Fecal microbiota transplantation in non-communicable diseases: Recent advances and protocols

Hamamah, Sevag; Gheorghiță, Roxana; Lobiuc, Andrei; Sîrbu, Ioan Ovidiu; Covașă, Mihai

doi:10.3389/fmed.2022.1060581

Cited by 24 publications

(12 citation statements)

References 191 publications

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“…Furthermore, healthcare providers lack knowledge about FMT, necessitating ongoing education [ 22 ]. FMT is also being investigated for treating non-communicable conditions like obesity, diabetes, neuropsychiatric disorders, and more [ 23 ], suggesting its expanding use. In summary, FMT integration into CDI management has transformed treatment and spurred innovation in live bacterial products [ 13 ].…”

Section: Resultsmentioning

confidence: 99%

Clostridioides difficile infection: a changing treatment paradigm

Naser,

AlGashami,

Aljashaami

2024

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Clostridioides difficile infection (CDI) poses a persistent challenge in healthcare, with substantial morbidity and mortality implications. This comprehensive review explores current CDI management, emphasising guidelines from IDSA, SHEA, and ESCMID. Additionally, this study spotlights recent drug developments that have the potential to reshape CDI treatment paradigms. Within the current treatment landscape, fidaxomicin, vancomycin, bezlotoxumab, and faecal microbiota transplantation offer varied options, each with its unique strengths and limitations. Fidaxomicin, effective yet resource-constrained, presents a dilemma, with vancomycin emerging as a pragmatic alternative. Bezlotoxumab, though augmenting antibiotics, grapples with cost and safety concerns. Meanwhile, faecal microbiota transplantation, highly efficacious, confronts evolving safety considerations. The horizon of CDI treatment also features promising therapies such as SER-109 and Rebyota, epitomising the evolving paradigm. As CDI management advances, the critical role of standardised microbiome restoration therapies becomes evident, ensuring long-term safety and diversifying treatment strategies.

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Section: Resultsmentioning

confidence: 99%

Clostridioides difficile infection: a changing treatment paradigm

Naser,

AlGashami,

Aljashaami

2024

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“…Fecal microbiota transplantation has recently become a novel method for modulating the gut microbiota in gastrointestinal disorders such as inflammatory bowel syndrome and CDI [ 178 , 179 ], and non-gastrointestinal diseases including neuropsychiatric disorders [ 180 , 181 ]. Fecal microbiota transplantation is a method of directly restoring healthy gut bacteria by transferring stool from a healthy donor.…”

Section: Cecal Microbiota Transplantation Social Stress and Injurious...mentioning

confidence: 99%

The Impact of Early-Life Cecal Microbiota Transplantation on Social Stress and Injurious Behaviors in Egg-Laying Chickens

Fu,

Hu,

Zhang

et al. 2024

Microorganisms

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Injurious behaviors (i.e., aggressive pecking, feather pecking, and cannibalism) in laying hens are a critical issue facing the egg industry due to increased social stress and related health and welfare issues as well as economic losses. In humans, stress-induced dysbiosis increases gut permeability, releasing various neuroactive factors, causing neuroinflammation and related neuropsychiatric disorders via the microbiota–gut–brain axis, and consequently increasing the frequency and intensity of aggression and violent behaviors. Restoration of the imbalanced gut microbial composition has become a novel treatment strategy for mental illnesses, such as depression, anxiety, bipolar disorder, schizophrenia, impulsivity, and compulsivity. A similar function of modulating gut microbial composition following stress challenge may be present in egg-laying chickens. The avian cecum, as a multi-purpose organ, has the greatest bacterial biodiversity (bacterial diversity, richness, and species composition) along the gastrointestinal tract, with vitally important functions in maintaining physiological and behavioral homeostasis, especially during the periods of stress. To identify the effects of the gut microbiome on injurious behaviors in egg-laying chickens, we have designed and tested the effects of transferring cecal contents from two divergently selected inbred chicken lines on social stress and stress-related injurious behaviors in recipient chicks of a commercial layer strain. This article reports the outcomes from a multi-year study on the modification of gut microbiota composition to reduce injurious behaviors in egg-laying chickens. An important discovery of this corpus of experiments is that injurious behaviors in chickens can be reduced or inhibited through modifying the gut microbiota composition and brain serotonergic activities via the gut–brain axis, without donor-recipient genetic effects.

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“…Fecal microbiota transplantation (FMT) is a new treatment for inflammatory bowel disease. FMT is now widely believed to be the transplantation of feces from healthy individuals to the intestinal tract of patients, so as to achieve the purpose of treating diseases by improving and rebuilding the gut microbiota (Hamamah et al, 2022). A previous study demonstrated that the transplantation of fecal flora of healthy mice and Lactobacillus could improve the gut microbiota structure and restore emotional cycle in letrozole induced PCOS rats (Guo et al, 2016).…”

Section: Treatment Of Pcos Based On Gut Microbiome Fecal Microbiota T...mentioning

confidence: 99%

Gut microbiota dysbiosis in polycystic ovary syndrome: Mechanisms of progression and clinical applications

Sun

Gao

et al. 2023

Front. Cell. Infect. Microbiol.

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Polycystic ovary syndrome (PCOS) is the most common endocrine diseases in women of childbearing age that leads to menstrual disorders and infertility. The pathogenesis of PCOS is complex and has not yet been fully clarified. Gut microbiota is associated with disorders of lipid, glucose, and steroid hormone metabolish. A large body of studies demonstrated that gut microbiota could regulate the synthesis and secretion of insulin, and affect androgen metabolism and follicle development, providing us a novel idea for unravelling the pathogenesis of PCOS. The relationship between gut microbiota and the pathogenesis of PCOS is particularly important. This study reviewed recent research advances in the roles of gut microbiota in the occurrence and development of PCOS. It is expected to provide a new direction for the treatment of PCOS based on gut microbiota.

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Fecal microbiota transplantation in non-communicable diseases: Recent advances and protocols

Cited by 24 publications

References 191 publications

Clostridioides difficile infection: a changing treatment paradigm

Clostridioides difficile infection: a changing treatment paradigm

The Impact of Early-Life Cecal Microbiota Transplantation on Social Stress and Injurious Behaviors in Egg-Laying Chickens

Gut microbiota dysbiosis in polycystic ovary syndrome: Mechanisms of progression and clinical applications

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