Feedback Regulation of Pancreatic Exocrine Secretion in Minipigs

Abstract

A negative feedback regulation of pancreatic exocrine secretion is present in starved minipigs. Duodenal acidity and plasma levels of secretin semm to be of importance, whereas duodenal enzyme activity and the level of CCK in plasma probably are not. A postprandial negative feedback regulation through duodenal enzymatic activity and release of CCK into blood could not be shown.

Ileal exposure to pig pancreatic juice and bile inhibit exocrine pancreatic secretion in pigs

“…In contrast to the study of Houe et al (1997), presented results confirm the existence of CCK mediated feedback inhibition mechanism exerted by duodenal pancreatic juice under prandial conditions. The CCK blood levels decreased parallel to lowered trypsin/protein output.…”

“…The duodenal feedback regulation of pancreatic secretion in fed state by luminal proteases was observed in some (Owyang et al, 1986;Pierzynowski et al, 1999) but not in all studies (Houe et al, 1997). Houe et al (1997) failed to show a postprandial negative feedback regulation through duodenal enzymatic activity and release of CCK into peripheral blood. Moreover, data is still lacking concerning effects on pancreatic exocrine secretion of pancreatic juice or enzymes, bile or bile salts when they are presented in the ileum.…”

Attempt to establish a chronic model to study the influence of bile and pancreatic juice diversion on pancreas feedback regulation in conscious pigs

“…In pigs, there is a controversy concerning the existence of feedback regulation. Bile has been known to affect feedback regulation in animal species other than pigs and in humans, but the mechanism remains unclear (Green and Nasset, 1980;Houe et al, 1997). Some researchers suggested that bile acids may stabilize luminal protease activity resulting in inhibition of CCK release, and others are of the opinion that the inhibition of plasma CCK is achieved due to enhanced somatostatin release by the bile (Koop et al, 1996).…”