Feedback loop process to control acoustic cavitation

Sabraoui, Abbas; Inserra, Claude; Gilles, B.; Béra, Jean‐Christophe; Mestas, Jean‐Louis

doi:10.1016/j.ultsonch.2010.07.011

Cited by 30 publications

(11 citation statements)

References 24 publications

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“…In addition, because the inertial cavitation dose saturation curve follows the microbubble cavitation‐induced bioeffect level, the inertial cavitation dose may provide implicit dosimetry of the bioeffects over a wide range of US parameters 22 . Such findings allowed the proposal of broadband noise measurements based on implicit dose metrics to regulate the inertial cavitation level through a real‐time feedback loop 32 . However, from a practical application point, it is complicated to use the inertial cavitation dose to visualize the sample parts exposed to insufficient inertial cavitation levels 9 .…”

Section: Discussionmentioning

confidence: 99%

Microbubble Sonodestruction Rate as a Metric to Evaluate Sonoporation Efficiency

Tamošiūnas

Jurkonis

Mir

et al. 2012

Journal of Ultrasound in Medicine

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Section: Discussionmentioning

confidence: 99%

Microbubble Sonodestruction Rate as a Metric to Evaluate Sonoporation Efficiency

Tamošiūnas

Jurkonis

Mir

et al. 2012

Journal of Ultrasound in Medicine

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“…Once cavitation is initiated, the target CI = 8 in point C could easily jump to a higher cavitation state (point D) due to the metastable behaviour of the phenomenon. Following the upper branch by decreasing the applied acoustic intensity would result to come back to the target (point E), before repeating this process in the range of acoustic intensities lying between points A and C. This real-time modulation technique has been the basics of first feedback loop process to control cavitation activity in continuous [17] and pulsed [18] ultrasound sonication. Of interest is the fact that this hysteretic curve appears as the envelope of overall cavitation activity as a function of acoustic intensity used to demonstrate the variability of the process (see Fig.…”

Section: Numerical Resultsmentioning

confidence: 99%

“…Of interest is the fact that this hysteretic curve appears as the envelope of overall cavitation activity as a function of acoustic intensity used to demonstrate the variability of the process (see Fig. 4 of [17] for instance). As a consequence, this characteristic curve can be used as a calibration measurement in order to define the range of acoustic intensities in which a control process could be performed.…”

Section: Numerical Resultsmentioning

confidence: 99%

Hysteresis of inertial cavitation activity induced by fluctuating bubble size distribution

Seya

Desjouy

Béra

et al. 2015

Ultrasonics Sonochemistry

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Amongst the variety of complex phenomena encountered in nonlinear physics, a hysteretic effect can be expected on ultrasound cavitation due to the intrinsic nonlinearity of bubble dynamics. When applying successive ultrasound shots for increasing and decreasing acoustic intensities, a hysteretic behaviour is experimentally observed on inertial cavitation activity, with a loop area sensitive to the inertial cavitation threshold. To get a better insight of the phenomena underlying this hysteretic effect, the evolution of the bubble size distribution is studied numerically by implementing rectified diffusion, fragmentation process, rising and dissolution of bubbles from an initial bubble size distribution. When applying increasing and decreasing acoustic intensities, the numerical distribution exhibits asymmetry in bubble number and distribution. The resulting inertial cavitation activity is assessed through the numerical broadband noise of the emitted acoustic radiation of the bubble cloud dynamics. This approach allows obtaining qualitatively the observed hysteretic effect and its interest in terms of control is discussed.

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“…When the injected microbubbles are exposed to an acoustic field, they not only reflect the sound, but also generate their own unique acoustic emissions, such as subharmonics (f0/m, where f0 is the fundamental frequency and m is an integer value), harmonics, ultra-harmonics (nf0/m, where n is also an integer value), and broadband signals. To improve the performance and safety of the therapeutic procedure, feedback control technologies based on detecting microbubble emissions have been developed [1][2][3][4][5]. The detection of subharmonics [6], harmonics [1] or ultra-harmonics [7] from microbubbles has been used to adjust the sonication pressure to produce safer and more effective treatments.…”

Section: Introductionmentioning

confidence: 99%

A PZT–PVDF Stacked Transducer for Short-Pulse Ultrasound Therapy and Monitoring

Jiang

Dickinson

Hall

et al. 2021

IEEE Trans. Ultrason., Ferroelect., Freq. Contr.

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Therapeutic ultrasound technologies using microbubbles require a feedback control system to perform the treatment in a safe and effective manner. Current feedback control technologies utilize the microbubble's acoustic emissions to adjust the treatment acoustic parameters. Typical systems use two separated transducers: one for transmission and the other for reception. However, separating the transmitter and receiver leads to foci misalignment. This limitation could be resolved by arranging the transmitter and receiver in a stacked configuration. Taking advantage of an increasing number of short-pulse-based therapeutic methods, we have constructed a PZT-PVDF stacked transducer design that allows the transmission and reception of short-pulse ultrasound from the same location. Our design had a piston transmitter composed of a PZT disc (1 MHz, 12.7 mm in diameter), a backing layer, and two matching layers. A layer of Polyvinylidene fluoride (PVDF) (28 μm in thickness, 12.7 mm in diameter) was placed at the front surface of the transmitter for reception. Transmission and reception from the same location was demonstrated in pulse-echo experiments where PZT transmitted a pulse and both PZT and PVDF received the echo. The echo signal received by the PVDF was 0.43 μs shorter than the signal received by the PZT. Reception of broadband acoustic emissions using the PVDF was also demonstrated in experiments where microbubbles were exposed to ultrasound pulses. Thus, we have shown that our PZT-PVDF stack design has unique transmission and reception features that could be incorporated into a multi-element array design that improves focal superimposing, transmission efficiency, and reception sensitivity.

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Feedback loop process to control acoustic cavitation

Cited by 30 publications

References 24 publications

Microbubble Sonodestruction Rate as a Metric to Evaluate Sonoporation Efficiency

Microbubble Sonodestruction Rate as a Metric to Evaluate Sonoporation Efficiency

Hysteresis of inertial cavitation activity induced by fluctuating bubble size distribution

A PZT–PVDF Stacked Transducer for Short-Pulse Ultrasound Therapy and Monitoring

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