Since the mid-1980s, exercise has been tested as an intervention strategy to help cancer patients prepare for treatments, cope with treatments, and recover after treatments. The field of physical activity and cancer survivorship-"exercise oncology"-began with a trickle of studies published in the mid-1980s that has turned into a torrent of studies published since the first decade of the 2000s. The literature now contains hundreds of studies about the effects of exercise in people who have been diagnosed with cancer (that is, cancer survivors), which have spawned dozens of systematic reviews, several international guidelines, and calls for the integration of exercise programs into clinical and community cancer care.In this issue of Current Oncology, Roanne Segal (a pioneer in the field of exercise oncology) and colleagues report the first Canadian exercise guidelines for cancer survivors 1 . The authors followed a rigorous process in developing their guidelines, including appraisal of three existing guidelines, eighteen systematic reviews, and twenty-nine recent randomized controlled trials, and acceptance of comments from independent reviews by several expert panels. The authors correctly conclude that there is sufficient (overwhelming?) evidence that exercise is safe and feasible and that it improves health-related fitness (aerobic fitness, muscular strength) and quality of life for survivors both during and after cancer treatments. Although not explicitly reviewed by the authors, there is also good evidence that exercise improves several cancer-specific symptoms such as fatigue 2 , sleep dysfunction 3 , and depression 4 .Based on the evidence, the authors recommend that cancer survivors perform at least 150 minutes of aerobic exercise and 2-3 days of strength exercise weeklyrecommendations that are consistent with other general and cancer-specific exercise guidelines. The authors note that their recommendations are intended for policymakers, clinicians, and institutions treating cancer patients in Ontario (and presumably throughout Canada) with the goal of changing clinical practice. The guideline is an important first step in the quest to have exercise programs integrated into cancer care in Canada. However, is evidence of benefit to fitness and quality of life enough to change clinical oncology practice and to make exercise programs an essential component of cancer care? Certainly, the evidence for fitness and quality-of-life benefits would seem sufficient for clinicians to at least recommend exercise to their patients and perhaps even to refer them to one of the growing number of community-based exercise programs for cancer survivors [5][6][7][8][9] . But what would it take for cancer centres themselves to integrate high-quality exercise programs into clinical cancer care? The likely answer to that question is evidence of a direct benefit of exercise for cancer outcomes-that is, recurrence, progression, and survival. The authors themselves noted comments from the independent Expert Panel that highlighted th...