Fecundity and Quality of Life of Women Treated for Solid Childhood Tumors Between 1948 and 1992 in France

Thouvenin-Doulet, Sandrine; Berger, Claire; Casagranda, Léonie; Oberlin, Odile; Marec‐Bérard, Perrine; Pacquement, Hélène; Guibout, Catherine; Freyçon, Claire; Nguyen, Tan Dat; Bondiau, Pierre‐Yves; Laprie, A.; Berchery, Delphine; El‐Fayech, Chiraz; Vathaire, Florent de

doi:10.1089/jayao.2017.0126

Cited by 21 publications

(36 citation statements)

References 23 publications

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“…The effect in the study by Madanat et al (2008) failed to reach statistical significance: RR 0.65, 95% CI 0.43 to 1.00; I 2 = 81%; P = 0.05. The harmful effect was also confirmed after limiting the analysis to studies that included only patients under the age of 21 years: HR 0.86, 95% CI 0.77 to 0.97; I 2 = 0%; P = 0.02 (Chow et al, 2016;Armuand et al, 2017); and RaR 0.66, 95% CI 0.52 to 0.84; I 2 = 69%; P = 0.0006 (Thouvenin-Doulet et al, 2018); RR 0.50, 95% CI 0.33 to 0.76; I 2 = 71%; P = 0.001 (Madanat et al, 2008). In a sub-analysis, Chow et al (2016) calculated hazard ratios for pregnancy and live birth separately for patients treated with and without alkylating agents, showing a detrimental effect of the exposure to alkylating agents on both outcomes.…”

Section: Fertility After Bone Cancermentioning

confidence: 81%

“…Data on effect estimates (HR, RR, RaR, and OR) of pregnancy and live birth were extracted from the remaining 18 articles, all of which were published in peer-reviewed journals between 2004 and 2018 (Byrne et al, 2004;Hodgson et al, 2007;Syse et al, 2007;Madanat et al, 2008;Cvancarova et al, 2009;Reulen et al, 2009;Pivetta et al, 2011;Stensheim et al, 2011;van der Kaaij et al, 2012;Baxter et al, 2013;Dillon et al, 2013;Hartman et al, 2013;Brämswig et al, 2015;Chow et al, 2016;Armuand et al, 2017;Anderson et al, 2018a;2018b;Thouvenin-Doulet et al, 2018). Details of the characteristics of the included studies are presented in TABLE 1.…”

Section: Resultsmentioning

confidence: 99%

“…Results of studies reporting hazard ratios: HR 0.97, 95% CI 0.83 to 1.13; I 2 = 0%; P = 0.68 (Chow et al, 2016;Armuand et al, 2017) (FIGURE 2B) and relative risk deny any negative effect: RR 0.78, 95% CI 0.57 to 1.08 (Madanat et al, 2008). On the contrary, Thouvenin-Doulet et al (2018) reported a detrimental effect: RaR 0.67, 95% CI 0.57 to 0.79. All four studies included only patients under the age of 21 years (Madanat et al, 2008;Chow et al, 2016;Armuand et al, 2017;Thouvenin-Doulet et al, 2018).…”

Section: Fertility After Bone Cancermentioning

confidence: 96%

“…Pooling of results did not show a significant effect of this anamnestic Table 2 and data on the rate of women who achieved at least one pregnancy: HR 0.66, 95% CI 0.37 to 1.16; I 2 = 96%; P = 0.14. Differently, the meta-analysis of studies investigating the chances of live birth agree in showing a negative effect of a history of bone cancer: HR 0.86, 95% CI 0.77 to 0.97; I 2 = 0%; P = 0.02 (Chow et al, 2016;Armuand et al, 2017); and RaR 0.76, 95% CI 0.61 to 0.95; I 2 = 69%; P = 0.01 (Hartman et al, 2013;Thouvenin-Doulet et al, 2018) (FIGURE 2A). The effect in the study by Madanat et al (2008) failed to reach statistical significance: RR 0.65, 95% CI 0.43 to 1.00; I 2 = 81%; P = 0.05.…”

Section: Fertility After Bone Cancermentioning

confidence: 99%

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Fertility in female cancer survivors: a systematic review and meta-analysis

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Section: Fertility After Bone Cancermentioning

confidence: 81%

Section: Resultsmentioning

confidence: 99%

Section: Fertility After Bone Cancermentioning

confidence: 96%

Section: Fertility After Bone Cancermentioning

confidence: 99%

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Fertility in female cancer survivors: a systematic review and meta-analysis

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“…Problems with fertility and sexual health are strongly correlated with poor mental health. Equally, psychological factors are thought to be one reason why CYP cancer survivors develop problems with sexual function .…”

Section: Childhood Cancermentioning

confidence: 99%

Survival from cancer in young people: An overview of late effects focusing on reproductive health

Newton

Friend

Feltbower

et al. 2019

Acta Obstet Gynecol Scand

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This paper provides a summary of the areas of survival from childhood, teenage and young adult cancers and the significant late effects that can arise from treatment; with particular focus on the area of reproductive health and the impact on both fertility and pregnancy. To complete this review, Web of Science and MEDLINE were used. Search terms included: “"survival AND childhood OR teenage OR young adult cancer", "late effects", "childhood cancer", "teenage AND/OR young adult cancer", AND "fertility after cancer" OR "pregnancy AND cancer" OR "fertility preservation”. Additionally, the clinical expertise of the authors was drawn upon. Childhood cancer is a thankfully rare occurrence; however, the incidence is increasing. Survival rates remain high and this means that a growing population of childhood and young adult cancer survivors are reaching adulthood. For some of these adults, although cured of their cancer, they are now facing a future with lasting effects on their health from their treatments. These effects, commonly referred to as late effects, are defined as health problems related either directly to the underlying cancer or to its treatment and which occur months or years after treatment has finished. Reproductive health is an important consideration for these patients, and although many will be able to conceive naturally, some will exhibit impaired fertility after their treatments. This can include difficulties at all points along the path from conception to delivery of a live, healthy offspring. High‐quality, large‐population evidence is sparse in many areas relating to fertility risk from treatment and the maternal and fetal health of childhood cancer survivors. Yet given the potential for complications, the authors advocate consideration of fertility at the time of diagnosis and before potentially gonadotoxic treatment.

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Quality of life of adolescent and adult survivors of childhood cancer in Europe—A systematic review

Larsen

Amidi

Ghith

et al. 2023

Intl Journal of Cancer

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Advances in diagnostics and treatment of childhood cancer during the past few decades have substantially increased survival, resulting in a growing population of survivors of childhood cancer. Somatic and mental late effects of the cancer and the treatment may impact the quality of life (QoL). Previous reviews of QoL in survivors of childhood cancer have shown contradictory findings across studies and the majority of studies included have been based on data from North America and may not be directly comparable to a European setting. The aim of our study was to critically evaluate and summarise the latest evidence on the QoL of childhood cancer survivors in Europe and to identify survivors at particular risk. The eligible studies were published between 2008 and 2022, conducted in Europe and included participants who had survived at least 5 years after diagnosis of a childhood cancer. The main outcome of interest was QoL of survivors which was measured with validated qualitative and quantitative QoL questionnaires. A systematic literature search conducted in PubMed, EMBASE, PsycINFO and CINALH resulted in inclusion of 36 articles with a total of 14 342 survivors of childhood cancer. The majority of included studies found that childhood cancer survivors reported poorer QoL than comparisons. Female gender, treatment with haematopoietic stem cell transplantation and a brain tumour diagnosis were associated with lower QoL. With a growing population of childhood cancer survivors with many years ahead of them, targeted interventions and optimal follow‐up care are important to improve the QoL of survivors.

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Fecundity and Quality of Life of Women Treated for Solid Childhood Tumors Between 1948 and 1992 in France

Cited by 21 publications

References 23 publications

Fertility in female cancer survivors: a systematic review and meta-analysis

Fertility in female cancer survivors: a systematic review and meta-analysis

Survival from cancer in young people: An overview of late effects focusing on reproductive health

Quality of life of adolescent and adult survivors of childhood cancer in Europe—A systematic review

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