Fecal microbiota transplantation in the intestinal decolonization of carbapenamase-producing enterobacteriaceae

Silva, João Carlos; Ponte, Ana; Mota, Margarida; Pinho, Rolando; Vieira, Nuno; Oliveira, Rosa de; Mota-Carvalho, Nelson; Gomes, Ana Catarina; Afecto, Edgar; Carvalho, João

doi:10.17235/reed.2020.7150/2020

Cited by 4 publications

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“…investigating post-FMT faecal composition or decolonisation of extra-intestinal sites instead. Finally, a total of 36 studies were included: seven cohort studies [ 22 , 23 ▪ , 24 ▪ , 25 ▪▪ , 26 – 28 ], five case reports [ 29 – 33 ], and 24 ongoing trials.…”

Section: Resultsmentioning

confidence: 99%

“…A total of 254 patients were assessed in the included cohort studies and case reports, with only one study investigating paediatric patients [ 27 ]. Eight studies included immunocompromised patients, mostly undergoing allo-SCT [ 23 ▪ , 24 ▪ , 27 , 29 – 33 ], and three studies included a total of 14 patients with concurrent rCDI [ 24 ▪ , 26 , 28 ]. Although most studies required one positive stool culture or rectal/perianal swab for the definition of colonisation, decolonisation was often confirmed by serial cultures or swabs.…”

Section: Resultsmentioning

confidence: 99%

“…Whereas stool volume varied (from 25 to 100 g), all stool samples were obtained from healthy, unrelated donors, and were mostly frozen. One study [ 27 ] pretreated patients with nonabsorbable antibiotics (oral colistin), and in seven studies patients had used antibiotics in the week prior to FMT [ 24 ▪ , 25 ▪▪ , 26 , 28 , 29 , 31 , 33 ]. Patients were pretreated with PPI in seven studies, and bowel lavage in six studies.…”

Section: Resultsmentioning

confidence: 99%

“…Recolonisation also occurred during antibiotic prophylaxis (for allo-SCT) in an adult patient. [ 30 ] Silva et al [ 28 ], Su et al [ 32 ] and Wang et al [ 33 ] were the only studies in which patients did not receive antibiotics after FMT. Prolonged decolonisation was achieved in four out of five CRE patients in the first study, and in both patients in the case reports.…”

Section: Resultsmentioning

confidence: 99%

“…, 26,28,29,31,33]. Patients were pretreated with PPI in seven studies, and bowel lavage in six studies.…”

Section: Andandmentioning

confidence: 99%

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Faecal microbiota replacement to eradicate antimicrobial resistant bacteria in the intestinal tract – a systematic review

Bilsen¹,

Lambregts²,

Prehn

et al. 2021

Current Opinion in Gastroenterology

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Purpose of review Antimicrobial resistance is a rising threat to global health and is associated with increased mortality. Intestinal colonisation with multidrug-resistant organisms (MDRO) can precede invasive infection and facilitates spread within communities and hospitals. Novel decolonisation strategies, such as faecal microbiota transplantation (FMT), are being explored. The purpose of this review is to provide an update on how the field of FMT for MDRO decolonisation has developed during the past year and to assess the efficacy of FMT for intestinal MDRO decolonisation. Recent findings Since 2020, seven highly heterogenous, small, nonrandomised cohort studies and five case reports have been published. In line with previous literature, decolonisation rates ranged from 20 to 90% between studies and were slightly higher for carbapenem-resistant Enterobacteriaceae than vancomycin-resistant Enterococcus . Despite moderate decolonisation rates in two studies, a reduction in MDRO bloodstream and urinary tract infections was observed. Summary and implications Although a number of smaller cohort studies show some effect of FMT for MDRO decolonisation, questions remain regarding the true efficacy of FMT (taking spontaneous decolonisation into account), the optimal route of administration, the role of antibiotics pre and post-FMT and the efficacy in different patient populations. The observed decrease in MDRO infections post-FMT warrants further research.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

“…, 26,28,29,31,33]. Patients were pretreated with PPI in seven studies, and bowel lavage in six studies.…”

Section: Andandmentioning

confidence: 99%

See 3 more Smart Citations

Faecal microbiota replacement to eradicate antimicrobial resistant bacteria in the intestinal tract – a systematic review

Bilsen¹,

Lambregts²,

Prehn

et al. 2021

Current Opinion in Gastroenterology

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Fecal microbiota transplantation for Carbapenem-Resistant Enterobacteriaceae: A systematic review

Macareño-Castro¹,

Solano-Salazar²,

Dong

et al. 2022

Journal of Infection

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The Relationship Between the Microbiome and Antimicrobial Resistance

Nhu,

Young

2023

Clinical Infectious Diseases

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Antibiotics have benefitted human health since their introduction nearly a century ago. However, the rise of antibiotic resistance may portend the dawn of the “post-antibiotic age.” With the narrow pipeline for novel antimicrobials, we need new approaches to deal with the rise of multidrug resistant organisms. In the last 2 decades, the role of the intestinal microbiota in human health has been acknowledged and studied widely. Of the various activities carried out by the gut microbiota, colonization resistance is a key function that helps maintain homeostasis. Therefore, re-establishing a healthy microbiota is a novel strategy for treating drug resistance organisms. Preliminary studies suggest that this is a viable approach. However, the extent of their success still needs to be examined. Herein, we will review work in this area and suggest where future studies can further investigate this method for dealing with the threat of antibiotic resistance.

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Fecal microbiota transplantation in the intestinal decolonization of carbapenamase-producing enterobacteriaceae

Cited by 4 publications

References 0 publications

Faecal microbiota replacement to eradicate antimicrobial resistant bacteria in the intestinal tract – a systematic review

Faecal microbiota replacement to eradicate antimicrobial resistant bacteria in the intestinal tract – a systematic review

Fecal microbiota transplantation for Carbapenem-Resistant Enterobacteriaceae: A systematic review

The Relationship Between the Microbiome and Antimicrobial Resistance

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