Feedback Control of a Recombinant Fed-Batch Fermentation Using On-Line HPLC Measurements

Saucedo, Victor M.; Valentinotti, Sergio; Karim, M. Nazmul; Collins, Haley

doi:10.1016/s1474-6670(17)45596-0

Cited by 2 publications

(3 citation statements)

References 10 publications

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“…Centrifugation rather than filtration to improve reliability Turner et al (1993Turner et al ( , 1994 Rhone-Poulenc Saucedo et al (1995) Ethanol…”

Section: E Colimentioning

confidence: 99%

“…Required broth stream filtration Kobayashi et al (1987) Anchorage-dependent mammalian cells Stable and reproducible only up to 7 days Male et al (1997) Glucose Recominant E. coli Maximized biomass for protein yields Garn et al (1989) Ciba-Geigy Glucose, organic acids E. coli Centrifugation rather than filtration to improve reliability Turner et al (1993Turner et al ( , 1994 Rhone-Poulenc Saucedo et al (1995) Ethanol…”

Section: E Colimentioning

confidence: 99%

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Bioprocess monitoring and computer control: Key roots of the current PAT initiative

Junker

Wang

2006

Biotech & Bioengineering

115

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This review article has been written for the journal, Biotechnology and Bioengineering, to commemorate the 70th birthday of Daniel I.C. Wang, who served as doctoral thesis advisor to each of the co-authors, but a decade apart. Key roots of the current PAT initiative in bioprocess monitoring and control are described, focusing on the impact of Danny Wang's research as a professor at MIT. The history of computer control and monitoring in biochemical processing has been used to identify the areas that have already benefited and those that are most likely to benefit in the future from PAT applications. Past applications have included the use of indirect estimation methods for cell density, expansion of on-line/at-line and on-line/in situ measurement techniques, and development of models and expert systems for control and optimization. Future applications are likely to encompass additional novel measurement technologies, measurements for multi-scale and disposable bioreactors, real time batch release, and more efficient data utilization to achieve process validation and continuous improvement goals. Dan Wang's substantial contributions in this arena have been one key factor in steering the PAT initiative towards realistic and attainable industrial applications.

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“…Centrifugation rather than filtration to improve reliability Turner et al (1993Turner et al ( , 1994 Rhone-Poulenc Saucedo et al (1995) Ethanol…”

Section: E Colimentioning

confidence: 99%

Section: E Colimentioning

confidence: 99%

Bioprocess monitoring and computer control: Key roots of the current PAT initiative

Junker

Wang

2006

Biotech & Bioengineering

115

View full text Add to dashboard Cite

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“…The integration of analytical equipment into the fermentation processes has also been attempted. These include the integration of the equipment such as on-line HPLC (High Performance Liquid Chromatography) (Saucedo et al, 1995) and FIA (Flow Injection Analysis) (Hitzmann et al, 1995) into the processes. Although the time delay of measurement is reduced by the on-line integrated equipment, it is still not entirely eliminated.…”

mentioning

confidence: 99%

Modelling and control of fed-batch fermentation processes: towards improved quality and productivity

Zhang

Vanichsriratana

Tang

et al. 1997

Transactions of the Institute of Measurement and Control

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This paper describes research into modelling, estimation and control of fed batch fermentation and an application to a large fermentation plant producing secondary metabolites. The problems are examined in a general sense from the viewpoints of both biological science and control engineering. Very extensive modelling and estimation work has been carried out. Only the most significant outcomes are reported here but references to the detailed research are given. Some of the research has resulted in the development of a novel advanced supervisory system -the Intelligent Process Management System (IPMS). Experience of applying the IPMS to a large-scale production process is described. The software has been designed on a modular basis and although implemented initially at one production plant, the approach is generic and fundamentally plantindependent so that further application to a range of other plants is envisaged.

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Feedback Control of a Recombinant Fed-Batch Fermentation Using On-Line HPLC Measurements

Cited by 2 publications

References 10 publications

Bioprocess monitoring and computer control: Key roots of the current PAT initiative

Bioprocess monitoring and computer control: Key roots of the current PAT initiative

Modelling and control of fed-batch fermentation processes: towards improved quality and productivity

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