Feedback control system for large scale 2D digital microfluidic platforms

Li, Chunqiao; Zhang, Kaidi; Wang, Xubo; Zhang, Jian; Liu, Hong

doi:10.1016/j.snb.2017.09.071

Cited by 27 publications

(10 citation statements)

References 18 publications

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“…89 In electrowetting-on-dielectric (EWOD) digital microfluidic systems, algorithmic feedback has been implemented to standardize upstream droplet generation and pathfinding on large-scale devices. 90,91 For on-the-fly adaptation such as error correction from channel blockage, flexible microfluidics have been develop that change channel dimensions in response to a bias voltage change, clearing clogs in the system. 92 Optimization of microfluidic functions have also been implemented with proportional-integral-derivative (PID) control and design of experiments (DoE) methods.…”

Section: Non-machine Learning Based Methodsmentioning

confidence: 99%

Machine learning for microfluidic design and control

et al. 2022

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Section: Non-machine Learning Based Methodsmentioning

confidence: 99%

Machine learning for microfluidic design and control

et al. 2022

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“…Jie Gao et al [ 31 ] utilized the photolithography fabrication technique in a cleanroom to produce the bottom electrode layers, which can control droplets as small as 0.7 µL. Chunqiao Li et al [ 32 ] showed that plate-through-hole print circuit board (PTH-PCB) fabrication, which is a technique for fabricating multiple-layer printed circuit boards, could produce EWOD electrodes capable of controlling droplets with sizes as small as 1 µL. Vandana Jain et al [ 33 ] created electrode layers on a single-layer printed circuit board that could control droplets as small as 4.5 µL.…”

Section: Electrowetting-on-dielectric (Ewod) Platform Fabricationmentioning

confidence: 99%

“… Possible droplet volume according to fabrication techniques. ( a ) R. Malk et al, (2011) [ 30 ]; ( b ) Jie Gao et al, (2015) [ 31 ]; ( c ) Chunqiao Li et al, (2018) [ 32 ]; ( d ) Vandana Jain et al, (2015) [ 33 ]; ( e ) M. Yafia et al, (2014) [ 3 ]. …”

Section: Figurementioning

confidence: 99%

Sensitivity Validation of EWOD Devices for Diagnosis of Early Mortality Syndrome (EMS) in Shrimp Using Colorimetric LAMP–XO Technique

Sukthang

Kampeera

Sriprachuabwong

et al. 2021

Sensors

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Electrowetting-on-dielectric (EWOD) is a microfluidic technology used for manipulating liquid droplets at microliter to nanoliter scale. EWOD has the ability to facilitate the accurate manipulation of liquid droplets, i.e., transporting, dispensing, splitting, and mixing. In this work, EWOD fabrication with suitable and affordable materials is proposed for creating EWOD lab-on-a-chip platforms. The EWOD platforms are applied for the diagnosis of early mortality syndrome (EMS) in shrimp by utilizing the colorimetric loop-mediated isothermal amplification method with pH-sensitive xylenol orange (LAMP–XO) diagnosis technique. The qualitative sensitivity is observed by comparing the limit of detection (LOD) while performing the LAMP–XO diagnosis test on the proposed lab-on-a-chip EWOD platform, alongside standard LAMP laboratory tests. The comparison results confirm the reliability of EMS diagnosis on the EWOD platform with qualitative sensitivity for detecting the EMS DNA plasmid concentration at 102 copies in a similar manner to the common LAMP diagnosis tests.

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“…In contrast, digital microfluidics (DMF) [16][17][18] offers highlevel controllability of many individual μL/nL droplets via the electrowetting-on-dielectric effect, which bypasses the usage This journal is © The Royal Society of Chemistry 2022 of extra pumps and valves. It presents additional flexibility for MCA by integrating thermostats 14,19,20 beneath the dielectric for exploring the SNP melting temperatures (T m ).…”

Section: Introductionmentioning

confidence: 99%