Fecal Occult Blood: A Comparison of Chemical and Immunochemical Tests

Borges, Leonardo Lima; Mattar, Rejane; Silva, Joyce Matie Kinoshita da; Silva, Ana Luiza Werneck da; Carrilho, Flair José; Hashimoto, Cláudio L.

doi:10.1590/s0004-2803.201800000-22

Cited by 8 publications

(11 citation statements)

References 22 publications

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“…Diarrhea, stool consistency and presence of gross bleeding or occult blood in feces were also recorded and severity was scored from 0 to 4. Occulted blood in feces was determined as per the method prescribed by Borges et al 2018 ( Borges et al, 2018 ).…”

Section: Methodsmentioning

confidence: 99%

Defining the role of CFTR channel blocker and ClC-2 activator in DNBS induced gastrointestinal inflammation

Chidrawar

Alsuwayt

2021

Saudi Pharmaceutical Journal

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In the present study, we have investigated and/or compared the role of glibenclamide, G as cystic fibrosis transmembrane conductance regulator (CFTR) inhibitor, and lubiprostone, L as chloride channel-2 (ClC-2) activator in the 2,4-dinitrobenzene sulfonic acid (DNBS)-induced gastrointestinal inflammation. GI inflammation was induced by intrarectal administration of DNBS. Rats were randomly allocated in 5 groups as sham control, distilled water + DNBS, sulfasalazine (S) + DNBS, G + DNBS, and L + DNBS. All the groups were pre-treated successively for five days before the induction of colitis. One day before and the first four days after DNBS administration various parameters were studied. Later, blood chemistry, colon’s gross structure, histology, and the antioxidant load was examined. Pre-treatment with G significantly protected the change induced by DNBS concerning the change in body weight, food intake, diarrhea, occult blood in the feces, wet weight of the colon, and spleen. G because of its anti-inflammatory property down-regulated the neutrophil and WBC count and up-regulated the lymphocyte number. Moreover, G efficiently ameliorates the oxidative stress in the colon and declines the level of myeloperoxidase and malondialdehyde and up-regulated the level of superoxide dismutase and glutathione. Lubiprostone has not shown any promising effects, in fact, it causes an increase in diarrheal frequency. Our findings from this study represent that G has good potential to ameliorate GI inflammation induced by DNBS by its multiple actions including CFTR blockage and reducing the release of inflammatory markers from the MCs, anti-inflammatory and free radical scavenging property.

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Section: Methodsmentioning

confidence: 99%

Defining the role of CFTR channel blocker and ClC-2 activator in DNBS induced gastrointestinal inflammation

Chidrawar

Alsuwayt

2021

Saudi Pharmaceutical Journal

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“…Other tests, specific for CRC diagnosis are based on immunochemical tests to detect the presence of human hemoglobin and are sensitive for adenomas and advanced neoplasm diagnosis. Instead, the combination of immunochemical exams and multiple DNA markers has ensured progress in the diagnosis and discrimination among all these diseases and their progression stage [39] .…”

Section: Nucleic Acids Metabolites Proteins Analysis and Extracellula...mentioning

confidence: 99%

Biofluids manipulation methods for liquid biopsy in minimally-invasive assays

et al. 2022

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“…The immunohistochemical method is the most sensitive and specific method to detect human blood in faeces. It also has an additional advantage of being independent of food intake (13) . A positive faecal occult blood test has been shown to correlate positively with the presence of GI pathology associated with bleeding.…”

Section: Blood Lossmentioning

confidence: 99%

Chronic anaemia in children as a manifestation of gastrointestinal disorders

Wronecka¹,

Pac-Kożuchowska²,

Mroczkowska-Juchkiewicz³

et al. 2022

Pediatr Med Rodz

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Anaemia is a common problem encountered by paediatricians and general practitioners in the paediatric population. If left untreated, it can lead to serious health consequences, slower development and cognitive impairment. Therefore, it is extremely important to identify its cause and implement appropriate treatment. Since iron deficiency is the most common cause of anaemia, oral iron supplementation at appropriate doses should be used as a first step. However, anaemia may be secondary and often the only symptom of pathological processes in the body. It very often accompanies gastrointestinal diseases, which cause impaired absorption of hematopoietic elements, blood loss through the gastrointestinal tract and dysregulation of iron metabolism accompanying chronic diseases. Therefore, anaemia unresponsive to oral iron treatment should prompt diagnosis for gastrointestinal diseases most common in the paediatric population. Specialised investigations should target the suspected clinical entity, enabling its diagnosis. A correct diagnosis allows for optimal treatment of the underlying disease and, as a result, resolution of the pathology triggering anaemia. However, it takes a long time to regain normal intestinal mucosal function, therefore it is often necessary to additionally include intravenous iron infusions and, in selected cases, packed red blood cell transfusions to rapidly normalise red cell system parameters.

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Fecal Occult Blood: A Comparison of Chemical and Immunochemical Tests

Abstract: The immunochemical fecal occult blood tests showed greater sensitivity, specificity and predictive values in detecting colorectal bleeding. The immunochemical tests had superior indexes of agreement with colonoscopy compared to the toluidine test.

Cited by 8 publications

References 22 publications

Defining the role of CFTR channel blocker and ClC-2 activator in DNBS induced gastrointestinal inflammation

Defining the role of CFTR channel blocker and ClC-2 activator in DNBS induced gastrointestinal inflammation

Biofluids manipulation methods for liquid biopsy in minimally-invasive assays

Chronic anaemia in children as a manifestation of gastrointestinal disorders

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