Feedback-related potentials and oscillations during trial and error learning in Parkinson’s disease

Viñales, L.; Procyk, Emmanuel; Quilodran, René

doi:10.1101/2021.04.05.438433

Cited by 3 publications

(3 citation statements)

References 72 publications

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“…Analysis of beta band showed error-related increased in PD off, within group and also when contrasted with HCs. Beta rhythm has been associated to sensorimotor control (Jurkiewicz et al, 2006; Pfurtscheller et al, 2005; Torrecillos et al, 2015), learning tasks (Viñales et al, 2021) and long-distance communication between visual and sensorimotor areas (Engel & Fries, 2010). Local field recordings from the subthalamic nucleus identified excessive beta activity in PD associated to with pathophysiological motor symptoms (Oswal et al, 2013), that was restored by the dopaminergic treatment (Doyle et al, 2005).…”

Section: Discussionmentioning

confidence: 99%

“…Analysis of beta band showed error-related increased in PD off, within group and also when contrasted with HCs. Beta rhythm has been associated to sensorimotor control (Jurkiewicz et al, 2006;Pfurtscheller et al, 2005;Torrecillos et al, 2015), learning tasks (Viñales et al, 2021) and long-distance communication between visual and sensorimotor areas beta activity in PD associated to with pathophysiological motor symptoms (Oswal et al, 2013), that was restored by the dopaminergic treatment (Doyle et al, 2005). Studies indicate that beta rebound was stronger after incorrect rather than correct actions, suggesting a potential role of beta in the evaluation of action significance and active response inhibition (Koelewijn et al, 2008).…”

Section: Delta Alpha and Beta Frequencies In Response To Errorsmentioning

confidence: 99%

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Selective influence of dopamine on electrocortical signatures of error monitoring: a combined EEG and immersive virtual reality study in Parkinson’s disease

Pezzetta

Ozkan

Era

et al. 2022

Preprint

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The saliency of detecting errors in one's own and other's actions is likely linked to the discrepancy between intended or expected and produced or observed output. Salient events seem related to dopamine, the balance of which is profoundly altered in Parkinson's disease (PD). EEG studies in healthy participants indicate that the occurrence of errors in observed actions triggers a variety of electrocortical indices (like mid-frontal theta activity and the Error Positivity, oPe), that seem to map different aspects of error detection and performance monitoring. Whether these indices are differently modulated by dopamine in the same individual has never been investigated. To explore this issue, we recorded EEG markers of error detection by asking healthy controls (HCs) and PD patients to observe ecological reach-to-grasp a glass actions performed by a virtual arm seen in first person perspective. PD patients were tested under their dopaminergic medication ('on-condition'), and after dopaminergic withdrawal ('off-condition'). HCs showed a clear oPe and an increase of theta power during the observation of erroneous vs. correct actions. In PD patients, oPe responses were always preserved. Crucially, however, an error-related increase of theta power was found in 'on' but not in 'off' state PD patients. Thus, different EEG error signatures may index the activity of independent systems and error-related theta power is selectively modulated by dopamine depletion. Our findings may pave the way to the discovery of dopamine-related biomarkers of higher-order motor cognition dysfunctions that may have crucial theoretical and applied implications.

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Section: Discussionmentioning

confidence: 99%

“…Analysis of beta band showed error-related increased in PD off, within group and also when contrasted with HCs. Beta rhythm has been associated to sensorimotor control (Jurkiewicz et al, 2006;Pfurtscheller et al, 2005;Torrecillos et al, 2015), learning tasks (Viñales et al, 2021) and long-distance communication between visual and sensorimotor areas beta activity in PD associated to with pathophysiological motor symptoms (Oswal et al, 2013), that was restored by the dopaminergic treatment (Doyle et al, 2005). Studies indicate that beta rebound was stronger after incorrect rather than correct actions, suggesting a potential role of beta in the evaluation of action significance and active response inhibition (Koelewijn et al, 2008).…”

Section: Delta Alpha and Beta Frequencies In Response To Errorsmentioning

confidence: 99%

Selective influence of dopamine on electrocortical signatures of error monitoring: a combined EEG and immersive virtual reality study in Parkinson’s disease

Pezzetta

Ozkan

Era

et al. 2022

Preprint

View full text Add to dashboard Cite

show abstract

“…Analysis of beta-band showed error-related increased in PD off, within-group and also when contrasted with HCs. Beta rhythm has been associated to sensorimotor control [86][87][88] , learning tasks 89 , and long-distance communication between visual and sensorimotor areas 90 . Previous studies on epileptic patients showed that alpha and beta frequency modulation was present while executing and observing reach and grasp actions 91 .…”

Section: Discussionmentioning

confidence: 99%

Combined EEG and immersive virtual reality unveil dopaminergic modulation of error monitoring in Parkinson’s Disease

Pezzetta

Ozkan

Era

et al. 2023

npj Parkinsons Dis.

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Detecting errors in your own and others’ actions is associated with discrepancies between intended and expected outcomes. The processing of salient events is associated with dopamine release, the balance of which is altered in Parkinson’s disease (PD). Errors in observed actions trigger various electrocortical indices (e.g. mid-frontal theta, error-related delta, and error positivity [oPe]). However, the impact of dopamine depletion to observed errors in the same individual remains unclear. Healthy controls (HCs) and PD patients observed ecological reach-to-grasp-a-glass actions performed by a virtual arm from a first-person perspective. PD patients were tested under their dopaminergic medication (on-condition) and after dopaminergic withdrawal (off-condition). Analyses of oPe, delta, and theta-power increases indicate that while the formers were elicited after incorrect vs. correct actions in all groups, the latter were observed in on-condition but altered in off-condition PD. Therefore, different EEG error signatures may index the activity of distinct mechanisms, and error-related theta power is selectively modulated by dopamine depletion. Our findings may facilitate discovering dopamine-related biomarkers for error-monitoring dysfunctions that may have crucial theoretical and clinical implications.

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Theta-Gamma Decoupling – A neurophysiological marker of impaired reward processing in Parkinson’s disease

Sharma,

Thirugnanasambandam

2024

Brain Research

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Feedback-related potentials and oscillations during trial and error learning in Parkinson’s disease

Cited by 3 publications

References 72 publications

Selective influence of dopamine on electrocortical signatures of error monitoring: a combined EEG and immersive virtual reality study in Parkinson’s disease

Selective influence of dopamine on electrocortical signatures of error monitoring: a combined EEG and immersive virtual reality study in Parkinson’s disease

Combined EEG and immersive virtual reality unveil dopaminergic modulation of error monitoring in Parkinson’s Disease

Theta-Gamma Decoupling – A neurophysiological marker of impaired reward processing in Parkinson’s disease

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