Fecal microbiota transplantation is safe and tolerable in patients with multiple sclerosis: A pilot randomized controlled trial

Al, Kait F.; Craven, Laura J; Gibbons, Shaeley; Parvathy, Seema Nair; Wing, Ana Christina; Graf, Chantelle; Parham, Kate A.; Kerfoot, Steven M.; Wilcox, Hannah; Burton, Jeremy P.; Kremenchutzky, Marcelo; Morrow, Sarah A.; Casserly, Courtney; Meddings, Jon; Sharma, Manas; Silverman, Michael

doi:10.1177/20552173221086662

Cited by 40 publications

(32 citation statements)

References 55 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…FMT has been assessed in a preliminary study of patients with MS [ 60 ]. Nine patients with MS were recruited and underwent FMTs monthly for up to six months.…”

Section: Multiple Sclerosis (Ms)mentioning

confidence: 99%

Gut Microbes and Neuropathology: Is There a Causal Nexus?

Dinan

2022

Pathogens

View full text Add to dashboard Cite

The gut microbiota is a virtual organ which produces a myriad of molecules that the brain and other organs require. Humans and microbes are in a symbiotic relationship, we feed the microbes, and in turn, they provide us with essential molecules. Bacteroidetes and Firmicutes phyla account for around 80% of the total human gut microbiota, and approximately 1000 species of bacteria have been identified in the human gut. In adults, the main factors influencing microbiota structure are diet, exercise, stress, disease and medications. In this narrative review, we explore the involvement of the gut microbiota in Parkinson’s disease, Alzheimer’s disease, multiple sclerosis and autism, as these are such high-prevalence disorders. We focus on preclinical studies that increase the understanding of disease pathophysiology. We examine the potential for targeting the gut microbiota in the development of novel therapies and the limitations of the currently published clinical studies. We conclude that while the field shows enormous promise, further large-scale studies are required if a causal link between these disorders and gut microbes is to be definitively established.

show abstract

“…FMT has been assessed in a preliminary study of patients with MS [ 60 ]. Nine patients with MS were recruited and underwent FMTs monthly for up to six months.…”

Section: Multiple Sclerosis (Ms)mentioning

confidence: 99%

Gut Microbes and Neuropathology: Is There a Causal Nexus?

Dinan

2022

Pathogens

View full text Add to dashboard Cite

show abstract

“…Given the association between the intestinal microbiota and manifestation of autoimmune neuroinflammation (1), microbiota manipulation might be a realistic mid-term approach to boost existing therapy options for MS patients. Potential strategies for microbiota modulation include administration of antibiotics or probiotics (33), dietary interventions (34,35) or fecal microbiota transplantation (36). However, such strategies are "untargeted", leading to broad-scale changes in the microbiota with potentially unpredictable outcomes.…”

Section: Discussionmentioning

confidence: 99%

Gut microbiome-based prediction of autoimmune neuroinflammation

Steimle

Neumann

Grant

et al. 2023

Preprint

View full text Add to dashboard Cite

Given the gut microbiota’s contribution to pathogenesis of autoimmune diseases, microbiota characteristics could potentially be used to predict disease susceptibility or progression. Although various gut commensals have been proposed as risk factors for autoimmune disease development, predictions based on microbiota composition alone remain unreliable. Here, we evaluated a common approach to identify a potential microbial risk factor from complex communities, followed by in-depth evaluation of its risk factor properties using an autoimmune neuroinflammation disease model in mice harboring several distinct, defined microbiota compositions. We found that the relative abundances of commensal taxa across distinct communities are poorly suited to assess the disease-mediating property of a given microbiota. Instead, the presence of certain microbial risk factors allowed us to determine the probability of severe disease, but failed to predict the individual disease course. We investigated multiple other microbiota-associated characteristics by applying 16S rRNA gene sequencing, metatranscriptomic and metabolomic approaches, as well as in-depth analysis of host immune responses and intestinal barrier integrity-associated readouts. By leveraging gnotobiotic mouse models harboring six defined compositions, we identified the IgA coating index ofBacteroides ovatusas a reliable individual disease risk predictor before disease onset, due to its ability to reflect autoimmunity-mediating properties of a given gut microbial network within a specific host. In summary, our data suggest that common taxonomic analysis approaches should be refined by taxonomic network analyses or combined with microbiota function-related readouts to reliably assess disease predisposition of a given host−microbiota combination.

show abstract

“…The authors reported no significant improvements in MRI, EDSS or plasma cytokine levels, although the lack of statistical power resulting from a small sample size may have obscured the outcomes of the study. Despite this, the authors were able to confirm that FMT was safe for their participants, and that the transplant resulted in the correction of the abnormally low α-diversity observed in the patients [ 80 ].…”

Section: Multiple Sclerosismentioning

confidence: 99%

The Role of Fecal Microbiota Transplantation in the Treatment of Neurodegenerative Diseases: A Review

Matheson

Holsinger

2023

IJMS

View full text Add to dashboard Cite

Neurodegenerative diseases are highly prevalent but poorly understood, and with few treatment options despite decades of intense research, attention has recently shifted toward other mediators of neurological disease that may present future targets for therapeutic research. One such mediator is the gut microbiome, which communicates with the brain through the gut–brain axis and has been implicated in various neurological disorders. Alterations in the gut microbiome have been associated with numerous neurological and other diseases, and restoration of the dysbiotic gut has been shown to improve disease conditions. One method of restoring a dysbiotic gut is via fecal microbiota transplantation (FMT), recolonizing the “diseased” gut with normal microbiome. Fecal microbiota transplantation is a treatment method traditionally used for Clostridium difficile infections, but it has recently been used in neurodegenerative disease research as a potential treatment method. This review aims to present a summary of neurodegenerative research that has used FMT, whether as a treatment or to investigate how the microbiome influences pathogenesis.

show abstract

Fecal microbiota transplantation is safe and tolerable in patients with multiple sclerosis: A pilot randomized controlled trial

Cited by 40 publications

References 55 publications

Gut Microbes and Neuropathology: Is There a Causal Nexus?

Gut Microbes and Neuropathology: Is There a Causal Nexus?

Gut microbiome-based prediction of autoimmune neuroinflammation

The Role of Fecal Microbiota Transplantation in the Treatment of Neurodegenerative Diseases: A Review

Contact Info

Product

Resources

About