Fecal Microbiota Transplantation in Inflammatory Bowel Disease

Boicean, Adrian; Bîrluțiu, Victoria; Ichim, Cristian; Anderco, Paula; Birsan, Sabrina

doi:10.3390/biomedicines11041016

Cited by 33 publications

(31 citation statements)

References 71 publications

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“…In recent years, fecal microbiota transplantation (FMT), a treatment centered on the microbiome, has garnered significant attention across scientific, clinical, and public audiences [ 288 ]. Using a range of techniques and methods, FMT is a complex procedure aimed at reinstating a harmonious intestinal flora.…”

Section: Future Perspectives Regarding the Interaction Between Stress...mentioning

confidence: 99%

The Interaction between Stress and Inflammatory Bowel Disease in Pediatric and Adult Patients

Belei,

Basaca,

Olariu

et al. 2024

JCM

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Background: Inflammatory bowel diseases (IBDs) have seen an exponential increase in incidence, particularly among pediatric patients. Psychological stress is a significant risk factor influencing the disease course. This review assesses the interaction between stress and disease progression, focusing on articles that quantified inflammatory markers in IBD patients exposed to varying degrees of psychological stress. Methods: A systematic narrative literature review was conducted, focusing on the interaction between IBD and stress among adult and pediatric patients, as well as animal subjects. The research involved searching PubMed, Scopus, Medline, and Cochrane Library databases from 2000 to December 2023. Results: The interplay between the intestinal immunity response, the nervous system, and psychological disorders, known as the gut–brain axis, plays a major role in IBD pathophysiology. Various types of stressors alter gut mucosal integrity through different pathways, increasing gut mucosa permeability and promoting bacterial translocation. A denser microbial load in the gut wall emphasizes cytokine production, worsening the disease course. The risk of developing depression and anxiety is higher in IBD patients compared with the general population, and stress is a significant trigger for inducing acute flares of the disease. Conclusions: Further large studies should be conducted to assess the relationship between stressors, psychological disorders, and their impact on the course of IBD. Clinicians involved in the medical care of IBD patients should aim to implement stress reduction practices in addition to pharmacological therapies.

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Section: Future Perspectives Regarding the Interaction Between Stress...mentioning

confidence: 99%

The Interaction between Stress and Inflammatory Bowel Disease in Pediatric and Adult Patients

Belei,

Basaca,

Olariu

et al. 2024

JCM

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“…Notably, these molecules are very important in containing and preventing the spread of Mtb. Studies outline the heightened vulnerability to the spread of atypical mycobacterial infections that present changes in signaling the IL-12/IL-23/IFN-γ pathway, which can result in severe infections and even multidrug resistance among infected patients [ 10 , 11 ].…”

Section: Immunological Interplay: Unraveling the Connection Between T...mentioning

confidence: 99%

“…These receptors are involved in recognizing specific components of a microbial origin, thereby initiating immune responses. Their involvement suggests a shared mechanism in the initial phases of both diseases [ 10 , 12 , 13 ]. Specific populations have shown susceptibility to CD due to the dis-regulation of the NOD2 gene [ 14 ].…”

Section: Immunological Interplay: Unraveling the Connection Between T...mentioning

confidence: 99%

Exploring the Potential of Fecal Microbiota Transplantation as a Therapy in Tuberculosis and Inflammatory Bowel Disease

Boicean,

Bratu,

Fleaca

et al. 2023

Pathogens

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This review explores the potential benefits of fecal microbiota transplantation (FMT) as an adjunct treatment in tuberculosis (TB), drawing parallels from its efficacy in inflammatory bowel disease (IBD). FMT has shown promise in restoring the gut microbial balance and modulating immune responses in IBD patients. Considering the similarities in immunomodulation and dysbiosis between IBD and TB, this review hypothesizes that FMT may offer therapeutic benefits as an adjunct therapy in TB. Methods: We conducted a systematic review of the existing literature on FMT in IBD and TB, highlighting the mechanisms and potential implications of FMT in the therapeutic management of both conditions. The findings contribute to understanding FMT’s potential role in TB treatment and underscore the necessity for future research in this direction to fully leverage its clinical applications. Conclusion: The integration of FMT into the comprehensive management of TB could potentially enhance treatment outcomes, reduce drug resistance, and mitigate the side effects of conventional therapies. Future research endeavors should focus on well-designed clinical trials to develop guidelines concerning the safety and short- and long-term benefits of FMT in TB patients, as well as to assess potential risks.

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“…Patients experience serious discomfort and longterm complications. The two main subtypes are Crohn's disease (CD) and Ulcerative colitis (UC) distinguished by disease location and histology findings [2,3]. Diagnosis of IBDs is challenging [4] and involves a multifaceted approach, including clinical examination and specialized tests such as histology and radiology [5].…”

Section: Introductionmentioning

confidence: 99%

Detection of Ulcerative Colitis Lesions from Weakly Annotated Colonoscopy Videos Using Bounding Boxes

Al-Ali,

Chaussard,

Li-Thiao-Té

et al. 2024

Gastrointestinal Disorders

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Ulcerative colitis is a chronic disease characterized by bleeding and ulcers in the colon. Disease severity assessment via colonoscopy videos is time-consuming and only focuses on the most severe lesions. Automated detection methods enable fine-grained assessment but depend on the training set quality. To suit the local clinical setup, an internal training dataset containing only rough bounding box annotations around lesions was utilized. Following previous works, we propose to use linear models in suitable color spaces to detect lesions. We introduce an efficient sampling scheme for exploring the set of linear classifiers and removing trivial models i.e., those showing zero false negative or positive ratios. Bounding boxes lead to exaggerated false detection ratios due to mislabeled pixels, especially in the corners, resulting in decreased model accuracy. Therefore, we propose to evaluate the model sensitivity on the annotation level instead of the pixel level. Our sampling strategy can eliminate up to 25% of trivial models. Despite the limited quality of annotations, the detectors achieved better performance in comparison with the state-of-the-art methods. When tested on a small subset of endoscopic images, the best models exhibit low variability. However, the inter-patient model performance was variable suggesting that appearance normalization is critical in this context.

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Fecal Microbiota Transplantation in Inflammatory Bowel Disease

Cited by 33 publications

References 71 publications

The Interaction between Stress and Inflammatory Bowel Disease in Pediatric and Adult Patients

The Interaction between Stress and Inflammatory Bowel Disease in Pediatric and Adult Patients

Exploring the Potential of Fecal Microbiota Transplantation as a Therapy in Tuberculosis and Inflammatory Bowel Disease

Detection of Ulcerative Colitis Lesions from Weakly Annotated Colonoscopy Videos Using Bounding Boxes

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