Purpose-To evaluate the impact of a prescriber focused individual educational and auditfeedback intervention undertaken by the Nova Scotia Prescription Monitoring Program (NSPMP) in March/April 2007 to reduce meperidine use.Method-The NSPMP records all prescriptions for controlled substances dispensed in community pharmacies in Nova Scotia, Canada. Oral meperidine use from 1 July 2005 to 31 December 2009 was examined using NSPMP data. Monthly totals for the following were obtained: number of individual patients who filled at least one meperidine prescription, number of prescriptions, and number of tablets dispensed. Data were analyzed graphically to observe overall trends. The intervention effect was estimated on the logarithmic scale with autocorrelations over time modeled by an integrated autoregressive moving average model for each outcome measure.
Results-An
CIHR Author ManuscriptCIHR Author Manuscript CIHR Author Manuscript confidence interval [CI] = 5%-18%), prescriptions by 10% (p <0.001; 95%CI = 3%-17%), and tablets by 13.5% (p <0.001, 95%CI = 6%-29%) in the post-intervention period.Conclusion-Given the risks associated with meperidine, determining that this intervention successfully reduced meperidine use is encouraging. This study highlights the potential for using population data such as the NSPMP to evaluate the effectiveness of population-level interventions to improve medication use, including professional, organizational, financial, and regulatory initiatives.