Feedback Control of ACTH Secretion by Cortisol

Gann, Donald S.; Cryer, George L.

doi:10.1159/000394214

Cited by 17 publications

(5 citation statements)

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“…We have previously found that the total ACTH re- are similar to the levels achieved in dogs during acute hypoglycemia (100-700 pg/ml ACTH, 3-11 g/i100 ml corticosteroids) (4), hemorrhage (20-80 pg/ml, 2-6 Mg/100 ml) (14) or hypoxia (100-400 pg/ml, [2][3][4][5][6][7][8][9][10][11][12] gg/100 ml) (15), or after endotoxin injection (1,500 pg/ml, 12 g/1i00 ml) (unpublished observation), or during hypoglycemia (100-300 pg/ml, 20 g/i100 ml) (16) in man. The suppression of the adrenocortical system response to hypoglycemia probably resulted from the increase in plasma corticosteroid concentrations that occurred during the ACTH infusion.…”

Section: Resultsmentioning

confidence: 85%

Feedback inhibition of adrenocorticotropic hormone by physiological increases in plasma corticosteroids in conscious dogs.

Keller‐Wood¹,

Shinsako²,

Dallman³

1983

J. Clin. Invest.

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A B S T R A C T We have tested the effect of physiological increases in plasma corticosteroids in conscious dogs on the levels of basal and hypoglycemia-stimulated adrenocorticotropic hormone (ACTH) 2 h later. Increases in plasma corticosteroids, produced by infusion of a-1-24 ACTH or corticosteroids for 40 min, suppressed basal and stimulated ACTH levels. The magnitude of inhibition produced by an increase in plasma corticosteroids induced by the infusion of ACTH was equivalent to the inhibition produced by the same increase in plasma corticosteroids induced by corticosteroid infusion. The infusions did not affect basal plasma glucose concentrations or the decrease in plasma glucose concentrations after administration of 0.1 U insulin/kg. Basal ACTH concentration was less sensitive than hypoglycemia-stimulated ACTH concentration to corticosteroid-induced suppression. Basal and stimulated secretion were significantly inhibited in all dogs after approximately half-maximal increases in plasma corticosteroids; maximum inhibition occurred after maximal increases in plasma corticosteroids. Therefore, physiological increments in plasma corticosteroids, similar to those produced by acute stress, are effective suppressors of subsequent stressinduced ACTH secretion.

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Section: Resultsmentioning

confidence: 85%

Feedback inhibition of adrenocorticotropic hormone by physiological increases in plasma corticosteroids in conscious dogs.

Keller‐Wood¹,

Shinsako²,

Dallman³

1983

J. Clin. Invest.

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“…In a recent study, we also found that depression of BK-induced PE by intrathecal nicotine largely depends on the HPA axis (Miao et al 1996 b). Since the activity in the subdiaphragmatic vagal afferents tonically inhibits the HPA axis (Gann & Cryer, 1973;Gonzalez-Fernandez & (Coupland et al 1989;Precht & Powley, 1990 (Carr & W\tilhelm, 1964). After a baseline perfusion period of 15 min with vehicle (normal saline), plasma extravasation into the knee joint was stimulated by adding bradykinin (BK, 160 ng ml-', i.e.…”

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confidence: 99%

Vagal branches involved in inhibition of bradykinin‐induced synovial plasma extravasation by intrathecal nicotine and noxious stimulation in the rat.

Miao

Jänig

Levine

1997

The Journal of Physiology

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“…This contrast is also illustrated by the results of other experiments in both adult and fetal animals. In adult dogs vagotomy reduces the magnitude of the AVP and ACTH responses to haemorrhage (Share, 1967; Gann & Cryer, 1973), while in fetal sheep vagotomy does not (Wood et al 1989). Therefore, it is likely that the atrial receptors become active or otherwise important sometime near the time of or after birth.…”

Section: Discussionmentioning

confidence: 99%

The ovine fetal endocrine reflex responses to haemorrhage are not mediated by cardiac nerves

Wood

2002

The Journal of Physiology

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This study was designed to test the hypothesis that cardiac receptors tonically inhibit the secretion of renin, arginine vasopressin (AVP) and adrenocorticotropic hormone (ACTH) in late‐gestation fetal sheep. Eight chronically catheterised fetal sheep between 122 and 134 days gestation were subjected to injection or infusion of saline or 4 % procaine into the pericardial space. Fetal blood pressure and heart rate were monitored and fetal blood samples were drawn to measure the response to these injections. Injection of procaine into the pericardial space effectively blocked cardiac nerves, as evidenced by a reduction in the variability of fetal heart rate and by the blockade of reflex reductions in fetal heart rate after intravenous injection of phenylephrine (an α‐adrenergic agonist which raises blood pressure). Injection of saline had no discernable effects on any of the measured variables. A single injection of procaine, followed by a slow infusion, produced a transient blockade of cardiac nerves. Multiple injections of procaine produced a sustained blockade of cardiac nerves and a sustained rise in fetal plasma renin activity and ACTH. In none of the experiments did procaine significantly alter fetal plasma AVP concentrations. In 11 fetuses between 121 and 134 days gestation, we combined the cardiac nerve blockade with slow haemorrhage to test the cardiac nerves as mediators of the endocrine response to haemorrhage in utero. Cardiac nerve blockade exaggerated the fetal blood gas response to haemorrhage somewhat but did not significantly alter the magnitude of the ACTH, AVP, or plasma renin activity response to haemorrhage. We conclude that cardiac nerves in the late‐gestation fetal sheep have minor influences on plasma renin activity and ACTH in normovolaemic fetuses, but that changes in cardiac nerve activity do not mediate the endocrine responsiveness to haemorrhage.

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Feedback Control of ACTH Secretion by Cortisol

Cited by 17 publications

References 0 publications

Feedback inhibition of adrenocorticotropic hormone by physiological increases in plasma corticosteroids in conscious dogs.

Feedback inhibition of adrenocorticotropic hormone by physiological increases in plasma corticosteroids in conscious dogs.

Vagal branches involved in inhibition of bradykinin‐induced synovial plasma extravasation by intrathecal nicotine and noxious stimulation in the rat.

The ovine fetal endocrine reflex responses to haemorrhage are not mediated by cardiac nerves

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