Fecundity disorders in older women: declines in follicular development and endometrial receptivity

Wang, Li; Lv, Shulan; Mao, Wenjun; Bai, E; Yang, Xiaofeng

doi:10.21203/rs.2.19865/v3

Cited by 1 publication

(2 citation statements)

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“…[8,9] Decreased ovarian function not only affects the quantity and quality of oocytes and embryos, [10] but it also may impair endometrial receptivity. [11] Decreased ovarian reserve and endometrial injury caused by abortion and endometritis after delivery may also explain reduced endometrial receptivity. Some studies have reported that the pregnancy rate and LBR of patients over 40 years old with frozen embryo transfer have increased significantly.…”

Section: Discussionmentioning

confidence: 99%

“…The main reasons for the age-related decrease in oocyte and embryo quantity and quality include increased chromosomal abnormalities and apoptosis in oocytes, decreased mitochondrial number impacting function, and insufficient energy supply eventually leading to reduced oocyte number and viability [8,9] . Decreased ovarian function not only affects the quantity and quality of oocytes and embryos, [10] but it also may impair endometrial receptivity [11] . Decreased ovarian reserve and endometrial injury caused by abortion and endometritis after delivery may also explain reduced endometrial receptivity.…”

Section: Discussionmentioning

confidence: 99%

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Clinical outcomes after elective double-embryo transfer in frozen cycles for women of advanced maternal age

et al. 2022

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We aimed to determine the clinical outcome of double cleavage-stage embryo transfers in frozen-thawed embryo transfer cycles for older women.This study analyzed a total of 8189 cleavage-stage frozen-thawed embryo transfer cycles between January 2013 and December 2017 at Sir Run Run Shaw Hospital. All cycles were sorted into 3 groups based on patient age: 35 years (Group A), 36 to 37 years (Group B), and ≥38 years (Group C). The clinical pregnancy rate (CPR), implantation rate (IR), live birth rate (LBR), miscarriage rate, multiple pregnancy rate (MPR), preterm birth rate, and low-birth-weight rate were compared between the 3 groups.Significant differences in CPR, IR, LBR, MPR, and premature birth rate were found among the 3 groups. The CPR, IR, LBR, and MPR in Group A were higher than those in Group C. Transfers of 2 high-quality embryos resulted in significant differences in CPR, IR, LBR, MPR, and neonatal weight among the 3 groups, but no differences in premature birth and abortion rates were observed. Transfers with 1 high-quality and 1 fair-quality embryo resulted in significant differences in CPR, IR, and LBR among the 3 groups. Comparison of transfers of 2 high-quality embryos with 1 high-quality and 1 fair-quality embryo showed that the CPR and LBR were significantly lower for the latter in Groups A and C, but Group B had no salient changes.Higher IR and LBR and lower MPR may be achieved by selection of optimal embryo types for patients of different ages. Two highquality embryos need to be transferred in women older than 38 years. For women aged 36 to 37 years, 1 high-quality embryo or 1 high-quality plus 1 fair-quality embryo should be singled out for transfer. For women younger than 35 years, a single high-quality embryo should be selected for transfer. Abbreviations: BMI = body mass index, CPR = clinical pregnancy rate, FET = frozen-thawed embryo transfers, HCG = human chorionic gonadotropin, HMG = human menopausal gonadotropin, ICSI = intracytoplasmic sperm injection, IR = implantation rate, IVF = in vitro fertilization, LBR = live birth rate, MPR = multiple pregnancy rate.

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