Fecapentaenes and their precursors throughout the bowel — Results of an autopsy study

Schiffman, Mark; Bitterman, Pincas; Viciana, Ana L.; Schairer, C; Russell, Louise B.; Tassell, Roger L. Van; Wilkins, Tracy D.

doi:10.1016/0165-7992(88)90013-9

Cited by 13 publications

(2 citation statements)

References 12 publications

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“…bile acids were found to stimulate pro duction of the mutagen in vitro although they are not considered to be the precursor which has not, to date, been identified [60], It is not known whether the precursor is derived from diet, mammalian secretions or intestinal bacteria. FP is not universally present in human feces, but in positive sub jects has been detected in all regions of the large intestine [61].…”

Section: Microfloramentioning

confidence: 99%

Bacterial Enzymes: Their Role in the Formation of Mutagens and Carcinogens in the Intestine

Mallett¹,

Rowland²

1990

Dig Dis

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Section: Microfloramentioning

confidence: 99%

Bacterial Enzymes: Their Role in the Formation of Mutagens and Carcinogens in the Intestine

Mallett¹,

Rowland²

1990

Dig Dis

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“…Although the exact nature of these precursors remains to be determined, there are strong indications that they are phospholipids of type 3, already containing the pentaenol ether structure (12). In order to quantify the level of fecapentaenes and their precursors (total FP), several papers have described methods in which this level is analyzed after incubation of feces for 96 h at 37° (6,(13)(14)(15)(16)(17) in the presence of a fecapentaene-producing strain of bacteria.…”

mentioning

confidence: 99%

Quantitative HPLC Analysis of the Level of Fecapentaenes and Their Precursors in Human Feces by a Chemical Conversion Method

Kivits

Boer²,

Nugteren³

et al. 1990

J. Nat. Prod.

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A fast and reliable hplc method for the quantitative analysis of total fecapentaene-12 (FP-12 and its precursors) and total fecapentaene-14 (FP-14 and its precursors) in human feces is described. The analysis is based on the rapid chemical conversion of fecapentaenes and their precursors to more stable methoxytetraenols and the use of synthetic, not naturally occurring, fecapentaene-13 (FP-13) as an internal standard. The synthesis and physical properties of this internal standard are described. The convenience and reproducibility of the method were illustrated by applying the procedure to stool samples obtained from twelve individuals on 3 consecutive days. Levels of total FP's were in the range of 0.1-25.4 micrograms for total FP-12 and 0.1-8.5 micrograms for total FP-14 per g of wet feces. Appreciable fluctuations were observed between levels in samples from the same individual on different days. Reproducibility and recovery were shown to be good.

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Intestinal Bacteria and Disease

Gibson¹,

Macfarlane²

1994

Human Health

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Fecapentaenes and their precursors throughout the bowel — Results of an autopsy study

Cited by 13 publications

References 12 publications

Bacterial Enzymes: Their Role in the Formation of Mutagens and Carcinogens in the Intestine

Bacterial Enzymes: Their Role in the Formation of Mutagens and Carcinogens in the Intestine

Quantitative HPLC Analysis of the Level of Fecapentaenes and Their Precursors in Human Feces by a Chemical Conversion Method

Intestinal Bacteria and Disease

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