2018
DOI: 10.3934/mbe.2018030
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Feedback control of an HBV model based on ensemble kalman filter and differential evolution

Abstract: In this paper, we derive efficient drug treatment strategies for hepatitis B virus (HBV) infection by formulating a feedback control problem. We introduce and analyze a dynamic mathematical model that describes the HBV infection during antiviral therapy. We determine the reproduction number and then conduct a qualitative analysis of the model using the number. A control problem is considered to minimize the viral load with consideration for the treatment costs. In order to reflect the status of patients at bot… Show more

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Cited by 10 publications
(3 citation statements)
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“…The use of fuzzy controllers and various optimization algorithms for disease control are also applied in the study by Sheikhan and Ghoreishi. 32 In the study by Jang, 33 feedback control based on Kalman filter and differential evolution is reported. Lyapunov-based method has been utilized in the study by Ding and Wang.…”
Section: Introductionmentioning
confidence: 99%
“…The use of fuzzy controllers and various optimization algorithms for disease control are also applied in the study by Sheikhan and Ghoreishi. 32 In the study by Jang, 33 feedback control based on Kalman filter and differential evolution is reported. Lyapunov-based method has been utilized in the study by Ding and Wang.…”
Section: Introductionmentioning
confidence: 99%
“…As a variant of the Kalman filter, the Ensemble Kalman filter (EnKF) [3] is introduced to deal with the nonlinear state-space model, assuming that all probability distributions are Gaussian. There have been numerous applications involving EnKF, such as physical models of the atmosphere, oceans in geophysical systems [4,5], and biological science [6].…”
Section: Introductionmentioning
confidence: 99%
“…The Ensemble Kalman Filter (EnKF) is a Bayesian filtering algorithm used to estimate unknown states and parameters of nonlinear systems by combining model predictions with available system observations [1][2][3]. While these algorithms are commonly used for data assimilation in applications to weather prediction [4][5][6] and guidance, navigation, and control [7][8][9], ensemble Kalman-type filters have recently been utilized for parameter estimation and forecast prediction in a variety of epidemiological studies [10][11][12][13][14][15][16].…”
Section: Introductionmentioning
confidence: 99%