2018
DOI: 10.1056/nejmc1803103
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Fecal Microbiota Transplantation for Primary Clostridium difficile Infection

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Cited by 196 publications
(157 citation statements)
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“…the availability of defined microbiota rodent models offers unique opportunities to study hostemicrobiota interactions well beyond what may have been envisioned by Schaedler in 1965. " In fact, the current use of fecal transplantation in the treatment of primary Clostridium difficile infection as a cause of pseudomembranous colitis in humans is just one example (Gustafsson et al, 1999;Juul et al, 2018).…”
Section: Production Of Defined Microbiome Ratsmentioning
confidence: 99%
“…the availability of defined microbiota rodent models offers unique opportunities to study hostemicrobiota interactions well beyond what may have been envisioned by Schaedler in 1965. " In fact, the current use of fecal transplantation in the treatment of primary Clostridium difficile infection as a cause of pseudomembranous colitis in humans is just one example (Gustafsson et al, 1999;Juul et al, 2018).…”
Section: Production Of Defined Microbiome Ratsmentioning
confidence: 99%
“…Conventionally, antibiotics with metronidazole or vancomycin is the first‐line treatment to eradicate gut CDI, but 15% to 30% of patients experience recurrence, largely attributed to the persistence of C difficile spores. FMT, attempting to restore normal gut microbiota, is a reasonable treatment for primary CDI, but still under a phase III trial . Recurrence CDI became a clinical challenge because of declining efficacy of conventional antibiotics treatment with 40% to 60% recurrence rate .…”
Section: Clinical Applicationmentioning
confidence: 99%
“…FMT, attempting to restore normal gut microbiota, is a reasonable treatment for primary CDI, but still under a phase III trial. 26 Recurrence CDI became a clinical challenge because of declining efficacy of conventional antibiotics treatment with 40% to 60% recurrence rate. 27 The first report of FMT in recurrence CDI was reported by Schwan et al in 1983 with retention enema.…”
Section: Adverse Eventsmentioning
confidence: 99%
“…von in Kapseln eingebrachtem Spenderstuhl wird die Akzeptanz und Praktikabilität dieser im Prinzip nicht neuen, aber sicherlich zukunftsträchtigen therapeutischen Maßnahme wesentlich steigern [43]. …”
Section: Glutamin Glutamin Wurde Bei Kritischunclassified