Fed-Batch Fermentation with Integrated Reactive Extraction for L-Phenylalanine Production

Gerigk, M.; Maass, Danielle; A, Kreutzer; Bongaerts, Johannes; Schmidt, Klaus; Sprenger, Georg A.; Wubbolts, Marcel; Wandrey, Christian

doi:10.1016/s1474-6670(17)34217-9

Cited by 1 publication

(1 citation statement)

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“…The recovery of amino acids by reactive extraction has been described by numerous authors. Bart et al and Pursell et al investigated the extraction of phenylalanine with the amine‐based cation exchanger Aliquat 336, while Rüffer et al , Rüffer , and Takors et al extracted phenylalanine in situ from a fermentation broth using the anion exchanger di‐(2‐ethylhexyl)phosphoric acid (D2EHPA) dissolved in kerosin. Oniscu et al , Cascaval et al , , and Kloetzer et al investigated the extraction of acidic, neutral, and basic amino acids as a function of the pH by means of the solvent system D2EHPA + n ‐butyl acetate.…”

Section: Introductionmentioning

confidence: 99%

Efficient Concentration of an Amino Acid Using Reactive Extraction Coupled with Bipolar Electrodialysis

Buchbender

Wiese

2018

Chem Eng & Technol

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One intention of the PRODIAS (processing diluted aqueous systems) project is to develop and establish a toolbox of innovative and tailored separation technologies applicable to design energy‐efficient water removal and product recovery techniques. Within this project, the recovery of γ‐aminobutyric acid (GABA) was investigated. Using both synthetic as well as fermented solutions, reactive extraction of GABA with the solvent di‐(2‐ethylhexyl)phosphoric acid + isododecane was performed. For back extraction, different mineral acids were examined. Multistage countercurrent reactive extraction using pH adjustments along the stages to increase extraction efficiency as well as back extraction were then run on pilot‐plant scale with fermented GABA solutions. The resulting GABA salt from back extraction was finally split by means of bipolar electrodialysis.

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