Feed restriction in cyclic gilts:
gonadotrophin-independent effects on follicular growth

Quesnel, Hélène; Pasquier, A.; Mounier, Anne-Marie; Prunier, Armelle

doi:10.1051/rnd:2000108

Cited by 17 publications

(21 citation statements)

References 26 publications

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“…Most of these factors influence the hypothalamic-pituitary-gonadal (HPG) axis (for review see [8]). Potential sites of action of nutrition on ovarian function include systemic effects at the hypothalamic level via GnRH synthesis and release; the anterior pituitary through control of synthesis and release of FSH, LH, and growth hormone (GH); at the ovarian level through regulation of follicle growth [44] and steroid synthesis [45]. There are also possible local sites of action via effects on the cascade of growth factors and their binding proteins within the ovary [42, 45].…”

Section: Sites Implicated In the Control Of Energy Balance Linked mentioning

confidence: 99%

Integrative Control of Energy Balance and Reproduction in Females

García-García

2012

ISRN Veterinary Science

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There is a strong association between nutrition and reproduction. Chronic dietary energy deficits as well as energy surpluses can impair reproductive capacity. Metabolic status impacts reproductive function at systemic level, modulating the hypothalamic GnRH neuronal network and/or the pituitary gonadotropin secretion through several hormones and neuropeptides, and at the ovarian level, acting through the regulation of follicle growth and steroidogenesis by means of the growth hormone-IGF-insulin system and local ovarian mediators. In the past years, several hormones and neuropeptides have been emerging as important mediators between energy balance and reproduction. The present review goes over the main sites implicated in the control of energy balance linked to reproductive success and summarizes the most important metabolic and neuroendocrine signals that participate in reproductive events with special emphasis on the role of recently discovered neuroendocrine peptides. Also, a little overview about the effects of maternal nutrition, affecting offspring reproduction, has been presented.

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Section: Sites Implicated In the Control Of Energy Balance Linked mentioning

confidence: 99%

Integrative Control of Energy Balance and Reproduction in Females

García-García

2012

ISRN Veterinary Science

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“…A negative energy balance during first lactation affects subsequent follicular development (Quesnel et al, 2000), ovulation rate (Hazeleger et al, 2005), oocyte development (Zak et al, 1997b), and embryo develop-ment (Algriany et al, 2004), and ultimately leads to embryo mortality (Almeida et al, 2000). As a result, primiparous sows commonly have increased intervals from weaning to estrus, reduced farrowing rates, and reduced litter sizes (Morrow et al, 1989).…”

Section: Introductionmentioning

confidence: 99%

The effect of different postweaning altrenogest treatments of primiparous sows on follicular development, pregnancy rates, and litter sizes1

Leeuwen

Williams

Martens³

et al. 2011

Journal of Animal Science

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This study investigated follicular development during and after postweaning altrenogest treatment of primiparous sows in relation to subsequent reproductive performance. Primiparous sows (n = 259) were randomly assigned at weaning (d 0) to 1 of 4 groups: control (no altrenogest, n = 71), RU4 (20 mg of altrenogest from d -1 to 2, n = 62), RU8 (20 mg of altrenogest from d -1 to 6, n = 65), or RU15 (20 mg of altrenogest from d -1 to 13, n = 61). Average follicular size (measured by ultrasound) increased during altrenogest treatment and resulted in larger follicles at the start of the follicular phase for RU4, RU8, and RU15 compared with controls (5.3 ± 0.9, 5.5 ± 1.3, 5.1 ± 1.2, and 3.4 ± 0.6 mm, respectively; P < 0.0001). Farrowing rate was greater in RU15 (95%) than in RU8 (76%; P = 0.04). The RU15 group also had more piglets (2 to 3 more piglets total born and born alive; P < 0.05) than the other treatment groups. Follicular development at weaning clearly affected reproductive performance. At weaning, average follicular size: small (<3.5 mm), medium (3.5 to 4.5 mm), or large (≥ 4.5 mm), was associated with farrowing rates of 86, 78, and 48%, respectively (P < 0.001). Sows with large follicles at weaning had low farrowing rates (71%) in RU4, very low farrowing rates (22%) in RU8, but normal farrowing rates in RU15 (83%). In conclusion, this study showed that 15 d of postweaning altrenogest treatment of primiparous sows may allow follicle turnover in sows that had large follicles at weaning and that this was associated with an improved reproductive performance. It also showed that shorter treatment with altrenogest (4 or 8 d) is beneficial for sows with small follicles at weaning, but is not recommendable for sows with large follicles at weaning.

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“…Feed-restriction, which significantly decreased ovarian weight but did not alter the number of medium and large follicles (≥ 2mm, [28]), had no significant influence on GH and IGF-I binding to ovarian membranes. However, cell-specific alterations cannot be excluded since GH and IGF-I binding sites are widely distributed within porcine ovaries [26].…”

Section: Discussionmentioning

confidence: 87%

“…In this context, six gilts in each feeding group were treated with an antagonist of GnRH, Antarelix, from day 3 to day 12. A full description was reported previously [28].…”

Section: Animals and Experimental Designmentioning

confidence: 99%

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GH and IGF-I binding sites in adipose tissue, liver, skeletal muscle and ovaries of feed-restricted gilts

2000

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-The influence of feed restriction on GH and IGF-I binding was examined in the cyclic gilt. IGF-I, IGFBPs, insulin and leptin levels in plasma were also measured. Twenty-four gilts whose oestrous cycle was synchronised were used. From day 3 to day 12, (with day 0 being the first day of oestrus) feed allowance was 240% and 80% of the energy requirements for maintenance for well-fed (H) and restricted gilts (L) respectively. Six gilts in each group were treated with an antagonist of GnRH but the treatment had no effect on any reported measurements. Blood and tissue samples were collected on days 12 and 13 respectively. L gilts lost live weight whereas H gilts gained weight. Plasma IGF-I, insulin and leptin concentrations were lower in L than in H gilts whereas plasma IGFBP levels were not affected by feed restriction. The specific binding of 125 I-bGH to adipose tissue, liver, skeletal muscle and ovary membranes did not differ significantly between H and L gilts. Specific binding of 125 I-IGF-I to hepatic membranes was higher in L than in H gilts whereas it did not differ between the two groups in the other tissue membranes.

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Feed restriction in cyclic gilts: gonadotrophin-independent effects on follicular growth

Cited by 17 publications

References 26 publications

Integrative Control of Energy Balance and Reproduction in Females

Integrative Control of Energy Balance and Reproduction in Females

The effect of different postweaning altrenogest treatments of primiparous sows on follicular development, pregnancy rates, and litter sizes1

GH and IGF-I binding sites in adipose tissue, liver, skeletal muscle and ovaries of feed-restricted gilts

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