BackgroundPercutaneous endoscopic gastrostomy (PEG) tube placement is the most common enteral access for long‐term feeding. The aim of our study is to assess the feasibility and safety of immediate PEG tube use after initial placement.MethodsWe conducted a single center retrospective cohort study between August 2006 and August 2016. Prior to August 2011 tube feeding were delayed for 4 or more hours after initial PEG placement, compared with immediate use (< 1 hour) after August 2011. Primary outcomes were complication rates within 30 days of placement. Secondary outcomes were impact of morbidity, mortality, length of stay and need for repeat PEG placement.ResultsOur study included 1296 patients during the 10‐year period, of which 704 underwent delayed use versus 592 underwent immediate use (744 inpatient and 552 outpatient). There were no significant differences between the delayed use and immediate use PEG with regards to complications (3.4% vs 4.4%; p=.76). Subgroup analysis also reflected no significant differences in complications between inpatient and outpatient groups. For inpatients, there were no substantial differences in inpatient mortality (3.9% vs 3.3%; p=.70), mortality within 30 days of discharge (13.8% vs 13.1%; p=.15), readmissions (38.2% vs 34.3%; p=.23), repeat PEG placement (0.7% vs 1.5%; p=.46), and length of stay (13.3 days vs 13.9 days; p=.99).ConclusionPatients who received immediate enteral nutrition after PEG tube placement did not have any increased complications, morbidity, or mortality; and is just as safe when compared to patients who received delayed feeding.This article is protected by copyright. All rights reserved.