMT), may be useful in the prevention and treatment of psychiatric illnesses. Methods: A systematic search of five databases was conducted using key terms related to FMT and psychiatric illnesses. All results were then evaluated based on specific eligibility criteria. Results: Twenty-one studies met the eligibility criteria and were analysed for reported changes in mood and behavioural measures indicative of psychiatric wellbeing. The studies included were either entirely clinical (n=7), preclinical with human donors (n=7), or entirely preclinical (n=7). All studies found a decrease in depressive and anxiety-like symptoms and behaviours resulting from the transplantation of healthy microbiota. The inverse was also found, with the transmission of depressive and anxiety-like symptoms and behaviours resulting from the transplantation of microbiota from psychiatrically ill donors to healthy recipients. Conclusion: There appears to be strong evidence for the treatment and transmission of psychiatric illnesses through FMT. Further research with larger sample sizes and stronger scientific design is warranted in order to fully determine the efficacy and safety of this potential treatment.

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Fecal microbiota transplantation associated with 10 years of stability in a patient with SPMS

Cited by 118 publications

References 6 publications

Fecal Microbiota Transplantation in Neurological Disorders

Fecal Microbiota Transplantation in Neurological Disorders

Clinical Application and Potential of Fecal Microbiota Transplantation

Effect of Fecal Microbiota Transplant on Symptoms of Psychiatric Disorders: A Systematic Review

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